Skip to main content
Erschienen in: International Ophthalmology 5/2018

29.08.2017 | Review

Pediatric keratoconus: a review of the literature

verfasst von: Sabrina Mukhtar, Balamurali K. Ambati

Erschienen in: International Ophthalmology | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To describe the epidemiology and prevalence, rates of progression, difference between adult and pediatric populations, and therapeutic approaches to pediatric keratoconus from documented literature.

Methods

A literature search was done on PubMed using key words including pediatric keratoconus, children with keratoconus, adult keratoconus, penetrating keratoplasty, corneal cross-linking and intracorneal ring segments. The literature was reviewed and reported to explore the key epidemiological differences between the pediatric and adult population with regards to presentation and treatment options.

Results

Pediatric keratoconus is more aggressive than adult keratoconus, which has been explained by structural differences in the cornea between both populations. High rates of progression were documented in pediatric populations. While corneal collagen cross-linking, intracorneal ring segments and penetrating keratoplasties have been used as therapies in the pediatric population, the literature overwhelmingly shows higher rates of failure and progression despite these measures as compared to adults.

Conclusion

Pediatric keratoconus is more aggressive than adult keratoconus, and current therapies used in adults may not be sufficient for the pediatric population.
Literatur
1.
Zurück zum Zitat Kankariya VP, Kymionis GD, Diaknois VF et al (2013) Management of pediatric keratoconus—evolving role of corneal collagen cross-linking: an update. Ind J Ophthalmol 61(8):435–440CrossRef Kankariya VP, Kymionis GD, Diaknois VF et al (2013) Management of pediatric keratoconus—evolving role of corneal collagen cross-linking: an update. Ind J Ophthalmol 61(8):435–440CrossRef
2.
Zurück zum Zitat Tuf SJ, Moodaley LC, Gregory WM et al (1994) Prognostic factors for the progression of keratoconus. Ophthalmology 101:439–447CrossRef Tuf SJ, Moodaley LC, Gregory WM et al (1994) Prognostic factors for the progression of keratoconus. Ophthalmology 101:439–447CrossRef
4.
Zurück zum Zitat El Rami H, Chelala E, Dirani A et al (2015) An update on the safety and efficacy of corneal collagen cross-linking in pediatric keratoconus. BioMed Res Int El Rami H, Chelala E, Dirani A et al (2015) An update on the safety and efficacy of corneal collagen cross-linking in pediatric keratoconus. BioMed Res Int
5.
Zurück zum Zitat Raiskup-Wolf F, Hoyer A, Spoerl E et al (2008) Collagen crosslinking with riboflavin and ultraviolet—a light in keratoconus: long term results. J Cataract Refract Surg 34(5):796–801CrossRefPubMed Raiskup-Wolf F, Hoyer A, Spoerl E et al (2008) Collagen crosslinking with riboflavin and ultraviolet—a light in keratoconus: long term results. J Cataract Refract Surg 34(5):796–801CrossRefPubMed
6.
Zurück zum Zitat Sabti S, Tappeiner C, Frueh BE (2015) Corneal Cross-linking in a 4-year old child with keratoconus and down syndrome. Cornea 34(9):1157–1160PubMedCrossRef Sabti S, Tappeiner C, Frueh BE (2015) Corneal Cross-linking in a 4-year old child with keratoconus and down syndrome. Cornea 34(9):1157–1160PubMedCrossRef
7.
Zurück zum Zitat Jonas JB, Nangia V, Matin A et al (2009) Prevalence and associations of keratoconus in rural Maharashtra in central India: the Central India Eye and Medical Study. Am J Ophthalmol 148(5):760–765PubMedCrossRef Jonas JB, Nangia V, Matin A et al (2009) Prevalence and associations of keratoconus in rural Maharashtra in central India: the Central India Eye and Medical Study. Am J Ophthalmol 148(5):760–765PubMedCrossRef
8.
Zurück zum Zitat Millodot M, Shneor E, Albou S et al (2011) Prevalence and associated factors of keratoconus in Jerusalem: a cross-sectional study. Ophthalmic Epidemiol 18(2):91–97PubMedCrossRef Millodot M, Shneor E, Albou S et al (2011) Prevalence and associated factors of keratoconus in Jerusalem: a cross-sectional study. Ophthalmic Epidemiol 18(2):91–97PubMedCrossRef
9.
Zurück zum Zitat Wakend N, Fayad AM, Fadlallah A et al (2012) Keratoconus screening in Lebanese students’ population. J Fr Ophthalmol 35(1):23–29CrossRef Wakend N, Fayad AM, Fadlallah A et al (2012) Keratoconus screening in Lebanese students’ population. J Fr Ophthalmol 35(1):23–29CrossRef
10.
Zurück zum Zitat Xu L, Wang YX, Guo Y et al (2012) Prevalence and associations of steep cornea/keratoconus in greater Beijing. The Beijing Eye Study. PLoS ONE 7(7):e39313PubMedPubMedCentralCrossRef Xu L, Wang YX, Guo Y et al (2012) Prevalence and associations of steep cornea/keratoconus in greater Beijing. The Beijing Eye Study. PLoS ONE 7(7):e39313PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Hashemi H, Khabazkhoob M, Fotouhi A (2013) Topographic keratoconus is not rare in an Iranian population: the Tehran eye study. Ophthalmic Epidemiol 20(6):385–391PubMedCrossRef Hashemi H, Khabazkhoob M, Fotouhi A (2013) Topographic keratoconus is not rare in an Iranian population: the Tehran eye study. Ophthalmic Epidemiol 20(6):385–391PubMedCrossRef
12.
Zurück zum Zitat Hashemi H, Khabazkhoob M, Yazdani N et al (2014) The prevalence of keratoconus in a young population in Mashad. Iran Ophthalmic Physiol Opt 34(5):519–527PubMedCrossRef Hashemi H, Khabazkhoob M, Yazdani N et al (2014) The prevalence of keratoconus in a young population in Mashad. Iran Ophthalmic Physiol Opt 34(5):519–527PubMedCrossRef
13.
Zurück zum Zitat Shneor E, Millodot M, Gordon-Shaag A et al (2014) Prevalence of keratoconus among young Arab students in Israel. Int J Kerato Ectatic Corneal Dis 3(1):9–14CrossRef Shneor E, Millodot M, Gordon-Shaag A et al (2014) Prevalence of keratoconus among young Arab students in Israel. Int J Kerato Ectatic Corneal Dis 3(1):9–14CrossRef
14.
Zurück zum Zitat Hashemi H, Beiranvand A, Khabazkhoob M et al (2013) Prevalence of keratoconus in a population-based study in Shahroud. Cornea 32(11):1441–1445PubMedCrossRef Hashemi H, Beiranvand A, Khabazkhoob M et al (2013) Prevalence of keratoconus in a population-based study in Shahroud. Cornea 32(11):1441–1445PubMedCrossRef
15.
Zurück zum Zitat Pearson AR, Soneji B, Sarvananthan N et al (2000) Does ethnic origin influence the incidence or severity of keratoconus? Eye 14:625–628PubMedCrossRef Pearson AR, Soneji B, Sarvananthan N et al (2000) Does ethnic origin influence the incidence or severity of keratoconus? Eye 14:625–628PubMedCrossRef
16.
Zurück zum Zitat Georgious T, Funnell CL, Cassels-Brown A et al (2004) Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients. Eye 18(4):383–397 Georgious T, Funnell CL, Cassels-Brown A et al (2004) Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients. Eye 18(4):383–397
17.
Zurück zum Zitat Cozma I, Atherley C, James NJ et al (2005) Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asian and white patients. Eye 19(8):924–926PubMedCrossRef Cozma I, Atherley C, James NJ et al (2005) Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asian and white patients. Eye 19(8):924–926PubMedCrossRef
18.
Zurück zum Zitat Pan CW, Cheng CY, Sanayagam C et al (2014) Ethnic variation in central corneal refractive power and steep cornea in Asians. Ophthalmic Epidemiol 21(2):99–105PubMedCrossRef Pan CW, Cheng CY, Sanayagam C et al (2014) Ethnic variation in central corneal refractive power and steep cornea in Asians. Ophthalmic Epidemiol 21(2):99–105PubMedCrossRef
19.
Zurück zum Zitat Gordon Shaag A, Millodot M, Shneor E et al (2015) The genetic and environmental factors for keratoconus. BioMed Res Int 19 Gordon Shaag A, Millodot M, Shneor E et al (2015) The genetic and environmental factors for keratoconus. BioMed Res Int 19
20.
Zurück zum Zitat Li X, Rabinowitz YS, Rasheed K et al (2004) Longitudinal study of the normal eyes in unilateral keratoconus patients. Ophthalmology 111(3):440–446PubMedCrossRef Li X, Rabinowitz YS, Rasheed K et al (2004) Longitudinal study of the normal eyes in unilateral keratoconus patients. Ophthalmology 111(3):440–446PubMedCrossRef
21.
Zurück zum Zitat Lema I, Duran JA, Ruiz C, Diez-Feijoo E, Acera A, Merayo J (2008) Inflammatory response to contact lenses in patients iwth keratoconus compared with myopic subjects. Cornea 27:758–763PubMedCrossRef Lema I, Duran JA, Ruiz C, Diez-Feijoo E, Acera A, Merayo J (2008) Inflammatory response to contact lenses in patients iwth keratoconus compared with myopic subjects. Cornea 27:758–763PubMedCrossRef
22.
Zurück zum Zitat Lema I, Sobrino T, Duran JA et al (2009) Subclinical keratoconus and inflammatory molecules from tears. Br J Ophthalmol 93(6):820–824PubMedCrossRef Lema I, Sobrino T, Duran JA et al (2009) Subclinical keratoconus and inflammatory molecules from tears. Br J Ophthalmol 93(6):820–824PubMedCrossRef
23.
Zurück zum Zitat Mackiewicz ZMM, Stenman M, Konttinen L, Tervo T, Konttinen YT (2006) Collagenolytic proteinases in keratoconus. Cornea 25:603–610PubMedCrossRef Mackiewicz ZMM, Stenman M, Konttinen L, Tervo T, Konttinen YT (2006) Collagenolytic proteinases in keratoconus. Cornea 25:603–610PubMedCrossRef
24.
Zurück zum Zitat Pouliquen Y, Bureau J, Mirshahi M, Mirshahi SS, Assouline M, Lorens G (1996) Keratoconus and inflammatory processes. Bull Soc Belge Ophthalmol 262:25–28 Pouliquen Y, Bureau J, Mirshahi M, Mirshahi SS, Assouline M, Lorens G (1996) Keratoconus and inflammatory processes. Bull Soc Belge Ophthalmol 262:25–28
25.
Zurück zum Zitat Bauman KA, Wettlaufer SH, Okunishi K et al (2010) The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice. J Clin Invest 120:1950–1960PubMedPubMedCentralCrossRef Bauman KA, Wettlaufer SH, Okunishi K et al (2010) The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice. J Clin Invest 120:1950–1960PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Balasubramanian SA, Wasinger VC, Pye DC, Willcox MD (2013) Preliminary identification of differentially expressed tear proteins in keratoconus. Mol Vis 19:2124–2134PubMedPubMedCentral Balasubramanian SA, Wasinger VC, Pye DC, Willcox MD (2013) Preliminary identification of differentially expressed tear proteins in keratoconus. Mol Vis 19:2124–2134PubMedPubMedCentral
27.
Zurück zum Zitat Acera A, Vecino E, Rodriquez-Agirretxe I et al (2011) Changes in tear protein profile in keratoconus disease. Eye (Lond) 25:1225–1233CrossRef Acera A, Vecino E, Rodriquez-Agirretxe I et al (2011) Changes in tear protein profile in keratoconus disease. Eye (Lond) 25:1225–1233CrossRef
28.
Zurück zum Zitat Cheung IM, McGee CN, Sherwin T (2013) A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species-associated processes. Clin Exp Ophthalmol 96:188–196 Cheung IM, McGee CN, Sherwin T (2013) A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species-associated processes. Clin Exp Ophthalmol 96:188–196
30.
Zurück zum Zitat Wojcik KA, Blasiak J, Szaflik J, Szaflik JP (2014) Role of biochemical factors in the pathogenesis of keratoconus. Acta Biochem Polonica 61:55–62 Wojcik KA, Blasiak J, Szaflik J, Szaflik JP (2014) Role of biochemical factors in the pathogenesis of keratoconus. Acta Biochem Polonica 61:55–62
31.
Zurück zum Zitat Davidson AE, Hayes S, Hardcastle AJ et al (2014) The pathogenesis of keratoconus. Eye 28(2):189–195PubMedCrossRef Davidson AE, Hayes S, Hardcastle AJ et al (2014) The pathogenesis of keratoconus. Eye 28(2):189–195PubMedCrossRef
32.
Zurück zum Zitat Leoni-Mesplie S, Mortemousque B, Mesplie N et al (2012) Epidemiologcal aspects of keratoconus in children. Fr J Ophthalmol 35(10):776–785CrossRef Leoni-Mesplie S, Mortemousque B, Mesplie N et al (2012) Epidemiologcal aspects of keratoconus in children. Fr J Ophthalmol 35(10):776–785CrossRef
33.
Zurück zum Zitat Balasubramanian SAPD, Wilcox MD (2013) Effects of eye rubbing on the levels of protease, protease activity and cytokines in tears: relevance in keratoconus. Clin Exp Ophthalmol 96:214–218 Balasubramanian SAPD, Wilcox MD (2013) Effects of eye rubbing on the levels of protease, protease activity and cytokines in tears: relevance in keratoconus. Clin Exp Ophthalmol 96:214–218
34.
Zurück zum Zitat Gonzales V, McDonnell PJ (1992) Computer-assisted corneal topography in parents of patients with keratoconus. Arch Ophthalmol 110(10):1412–1414CrossRef Gonzales V, McDonnell PJ (1992) Computer-assisted corneal topography in parents of patients with keratoconus. Arch Ophthalmol 110(10):1412–1414CrossRef
35.
Zurück zum Zitat Rabinowitz YS, Garbus J, McDonnell PJ (1990) Computer-assisted corneal topography in family members of patients with keratoconus. Arch Ophthalmol 108(3):365–371PubMedCrossRef Rabinowitz YS, Garbus J, McDonnell PJ (1990) Computer-assisted corneal topography in family members of patients with keratoconus. Arch Ophthalmol 108(3):365–371PubMedCrossRef
36.
Zurück zum Zitat Caputo R, Versaci F, Pucci N, de Libero C et al (2016) Very low prevalence of keratoconus in a large series of vernal keratoconjunctivitis patients. Am J Ophthalmol 172:64–71PubMedCrossRef Caputo R, Versaci F, Pucci N, de Libero C et al (2016) Very low prevalence of keratoconus in a large series of vernal keratoconjunctivitis patients. Am J Ophthalmol 172:64–71PubMedCrossRef
37.
Zurück zum Zitat Adachi W, Mitsuishi Y, Terai K et al (2002) The association of HLA with young-onset keratoconus in Japan. Am J Ophthalmol 133:557–559PubMedCrossRef Adachi W, Mitsuishi Y, Terai K et al (2002) The association of HLA with young-onset keratoconus in Japan. Am J Ophthalmol 133:557–559PubMedCrossRef
38.
Zurück zum Zitat Kamiya K, Shimizu K, Ohmoto F (2009) Effect of aging on corneal biochemical parameters using the ocular response analyzer. J Refract Surg 25:888–893PubMedCrossRef Kamiya K, Shimizu K, Ohmoto F (2009) Effect of aging on corneal biochemical parameters using the ocular response analyzer. J Refract Surg 25:888–893PubMedCrossRef
39.
Zurück zum Zitat Rehany U, Rumelt S (1995) Corneal hydrops associated with vernal conjunctivitis as a presenting sign of keratoconus in children. Ophthalmology 102(12):2046–2049PubMedCrossRef Rehany U, Rumelt S (1995) Corneal hydrops associated with vernal conjunctivitis as a presenting sign of keratoconus in children. Ophthalmology 102(12):2046–2049PubMedCrossRef
40.
Zurück zum Zitat Reeves SW, Stinnett S, Adelman RA et al (2005) Risk factors for progression to penetrating keratoplasty in patients with keratoconus. Am J Ophthalmol 140(4):607-e601–607-e606CrossRef Reeves SW, Stinnett S, Adelman RA et al (2005) Risk factors for progression to penetrating keratoplasty in patients with keratoconus. Am J Ophthalmol 140(4):607-e601–607-e606CrossRef
41.
Zurück zum Zitat Kotecha A, Elsheikh A, Robertsr C et al (2006) Corneal thickness and age-related biomechanical properties of the cornea measured with the ocular response analyzer. Invest Ophthalmol Vis Sci 47:5337–5347PubMedCrossRef Kotecha A, Elsheikh A, Robertsr C et al (2006) Corneal thickness and age-related biomechanical properties of the cornea measured with the ocular response analyzer. Invest Ophthalmol Vis Sci 47:5337–5347PubMedCrossRef
42.
Zurück zum Zitat Ertan A, Muftuoglu O (2008) Keratoconus clinical findings according to different age and gender groups. Cornea 27:1109–1113PubMedCrossRef Ertan A, Muftuoglu O (2008) Keratoconus clinical findings according to different age and gender groups. Cornea 27:1109–1113PubMedCrossRef
43.
Zurück zum Zitat Gordon MO, Steger-May KLS-F et al (2006) Baseline factors predictive of incident penetrating keratoplasty in keratoconus. Am J Ophthalmol 142(6):923–930PubMedCrossRef Gordon MO, Steger-May KLS-F et al (2006) Baseline factors predictive of incident penetrating keratoplasty in keratoconus. Am J Ophthalmol 142(6):923–930PubMedCrossRef
44.
Zurück zum Zitat Amsler M (1961) Quelques donnees du problem. Bull Soc Belge Ophthalmol 129:331–334 Amsler M (1961) Quelques donnees du problem. Bull Soc Belge Ophthalmol 129:331–334
45.
Zurück zum Zitat Chatzis N, Hafezi F (2012) Progression of keratoconus and efficiency of pediatric [corrected] corneal collagen cross-linking in children and adolescents. J Refract Surg 28(11):753–758PubMedCrossRef Chatzis N, Hafezi F (2012) Progression of keratoconus and efficiency of pediatric [corrected] corneal collagen cross-linking in children and adolescents. J Refract Surg 28(11):753–758PubMedCrossRef
46.
Zurück zum Zitat McMahon TT, Edrington TB, Szczotka-Flynn L et al (2006) Longitudinal changes in corneal curvature in keratoconus. Cornea 25:296–305PubMedCrossRef McMahon TT, Edrington TB, Szczotka-Flynn L et al (2006) Longitudinal changes in corneal curvature in keratoconus. Cornea 25:296–305PubMedCrossRef
47.
Zurück zum Zitat Dana MR, Putz JL, Viana MA et al (1992) Contact lens failure in keratoconus management. Ophthalmology 99(8):1187–1192PubMedCrossRef Dana MR, Putz JL, Viana MA et al (1992) Contact lens failure in keratoconus management. Ophthalmology 99(8):1187–1192PubMedCrossRef
48.
Zurück zum Zitat Pouliquen Y, Forman MR, Giraud JP (1981) Vitnesse d’evolution du keratocone: etude des relations entre l’age de decourverte et l’age auguel il est opra. Fr J Ophthalmol 4:219–221 Pouliquen Y, Forman MR, Giraud JP (1981) Vitnesse d’evolution du keratocone: etude des relations entre l’age de decourverte et l’age auguel il est opra. Fr J Ophthalmol 4:219–221
49.
Zurück zum Zitat Lass JH, Lembach RG, Park SB et al (1990) Clinical management of keratoconus: a multicenter analysis. Ophthalmology 90:433–445CrossRef Lass JH, Lembach RG, Park SB et al (1990) Clinical management of keratoconus: a multicenter analysis. Ophthalmology 90:433–445CrossRef
50.
Zurück zum Zitat Kennedy RHBW, Dyer JA (1986) A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol 101:267–273PubMedCrossRef Kennedy RHBW, Dyer JA (1986) A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol 101:267–273PubMedCrossRef
51.
Zurück zum Zitat Woodward EG, Moodely LC, O’Hagan A (1990) Predictors for likelihood of corneal transplantation in keratoconus. Eye 4:493–496PubMedCrossRef Woodward EG, Moodely LC, O’Hagan A (1990) Predictors for likelihood of corneal transplantation in keratoconus. Eye 4:493–496PubMedCrossRef
52.
Zurück zum Zitat Hamilton A, Wong S, Carley F et al (2015) Tomographic indices as possible risk factors for progression in pediatric keratoconus. J AAPOS 20:523–526CrossRef Hamilton A, Wong S, Carley F et al (2015) Tomographic indices as possible risk factors for progression in pediatric keratoconus. J AAPOS 20:523–526CrossRef
53.
Zurück zum Zitat Léoni-Mesplié SMB, Touboul D et al (2012) Scalability and severity of kertoconus in children. Am J Ophthalmol 154(1):56–62PubMedCrossRef Léoni-Mesplié SMB, Touboul D et al (2012) Scalability and severity of kertoconus in children. Am J Ophthalmol 154(1):56–62PubMedCrossRef
54.
Zurück zum Zitat Soeters N, van der Valk R, Tahzib NG (2014) Corneal cross-linking for treatment of progressive keratoconus in various age groups. J Refract Surg 30(7):454–460PubMedCrossRef Soeters N, van der Valk R, Tahzib NG (2014) Corneal cross-linking for treatment of progressive keratoconus in various age groups. J Refract Surg 30(7):454–460PubMedCrossRef
55.
Zurück zum Zitat Vinciguerra P, Albe E, Frueh BE et al (2012) Two year corneal cross-linking results in patients younger than 18 years with documented progressive keratoconus. Am J Ophthalmol 154(3):520–526PubMedCrossRef Vinciguerra P, Albe E, Frueh BE et al (2012) Two year corneal cross-linking results in patients younger than 18 years with documented progressive keratoconus. Am J Ophthalmol 154(3):520–526PubMedCrossRef
56.
Zurück zum Zitat Theuring A, Spoerl E, Pillunat LE et al (2015) Corneal collagen cross-linking with riboflavin and ultraviolet—A light in progresive keratoconus. Results after 10-year follow-up. Ophthalmologe 112(2):140–147PubMedCrossRef Theuring A, Spoerl E, Pillunat LE et al (2015) Corneal collagen cross-linking with riboflavin and ultraviolet—A light in progresive keratoconus. Results after 10-year follow-up. Ophthalmologe 112(2):140–147PubMedCrossRef
57.
Zurück zum Zitat Vinciguerra R, Romano M, Carnesasca F et al (2013) Corneal cross-linking as a treatment for keratoconus: four-year morphologic and clinical outcomes with respect to patient age. Ophthalmology 120:908–918PubMedCrossRef Vinciguerra R, Romano M, Carnesasca F et al (2013) Corneal cross-linking as a treatment for keratoconus: four-year morphologic and clinical outcomes with respect to patient age. Ophthalmology 120:908–918PubMedCrossRef
58.
59.
Zurück zum Zitat Ivarsen A, Hjortdal J (2013) Collagen cross-linking for advanced progressive keratoconus. Cornea 32(7):903–906PubMedCrossRef Ivarsen A, Hjortdal J (2013) Collagen cross-linking for advanced progressive keratoconus. Cornea 32(7):903–906PubMedCrossRef
60.
Zurück zum Zitat Low JR, Anshu A, Tan AC et al (2014) The outcomes of primary pediatric keratoplasty in Singapore. Am J Ophthalmol 158(3):496–502PubMedCrossRef Low JR, Anshu A, Tan AC et al (2014) The outcomes of primary pediatric keratoplasty in Singapore. Am J Ophthalmol 158(3):496–502PubMedCrossRef
61.
Zurück zum Zitat Waring GO, Laibson PR (1977) Keratoplasty in infants and children. Trans Sect Otolaryngol Am Acad Ophthalmol Otolaryngol 83(2):283–296 Waring GO, Laibson PR (1977) Keratoplasty in infants and children. Trans Sect Otolaryngol Am Acad Ophthalmol Otolaryngol 83(2):283–296
62.
Zurück zum Zitat Asuri MK, Garg P, Gokhle N et al (2000) Penetrating keratoplasty n children. Cornea 19(2):140–144CrossRef Asuri MK, Garg P, Gokhle N et al (2000) Penetrating keratoplasty n children. Cornea 19(2):140–144CrossRef
63.
Zurück zum Zitat Lowe MT, Keane MC, Coster DJ et al (2011) The outcome of corneal transplantation in infants, children, and adolescents. Ophthalmology 118(3):492–497PubMedCrossRef Lowe MT, Keane MC, Coster DJ et al (2011) The outcome of corneal transplantation in infants, children, and adolescents. Ophthalmology 118(3):492–497PubMedCrossRef
64.
Zurück zum Zitat Patel HY, Ormonde S, Brookes NH et al (1991–2003) The indications and outcome of pediatric corneal transplantation in New Zealand. Br J Ophthalmol 89(4):404–408 Patel HY, Ormonde S, Brookes NH et al (1991–2003) The indications and outcome of pediatric corneal transplantation in New Zealand. Br J Ophthalmol 89(4):404–408
65.
Zurück zum Zitat Cowden JW (1990) Penetrating keratoplasty in infants and children. Ophthalmology 97(3):324–328PubMedCrossRef Cowden JW (1990) Penetrating keratoplasty in infants and children. Ophthalmology 97(3):324–328PubMedCrossRef
66.
Zurück zum Zitat Arora R, Gupta D, Goyal JL et al (2012) Results of corneal collagen cross-linking in pediatric patients. J Refract Surg 28:759–762PubMedCrossRef Arora R, Gupta D, Goyal JL et al (2012) Results of corneal collagen cross-linking in pediatric patients. J Refract Surg 28:759–762PubMedCrossRef
67.
Zurück zum Zitat Wise S, Diaz C, Termote K et al (2016) Corneal cross-linking in pediatric patients with progressive keratoconus. Cornea 35(11):1441–1443PubMedCrossRef Wise S, Diaz C, Termote K et al (2016) Corneal cross-linking in pediatric patients with progressive keratoconus. Cornea 35(11):1441–1443PubMedCrossRef
68.
Zurück zum Zitat Bakshi E, Barkana Y, Goldich Y et al (2012) Corneal cross-linking for progressive keratoconus in children: our experience. Int J Kerato Ectatic Corneal Dis 1:53–56CrossRef Bakshi E, Barkana Y, Goldich Y et al (2012) Corneal cross-linking for progressive keratoconus in children: our experience. Int J Kerato Ectatic Corneal Dis 1:53–56CrossRef
69.
Zurück zum Zitat Toprak I, Yaylali V, Yildrim C (2016) Visual, topographic, and pacchymetric effects of pediatric corneal collagen cross-linking. J Pediatr Ophthalmol Strabismus 54:84–89PubMedCrossRef Toprak I, Yaylali V, Yildrim C (2016) Visual, topographic, and pacchymetric effects of pediatric corneal collagen cross-linking. J Pediatr Ophthalmol Strabismus 54:84–89PubMedCrossRef
70.
Zurück zum Zitat Sarac O, Caglayan M, Cakmak HB (2016) Factors influencing progresison of keratoconus 2 years after corneal collagen cross-linking in pediatric patients. Cornea (EPub ahead of print) Sarac O, Caglayan M, Cakmak HB (2016) Factors influencing progresison of keratoconus 2 years after corneal collagen cross-linking in pediatric patients. Cornea (EPub ahead of print)
71.
Zurück zum Zitat Caporossi A, Mazzotta C, Baiocchi S et al (2012) Riboflavin-UVA-induced corneal collagen cross-linking in pediatric patients. Cornea 31:227–231PubMedCrossRef Caporossi A, Mazzotta C, Baiocchi S et al (2012) Riboflavin-UVA-induced corneal collagen cross-linking in pediatric patients. Cornea 31:227–231PubMedCrossRef
72.
Zurück zum Zitat Zota PGMK, Diaknois VF et al (2012) Corneal collagen cross-linking for progressive keratoconus in pediatric patients: a feasibility study. J Refract Surg 28:793–799CrossRef Zota PGMK, Diaknois VF et al (2012) Corneal collagen cross-linking for progressive keratoconus in pediatric patients: a feasibility study. J Refract Surg 28:793–799CrossRef
73.
Zurück zum Zitat Padmanabhan P, Rachapalle R, Rajagopal R et al (2017) Corneal Collagen cross-linking for keratoconus in pediatric patients—long-term results. Cornea 36:138–142PubMedCrossRef Padmanabhan P, Rachapalle R, Rajagopal R et al (2017) Corneal Collagen cross-linking for keratoconus in pediatric patients—long-term results. Cornea 36:138–142PubMedCrossRef
74.
Zurück zum Zitat Ucakhan OO, Bayraktutar BN, Saglik A (2016) Pediatric corneal collagen cross-linking: long term follow up of visual, refractive and topographic outcomes. Cornea 35:162–168PubMedCrossRef Ucakhan OO, Bayraktutar BN, Saglik A (2016) Pediatric corneal collagen cross-linking: long term follow up of visual, refractive and topographic outcomes. Cornea 35:162–168PubMedCrossRef
75.
Zurück zum Zitat Godefrooji DA, Soeters N, Imhof SM, Wisse RP (2016) Corneal cross-linking for pediatric keratoconus: long term results. Cornea 35(7):954–958CrossRef Godefrooji DA, Soeters N, Imhof SM, Wisse RP (2016) Corneal cross-linking for pediatric keratoconus: long term results. Cornea 35(7):954–958CrossRef
76.
Zurück zum Zitat Kodavoor KS, Ariswala AZ, Ramamurthy D (2014) One year clinical study of efficacy of corneal cross-linking in Indian children with progressive keratoconus. Cornea 33(9):919–922CrossRef Kodavoor KS, Ariswala AZ, Ramamurthy D (2014) One year clinical study of efficacy of corneal cross-linking in Indian children with progressive keratoconus. Cornea 33(9):919–922CrossRef
77.
Zurück zum Zitat Mazzotta C, Balestrazze A, Baiocchi S et al (2007) Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in keratoconus: in vivo confocal microscopic evaluation. Clin Exp Ophthalmol 35:580–582PubMedCrossRef Mazzotta C, Balestrazze A, Baiocchi S et al (2007) Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in keratoconus: in vivo confocal microscopic evaluation. Clin Exp Ophthalmol 35:580–582PubMedCrossRef
78.
Zurück zum Zitat Zamora KV, Males JJ (2009) Polymicrobial keratitis after a collagen crosslinking procedure with postoperative use of a contact lens: a case report. Cornea 28:474–476PubMedCrossRef Zamora KV, Males JJ (2009) Polymicrobial keratitis after a collagen crosslinking procedure with postoperative use of a contact lens: a case report. Cornea 28:474–476PubMedCrossRef
79.
Zurück zum Zitat Vinciguerra P, Albe E, Trazza S et al (2009) Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 116:369–378PubMedCrossRef Vinciguerra P, Albe E, Trazza S et al (2009) Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 116:369–378PubMedCrossRef
80.
Zurück zum Zitat Caporossi A, Mazzotta C, Baiocchi S et al (2010) Long-term results of riboflavin ultraviolet corneal cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 149:585–593PubMedCrossRef Caporossi A, Mazzotta C, Baiocchi S et al (2010) Long-term results of riboflavin ultraviolet corneal cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 149:585–593PubMedCrossRef
81.
Zurück zum Zitat Buzzonetti L, Petrocelli G, Valente P et al (2015) Ionophoretic transepithelial CXL to halt keratoconus in pediatric cases. Cornea 34:512–515PubMedCrossRef Buzzonetti L, Petrocelli G, Valente P et al (2015) Ionophoretic transepithelial CXL to halt keratoconus in pediatric cases. Cornea 34:512–515PubMedCrossRef
82.
Zurück zum Zitat Magli A, Forte R, Tortori A et al (2013) Epithelium-off corneal collagen cross-linking versus transepithelial cross-linking for pediatric keratoconus. Cornea 32:597–601PubMedCrossRef Magli A, Forte R, Tortori A et al (2013) Epithelium-off corneal collagen cross-linking versus transepithelial cross-linking for pediatric keratoconus. Cornea 32:597–601PubMedCrossRef
83.
Zurück zum Zitat Caporossi A, Mazzotta C, Paradiso A et al (2013) Transepithelial corneal collagen crosslinking for progressive keratoconus: 24 month clinical results. J Cataract Refract Surg 39:1157–1163PubMedCrossRef Caporossi A, Mazzotta C, Paradiso A et al (2013) Transepithelial corneal collagen crosslinking for progressive keratoconus: 24 month clinical results. J Cataract Refract Surg 39:1157–1163PubMedCrossRef
84.
Zurück zum Zitat Ag S (2016) Corneal Biomechanical and anterior chamber parameteres variations after 1-year of transepithelial corneal cross-linking in eyes of children with keratoconus. Middle East Afr J Ophthlamol 23:129–134CrossRef Ag S (2016) Corneal Biomechanical and anterior chamber parameteres variations after 1-year of transepithelial corneal cross-linking in eyes of children with keratoconus. Middle East Afr J Ophthlamol 23:129–134CrossRef
85.
Zurück zum Zitat Erasalan M, Toker E, Cerman E et al (2016) Efficacy of epithelium-off and epithelium-on corneal cross linking in pediatric keratoconus. Eye Contact Lens 43:155–161CrossRef Erasalan M, Toker E, Cerman E et al (2016) Efficacy of epithelium-off and epithelium-on corneal cross linking in pediatric keratoconus. Eye Contact Lens 43:155–161CrossRef
86.
Zurück zum Zitat Alio JL, Shabayek MH, Artola A (2006) Intracorneal ring segments for keratoconus correction: long term follow-up. J Cataract Refract Surg 32:978–985PubMedCrossRef Alio JL, Shabayek MH, Artola A (2006) Intracorneal ring segments for keratoconus correction: long term follow-up. J Cataract Refract Surg 32:978–985PubMedCrossRef
87.
Zurück zum Zitat Dirani A, Fadlallah A, Khoueir Z et al (2013) Safety and efficacy of intacts intracorneal ring segment implantation to improve best corrected visual acuity in children with keratoconus. Eur Soc Cataract and Refract Surg (Abstract) Amsterdam, Netherlands Dirani A, Fadlallah A, Khoueir Z et al (2013) Safety and efficacy of intacts intracorneal ring segment implantation to improve best corrected visual acuity in children with keratoconus. Eur Soc Cataract and Refract Surg (Abstract) Amsterdam, Netherlands
88.
Zurück zum Zitat Antoun J, Slim E, El Rami H et al (2015) Pediatric keratoconus in a tertiary referral center: prevalence, presentation, risk factors and treatment. Eur Soc Cataract Refract Surg Antoun J, Slim E, El Rami H et al (2015) Pediatric keratoconus in a tertiary referral center: prevalence, presentation, risk factors and treatment. Eur Soc Cataract Refract Surg
89.
Zurück zum Zitat Coskunseven E, Jankov MR II, Hafezi F et al (2009) Effect of treatment sequence in combined intrastromal corneal rings and corneal collagen crosslinking for keratoconus. J Cataract Refract Surg 35:2084–2091PubMedCrossRef Coskunseven E, Jankov MR II, Hafezi F et al (2009) Effect of treatment sequence in combined intrastromal corneal rings and corneal collagen crosslinking for keratoconus. J Cataract Refract Surg 35:2084–2091PubMedCrossRef
90.
Zurück zum Zitat El-Raggal TM (2011) Effect of corneal collagen crosslinking on femtosecond laser channel creation for intrastromal corneal ring segment implantation in keratoconus. J Cataract Refract Surg 37:701–705PubMedCrossRef El-Raggal TM (2011) Effect of corneal collagen crosslinking on femtosecond laser channel creation for intrastromal corneal ring segment implantation in keratoconus. J Cataract Refract Surg 37:701–705PubMedCrossRef
91.
Zurück zum Zitat Kilic A, Kamburoglu G, Akinci A (2012) Riboflavin injection into the corneal channel for combined collagen crosslinking and intrastromal corneal ring segment implantation. J Cataract Refract Surg 38:878–883PubMedCrossRef Kilic A, Kamburoglu G, Akinci A (2012) Riboflavin injection into the corneal channel for combined collagen crosslinking and intrastromal corneal ring segment implantation. J Cataract Refract Surg 38:878–883PubMedCrossRef
92.
Zurück zum Zitat Yeung SN, Low SA, Ku JY et al (2013) Transepithelial phototherapeutic keratectomy combined with implantation of a single inferior intrastromal corneal ring segment and collagen crosslinking in keratoconus. J Cataract Refract Surg 39:1152–1156PubMedCrossRef Yeung SN, Low SA, Ku JY et al (2013) Transepithelial phototherapeutic keratectomy combined with implantation of a single inferior intrastromal corneal ring segment and collagen crosslinking in keratoconus. J Cataract Refract Surg 39:1152–1156PubMedCrossRef
93.
Zurück zum Zitat Gaster RN, Caiado Canedo AL, Rabinowitz YS (2013) Corneal collagen cross-linking for keratoconus and post-LASIK ectasia. Int Ophthalmol Clin 53:79–90PubMedPubMedCentralCrossRef Gaster RN, Caiado Canedo AL, Rabinowitz YS (2013) Corneal collagen cross-linking for keratoconus and post-LASIK ectasia. Int Ophthalmol Clin 53:79–90PubMedPubMedCentralCrossRef
94.
Zurück zum Zitat Ertan A, Kamburoglu G, Bahadir M (2006) Intacs insertion with the femtosecond laser for the management of keratoconus. One year results. J Cataract Refract Surg 32:2039–2042PubMedCrossRef Ertan A, Kamburoglu G, Bahadir M (2006) Intacs insertion with the femtosecond laser for the management of keratoconus. One year results. J Cataract Refract Surg 32:2039–2042PubMedCrossRef
95.
Zurück zum Zitat Kanellopuolos AJ, Pe LH, Perry HD et al (2006) Modified intracorneal ring segment implantations (Intacs) for the management of moderate to advanced keratoconus. Efficacy and complications. Cornea 25:29–33CrossRef Kanellopuolos AJ, Pe LH, Perry HD et al (2006) Modified intracorneal ring segment implantations (Intacs) for the management of moderate to advanced keratoconus. Efficacy and complications. Cornea 25:29–33CrossRef
96.
Zurück zum Zitat Kwitko S, Severo NS (2004) Ferrara intracorneal ring segments for keratoconus. J Cataract Refract Surg 30:812–820PubMedCrossRef Kwitko S, Severo NS (2004) Ferrara intracorneal ring segments for keratoconus. J Cataract Refract Surg 30:812–820PubMedCrossRef
97.
Zurück zum Zitat Shetty R, Kurian M, Anand D et al (2008) Intacs in advanced keratoconus. Cornea 27:1022–1029PubMedCrossRef Shetty R, Kurian M, Anand D et al (2008) Intacs in advanced keratoconus. Cornea 27:1022–1029PubMedCrossRef
98.
Zurück zum Zitat Ertan A, Kamburoglu G, Bahadir M (2008) Intacts implantation using femtosecond laser for management of keratoconus: comparison of 306 cases in different stages. J Cataract Refract Surg 34:1521–1526PubMedCrossRef Ertan A, Kamburoglu G, Bahadir M (2008) Intacts implantation using femtosecond laser for management of keratoconus: comparison of 306 cases in different stages. J Cataract Refract Surg 34:1521–1526PubMedCrossRef
99.
Zurück zum Zitat Shabayek MH, Alio JL (2007) Intrastromal corneal ring segment implantation by femtosecond laser for keratoconus correction. Ophthalmology 114:1643–1652PubMedCrossRef Shabayek MH, Alio JL (2007) Intrastromal corneal ring segment implantation by femtosecond laser for keratoconus correction. Ophthalmology 114:1643–1652PubMedCrossRef
100.
Zurück zum Zitat Zare MA, Hasemi H, Salari MR (2007) Intracorneal ring segment implantation for management of keratoconus: safety and efficacy. J Cataract Refract Surg 33:1886–1891PubMedCrossRef Zare MA, Hasemi H, Salari MR (2007) Intracorneal ring segment implantation for management of keratoconus: safety and efficacy. J Cataract Refract Surg 33:1886–1891PubMedCrossRef
101.
Zurück zum Zitat Kymionis GD, Siganos CS, Tsiklis NS et al (2007) Long-term follow up of Intacs in keratoconus. Am J Ophthalmol 143:236–244PubMedCrossRef Kymionis GD, Siganos CS, Tsiklis NS et al (2007) Long-term follow up of Intacs in keratoconus. Am J Ophthalmol 143:236–244PubMedCrossRef
102.
Zurück zum Zitat Colin J (2006) Europoean clinical evaluation: use of Intacs for the treatment of keratoconus. J Cataract Refract Surg 32:747–755PubMedCrossRef Colin J (2006) Europoean clinical evaluation: use of Intacs for the treatment of keratoconus. J Cataract Refract Surg 32:747–755PubMedCrossRef
103.
Zurück zum Zitat Siganos CS, Kymionis GD, Kartikis N, Theodorakis MA, Astyrakakis N, Pallikaris IG (2003) Management of keratoconus with Intact. Am J Ophthalmol 135:64–70PubMedCrossRef Siganos CS, Kymionis GD, Kartikis N, Theodorakis MA, Astyrakakis N, Pallikaris IG (2003) Management of keratoconus with Intact. Am J Ophthalmol 135:64–70PubMedCrossRef
104.
Zurück zum Zitat Kymionis GD, Siganos CS, Kounis G et al (2003) Management of post-LASIK corneal ectasia with Intacs inserts. One-year results. Arch Ophthalmol 121:322–326PubMedCrossRef Kymionis GD, Siganos CS, Kounis G et al (2003) Management of post-LASIK corneal ectasia with Intacs inserts. One-year results. Arch Ophthalmol 121:322–326PubMedCrossRef
105.
Zurück zum Zitat Alio JL, Artola A, Hassanein A et al (2005) One or 2 Intacs segments for the correction of keratoconus. J Cataract Refract Surg 31:943–953PubMedCrossRef Alio JL, Artola A, Hassanein A et al (2005) One or 2 Intacs segments for the correction of keratoconus. J Cataract Refract Surg 31:943–953PubMedCrossRef
106.
Zurück zum Zitat Al-Torbak A, Al-Amri A, Wagoner MD (2005) Deep corneal neovascularization after implantation with instrastromal corneal ring segments. Am J Ophthalmol 140:926–927PubMedCrossRef Al-Torbak A, Al-Amri A, Wagoner MD (2005) Deep corneal neovascularization after implantation with instrastromal corneal ring segments. Am J Ophthalmol 140:926–927PubMedCrossRef
107.
Zurück zum Zitat Carrasquillo KG, Rand J (2007) JH T. Intacs for keratoconus and post-LASIK ectasia: mechanical versus femtosecond laser-assisted channel. Cornea 26:956–962PubMedCrossRef Carrasquillo KG, Rand J (2007) JH T. Intacs for keratoconus and post-LASIK ectasia: mechanical versus femtosecond laser-assisted channel. Cornea 26:956–962PubMedCrossRef
108.
Zurück zum Zitat Deobhakta AA, Kymionis GD, Ide T et al (2008) Corneal edema after Intacs implantation with the femtosecond laser. J Cataract Refract Surg 34:174PubMedCrossRef Deobhakta AA, Kymionis GD, Ide T et al (2008) Corneal edema after Intacs implantation with the femtosecond laser. J Cataract Refract Surg 34:174PubMedCrossRef
109.
Zurück zum Zitat Al Suhaibani AH, Al-Rajhi AA, Al-Motowa S et al (2007) Inverse relationship between age and severity sequelae of acute corneal hydrops associated with keratoconus. Br J Ophthalmol 7(9):984–985CrossRef Al Suhaibani AH, Al-Rajhi AA, Al-Motowa S et al (2007) Inverse relationship between age and severity sequelae of acute corneal hydrops associated with keratoconus. Br J Ophthalmol 7(9):984–985CrossRef
110.
Zurück zum Zitat Adachi W, Kinoshita S, Kobayashi Y et al (2001) First mouse model of hereditary keratoconus: androgen dependency and mapping to chromosome 17. Invest Ophthalmol Vis Sci 42:S906 Adachi W, Kinoshita S, Kobayashi Y et al (2001) First mouse model of hereditary keratoconus: androgen dependency and mapping to chromosome 17. Invest Ophthalmol Vis Sci 42:S906
111.
Zurück zum Zitat Bodenmueller M, Goldblum D, Frueh BE (2003) Penetrating keratoplasty in Down’s Syndrome. Klin Monbl Augenheilkd 220:99–102 (in German) PubMedCrossRef Bodenmueller M, Goldblum D, Frueh BE (2003) Penetrating keratoplasty in Down’s Syndrome. Klin Monbl Augenheilkd 220:99–102 (in German) PubMedCrossRef
112.
Zurück zum Zitat Vanathi M, Panda A, Vengayil S et al (2009) Pediatric keratoplasaty. Surv Ophthalmol 54(2):245–271PubMedCrossRef Vanathi M, Panda A, Vengayil S et al (2009) Pediatric keratoplasaty. Surv Ophthalmol 54(2):245–271PubMedCrossRef
113.
Zurück zum Zitat Huang C, O’Hara M, Mannis MJ (2009) Primary pediatric keratoplasty: indications and outcomes. Cornea 28(9):1003–1008PubMedCrossRef Huang C, O’Hara M, Mannis MJ (2009) Primary pediatric keratoplasty: indications and outcomes. Cornea 28(9):1003–1008PubMedCrossRef
Metadaten
Titel
Pediatric keratoconus: a review of the literature
verfasst von
Sabrina Mukhtar
Balamurali K. Ambati
Publikationsdatum
29.08.2017
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 5/2018
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0699-8

Weitere Artikel der Ausgabe 5/2018

International Ophthalmology 5/2018 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.