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19.11.2021 | Ideas and Innovations

Pectus excavatum camouflage: a new technique using a tissue engineered scaffold

verfasst von: Matthew E. Cheng, Jan Janzekovic, Harrison J. Theile, Caitlin Rutherford-Heard, Marie-Luise Wille, Chris Cole, Thomas B. Lloyd, Richard J. W. Theile, Michael Wagels, Dietmar W. Hutmacher

Erschienen in: European Journal of Plastic Surgery | Ausgabe 1/2022

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Abstract

Pectus excavatum is the most common congenital chest wall deformity. Customised silicone implants have been used to camouflage this deformity with good short-term outcomes. In the long term, permanent implants have a significant risk of capsular contracture, migration and extrusion. Scaffold-guided tissue engineering provides an alternative autologous solution which avoids issues associated with permanent implants. We implanted a 3D-printed, custom-made, biodegradable and highly porous scaffold filled with autologous fat graft. We were able to sustain autologous fat in the construct. There was an excellent aesthetic outcome and the highly porous polycaprolactone implant was well tolerated by the patient. This case illustrates the first-in-human trial of soft tissue engineering to camouflage a pectus excavatum defect not reconstructable by conventional techniques.

Level of evidence: Level V, therapeutic study.

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Titel: Pectus excavatum camouflage: a new technique using a tissue engineered scaffold
verfasst von: Matthew E. Cheng
Jan Janzekovic
Harrison J. Theile
Caitlin Rutherford-Heard
Marie-Luise Wille
Chris Cole
Thomas B. Lloyd
Richard J. W. Theile
Michael Wagels
Dietmar W. Hutmacher
Publikationsdatum: 19.11.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Plastic Surgery / Ausgabe 1/2022
Print ISSN: 0930-343X
Elektronische ISSN: 1435-0130
DOI: https://doi.org/10.1007/s00238-021-01902-5

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