Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
Child's Nervous System
Erschienen in: Child's Nervous System 11/2019

13.07.2019 | Focus Session

Pediatric pituitary adenomas

verfasst von: Patrick C. Walz, Annie Drapeau, Ammar Shaikhouni, Jacob Eide, Alex J. Rugino, Ahmed Mohyeldin, Ricardo Carrau, Daniel Prevedello

Erschienen in: Child's Nervous System | Ausgabe 11/2019

Einloggen, um Zugang zu erhalten

Abstract

Background

Pediatric pituitary adenomas are a rare medical entity that makes up a small portion of intracranial tumors in children and adolescents. Although benign, the majority of these lesions are secreting functional tumors with the potential for physiological sequela that can profoundly affect a child’s development.

Focus of Review

In this review, we discuss the medical and surgical management of these tumors with a focus on clinical presentation, diagnostic identification, surgical approach, and associated adjuvant therapies. We will also discuss our current treatment paradigm using endoscopic, open, and combined approaches to treat these tumors.

Summary

The management of pituitary tumors requires a multidisciplinary team of surgeons, endocrinologists, and neuroanesthesiologists as well as neurocritical care specialists to deliver comprehensive care.
Literatur
1.
Espay AJ, Azzarelli B, Williams LS, Bodensteiner JB (2001) Recurrence in pituitary adenomas in childhood and adolescence. J Child Neurol 16(5):364–367CrossRefPubMed
2.
Mindermann T, Wilson CB (1995) Pediatric pituitary adenomas. Neurosurgery. 36(2):259–268 discussion 269CrossRefPubMed
3.
Laws ER, Scheithauer BW, Groover RV (1987) Pituitary adenomas in childhood and adolescence. Prog Exp Tumor Res 30:359–361CrossRefPubMed
4.
Rosemberg S, Fujiwara D (2005) Epidemiology of pediatric tumors of the nervous system according to the WHO 2000 classification: a report of 1,195 cases from a single institution. Childs Nerv Syst 21(11):940–944CrossRefPubMed
5.
Barzaghi LR, Losa M, Capitanio JF, Albano L, Weber G, Mortini P (2018) Pediatric pituitary adenomas: early and long-term surgical outcome in a series of 85 consecutive patients. Neurosurgery.
6.
Perry A, Graffeo CS, Marcellino C, Pollock BE, Wetjen NM, Meyer FB (2018) Pediatric pituitary adenoma: case series, review of the literature, and a skull base treatment paradigm. J Neurol Surg B Skull Base 79(1):91–114CrossRefPubMedPubMedCentral
7.
Dyer EH, Civit T, Visot A, Delalande O, Derome P (1994) Transsphenoidal surgery for pituitary adenomas in children. Neurosurgery. 34(2):207–212 discussion 212CrossRefPubMed
8.
Lafferty AR, Chrousos GP (1999) Pituitary tumors in children and adolescents. J Clin Endocrinol Metab 84(12):4317–4323CrossRefPubMed
9.
Kunwar S, Wilson CB (1999) Pediatric pituitary adenomas. J Clin Endocrinol Metab 84(12):4385–4389CrossRefPubMed
10.
Keil MF, Stratakis CA (2008) Pituitary tumors in childhood: update of diagnosis, treatment and molecular genetics. Expert Rev Neurother 8(4):563–574CrossRefPubMedPubMedCentral
11.
12.
Harrington MH, Casella SJ (2012) Pituitary tumors in childhood. Curr Opin Endocrinol Diabetes Obes 19(1):63–67CrossRefPubMed
13.
Mehta A, Dattani MT (2008) Developmental disorders of the hypothalamus and pituitary gland associated with congenital hypopituitarism. Best Pract Res Clin Endocrinol Metab 22(1):191–206CrossRefPubMed
14.
Kioussi C, O’Connell S, St-Onge L, Treier M, Gleiberman AS, Gruss P, Rosenfeld MG (1999) Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci U S A 96(25):14378–14382CrossRefPubMedPubMedCentral
15.
16.
Colao A, Loche S, Cappa M, di Sarno A, Landi ML, Sarnacchiaro F, Facciolli G, Lombardi G (1998) Prolactinomas in children and adolescents. Clinical presentation and long-term follow-up. J Clin Endocrinol Metab 83(8):2777–2780CrossRefPubMed
17.
18.
Fideleff HL, Boquete HR, Sequera A, Suarez M, Sobrado P, Giaccio A (2000) Peripubertal prolactinomas: clinical presentation and long-term outcome with different therapeutic approaches. J Pediatr Endocrinol Metab 13(3):261–267CrossRefPubMed
19.
Joshi SM, Hewitt RJ, Storr HL et al (2005) Cushing’s disease in children and adolescents: 20 years of experience in a single neurosurgical center. Neurosurgery. 57(2):281–285 discussion 281-285CrossRefPubMed
20.
Lonser RR, Wind JJ, Nieman LK, Weil RJ, DeVroom HL, Oldfield EH (2013) Outcome of surgical treatment of 200 children with Cushing’s disease. J Clin Endocrinol Metab 98(3):892–901CrossRefPubMedPubMedCentral
21.
Magiakou MA, Mastorakos G, Oldfield EH, Gomez MT, Doppman JL, Cutler GB Jr, Nieman LK, Chrousos GP (1994) Cushing’s syndrome in children and adolescents. Presentation, diagnosis, and therapy. N Engl J Med 331(10):629–636CrossRefPubMed
22.
Yordanova G, Martin L, Afshar F, Sabin I, Alusi G, Plowman NP, Riddoch F, Evanson J, Matson M, Grossman AB, Akker SA, Monson JP, Drake WM, Savage MO, Storr HL (2016) Long-term outcomes of children treated for Cushing’s disease: a single center experience. Pituitary. 19(6):612–624CrossRefPubMedPubMedCentral
23.
Abe T, Tara LA, Ludecke DK (1999) Growth hormone-secreting pituitary adenomas in childhood and adolescence: features and results of transnasal surgery. Neurosurgery. 45(1):1–10CrossRefPubMed
24.
Brucker-Davis F, Oldfield EH, Skarulis MC, Doppman JL, Weintraub BD (1999) Thyrotropin-secreting pituitary tumors: diagnostic criteria, thyroid hormone sensitivity, and treatment outcome in 25 patients followed at the National Institutes of Health. J Clin Endocrinol Metab 84(2):476–486CrossRefPubMed
25.
Beck-Peccoz P, Brucker-Davis F, Persani L, Smallridge RC, Weintraub BD (1996) Thyrotropin-secreting pituitary tumors. Endocr Rev 17(6):610–638PubMed
26.
Kane LA, Leinung MC, Scheithauer BW et al (1994) Pituitary adenomas in childhood and adolescence. J Clin Endocrinol Metab 79(4):1135–1140PubMed
27.
Partington MD, Davis DH, Laws ER Jr, Scheithauer BW (1994) Pituitary adenomas in childhood and adolescence. Results of transsphenoidal surgery. J Neurosurg 80(2):209–216CrossRefPubMed
28.
Webb C, Prayson RA (2008) Pediatric pituitary adenomas. Arch Pathol Lab Med 132(1):77–80PubMed
29.
Jankowski PP, Crawford JR, Khanna P, Malicki DM, Ciacci JD, Levy ML (2015) Pituitary tumor apoplexy in adolescents. World Neurosurg 83(4):644–651CrossRefPubMed
30.
Mohr G, Hardy J (1982) Hemorrhage, necrosis, and apoplexy in pituitary adenomas. Surg Neurol 18(3):181–189CrossRefPubMed
31.
32.
Chanson P, Lepeintre JF, Ducreux D (2004) Management of pituitary apoplexy. Expert Opin Pharmacother 5(6):1287–1298CrossRefPubMed
33.
Delman BN (2009) Imaging of pediatric pituitary abnormalities. Endocrinol Metab Clin N Am 38(4):673–698CrossRef
34.
Oldfield EH, Doppman JL, Nieman LK, Chrousos GP, Miller DL, Katz DA, Cutler GB Jr, Loriaux DL (1991) Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing’s syndrome. N Engl J Med 325(13):897–905CrossRefPubMed
35.
Zimmerman RA (1990) Imaging of intrasellar, suprasellar, and parasellar tumors. Semin Roentgenol 25(2):174–197CrossRefPubMed
36.
Arafah BM, Nekl KE, Gold RS, Selman WR (1995) Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. J Clin Endocrinol Metab 80(12):3507–3512PubMed
37.
Barkan AL, Chandler WF (1998) Giant pituitary prolactinoma with falsely low serum prolactin: the pitfall of the “high-dose hook effect”: case report. Neurosurgery. 42(4):913–915 discussion 915-916CrossRefPubMed
38.
Batista DL, Riar J, Keil M, Stratakis CA (2007) Diagnostic tests for children who are referred for the investigation of Cushing syndrome. Pediatrics. 120(3):e575–e586CrossRefPubMed
39.
Orth DN, DeBold CR, DeCherney GS et al (1982) Pituitary microadenomas causing Cushing’s disease respond to corticotropin-releasing factor. J Clin Endocrinol Metab 55(5):1017–1019CrossRefPubMed
40.
Kaltsas GA, Giannulis MG, Newell-Price JD et al (1999) A critical analysis of the value of simultaneous inferior petrosal sinus sampling in Cushing’s disease and the occult ectopic adrenocorticotropin syndrome. J Clin Endocrinol Metab 84(2):487–492PubMed
41.
Stoffel-Wagner B, Springer W, Bidlingmaier F, Klingmuller D (1997) A comparison of different methods for diagnosing acromegaly. Clin Endocrinol 46(5):531–537CrossRef
42.
Carmichael JD, Bonert VS, Mirocha JM, Melmed S (2009) The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly. J Clin Endocrinol Metab 94(2):523–527CrossRefPubMed
43.
Cook DM, Ezzat S, Katznelson L, Kleinberg DL, Laws ER Jr, Nippoldt TB, Swearingen B, Vance ML, AACE Acromegaly Guidelines Task Force (2004) AACE Medical Guidelines for Clinical Practice for the diagnosis and treatment of acromegaly. Endocr Pract 10(3):213–225CrossRefPubMed
44.
Fideleff HL, Boquete HR, Suarez MG, Azaretzky M (2009) Prolactinoma in children and adolescents. Horm Res 72(4):197–205CrossRefPubMed
45.
De Menis E, Visentin A, Billeci D et al (2001) Pituitary adenomas in childhood and adolescence. Clinical analysis of 10 cases. J Endocrinol Investig 24(2):92–97CrossRef
46.
Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA, Endocrine Society (2011) Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(2):273–288CrossRefPubMed
47.
Weiss MH (1981) Medical and surgical management of functional pituitary tumors. Clin Neurosurg 28:374–383CrossRefPubMed
48.
Liu JK, Couldwell WT (2004) Contemporary management of prolactinomas. Neurosurg Focus 16(4):E2CrossRefPubMed
49.
50.
Kassam A, Snyderman CH, Mintz A, Gardner P, Carrau RL (2005) Expanded endonasal approach: the rostrocaudal axis. Part I. Crista galli to the sella turcica. Neurosurg Focus 19(1):E3PubMed
51.
Fujioka M, Young LW (1978) The sphenoidal sinuses: radiographic patterns of normal development and abnormal findings in infants and children. Radiology. 129(1):133–136CrossRefPubMed
52.
Jang YJ, Kim SC (2000) Pneumatization of the sphenoid sinus in children evaluated by magnetic resonance imaging. Am J Rhinol 14(3):181–185CrossRefPubMed
53.
Szolar D, Preidler K, Ranner G, Braun H, Kern R, Wolf G, Stammberger H, Ebner F (1994) Magnetic resonance assessment of age-related development of the sphenoid sinus. Br J Radiol 67(797):431–435CrossRefPubMed
54.
Oliveira RS, Castro M, Antonini SR, Martinelli CE Jr, Moreira AC, Machado HR (2010) Surgical management of pediatric Cushing’s disease: an analysis of 15 consecutive cases at a specialized neurosurgical center. Arq Bras Endocrinol Metabol 54(1):17–23CrossRefPubMed
55.
Locatelli D, Massimi L, Rigante M, Custodi V, Paludetti G, Castelnuovo P, di Rocco C (2010) Endoscopic endonasal transsphenoidal surgery for sellar tumors in children. Int J Pediatr Otorhinolaryngol 74(11):1298–1302CrossRefPubMed
56.
Buchfelder M, Kreutzer J (2008) Transcranial surgery for pituitary adenomas. Pituitary. 11(4):375–384CrossRefPubMed
57.
Dolenc VV (1997) Transcranial epidural approach to pituitary tumors extending beyond the sella. Neurosurgery. 41(3):542–550 discussion 551-542PubMed
58.
Couldwell WT (2004) Transsphenoidal and transcranial surgery for pituitary adenomas. J Neuro-Oncol 69(1–3):237–256CrossRef
59.
Jane JA, Park TS, Pobereskin LH, Winn HR, Butler AB (1982) The supraorbital approach: technical note. Neurosurgery. 11(4):537–542CrossRefPubMed
60.
Snyderman CH, Pant H, Carrau RL, Prevedello D, Gardner P, Kassam AB (2009) What are the limits of endoscopic sinus surgery?: the expanded endonasal approach to the skull base. The Keio journal of medicine 58(3):152–160CrossRefPubMed
61.
Berker M, Hazer DB, Yucel T et al (2012) Complications of endoscopic surgery of the pituitary adenomas: analysis of 570 patients and review of the literature. Pituitary. 15(3):288–300CrossRefPubMed
62.
Bokhari AR, Davies MA, Diamond T (2013) Endoscopic transsphenoidal pituitary surgery: a single surgeon experience and the learning curve. Br J Neurosurg 27(1):44–49CrossRefPubMed
63.
Cappabianca P, Alfieri A, de Divitiis E (1998) Endoscopic endonasal transsphenoidal approach to the sella: towards functional endoscopic pituitary surgery (FEPS). Minim Invasive Neurosurg: MIN 41(2):66–73CrossRefPubMed
64.
Charalampaki P, Ayyad A, Kockro RA, Perneczky A (2009) Surgical complications after endoscopic transsphenoidal pituitary surgery. J Clin Neurosci: official journal of the Neurosurgical Society of Australasia 16(6):786–789CrossRef
65.
Kassam AB, Prevedello DM, Carrau RL, Snyderman CH, Thomas A, Gardner P, Zanation A, Duz B, Stefko ST, Byers K, Horowitz MB (2011) Endoscopic endonasal skull base surgery: analysis of complications in the authors’ initial 800 patients. J Neurosurg 114(6):1544–1568CrossRefPubMed
66.
Prevedello DM, Doglietto F, Jane JA Jr, Jagannathan J, Han J, Laws ER Jr (2007) History of endoscopic skull base surgery: its evolution and current reality. J Neurosurg 107(1):206–213CrossRefPubMed
67.
Massimi L, Rigante M, D’Angelo L et al (2011) Quality of postoperative course in children: endoscopic endonasal surgery versus sublabial microsurgery. Acta Neurochir 153(4):843–849CrossRefPubMed
68.
Chivukula S, Koutourousiou M, Snyderman CH, Fernandez-Miranda JC, Gardner PA, Tyler-Kabara EC (2013) Endoscopic endonasal skull base surgery in the pediatric population. J Neurosurg Pediatr 11(3):227–241CrossRefPubMed
69.
Zhan R, Xu G, Wiebe TM, Li X (2015) Surgical outcomes of the endoscopic transsphenoidal route to pituitary tumours in paediatric patients >10 years of age: 5 years of experience at a single institute. Arch Dis Child 100(8):774–778CrossRefPubMed
70.
Guaraldi F, Storr HL, Ghizzoni L, Ghigo E, Savage MO (2014) Paediatric pituitary adenomas: a decade of change. Hormone research in paediatrics 81(3):145–155CrossRefPubMed
71.
AlQahtani A, Turri-Zanoni M, Dallan I, Battaglia P, Castelnuovo P (2012) Endoscopic endonasal resection of sinonasal and skull base malignancies in children: feasibility and outcomes. Childs Nerv Syst: ChNS : official journal of the International Society for Pediatric Neurosurgery 28(11):1905–1910CrossRef
72.
Shah RN, Surowitz JB, Patel MR, Huang BY, Snyderman CH, Carrau RL, Kassam AB, Germanwala AV, Zanation AM (2009) Endoscopic pedicled nasoseptal flap reconstruction for pediatric skull base defects. Laryngoscope 119(6):1067–1075CrossRefPubMed
73.
Shah MV, Haines SJ (1992) Pediatric skull, skull base, and meningeal tumors. Neurosurg Clin N Am 3(4):893–924CrossRefPubMed
74.
Ghosh A, Hatten K, Learned KO, Rizzi MD, Lee JY, Storm PB, Palmer JN, Adappa ND (2015) Pediatric nasoseptal flap reconstruction for suprasellar approaches. Laryngoscope 125(11):2451–2456CrossRefPubMed
75.
Rastatter JC, Snyderman CH, Gardner PA, Alden TD, Tyler-Kabara E (2015) Endoscopic endonasal surgery for sinonasal and skull base lesions in the pediatric population. Otolaryngol Clin N Am 48(1):79–99CrossRef
76.
Dehdashti AR, Ganna A, Karabatsou K, Gentili F (2008) Pure endoscopic endonasal approach for pituitary adenomas: early surgical results in 200 patients and comparison with previous microsurgical series. Neurosurgery. 62(5):1006–1015 discussion 1015-1007CrossRefPubMed
77.
O’Malley BW Jr, Grady MS, Gabel BC et al (2008) Comparison of endoscopic and microscopic removal of pituitary adenomas: single-surgeon experience and the learning curve. Neurosurg Focus 25(6):E10CrossRefPubMed
78.
Brown SM, Anand VK, Tabaee A, Schwartz TH (2007) Role of perioperative antibiotics in endoscopic skull base surgery. Laryngoscope 117(9):1528–1532CrossRefPubMed
79.
de Almeida JR, Snyderman CH, Gardner PA, Carrau RL, Vescan AD (2011) Nasal morbidity following endoscopic skull base surgery: a prospective cohort study. Head Neck 33(4):547–551CrossRefPubMed
80.
Tien DA, Stokken JK, Recinos PF, Woodard TD, Sindwani R (2016) Cerebrospinal fluid diversion in endoscopic skull base reconstruction: an evidence-based approach to the use of lumbar drains. Otolaryngol Clin N Am 49(1):119–129CrossRef
81.
Zwagerman NT, Wang EW, Shin SS, Chang YF, Fernandez-Miranda JC, Snyderman CH, Gardner PA (2018) Does lumbar drainage reduce postoperative cerebrospinal fluid leak after endoscopic endonasal skull base surgery? A prospective, randomized controlled trial. J Neurosurg 1:1–7
82.
Tien DA, Stokken JK, Recinos PF, Woodard TD, Sindwani R (2016) Comprehensive postoperative management after endoscopic skull base surgery. Otolaryngol Clin N Am 49(1):253–263CrossRef
83.
Benveniste RJ, King WA, Walsh J, Lee JS, Delman BN, Post KD (2005) Repeated transsphenoidal surgery to treat recurrent or residual pituitary adenoma. J Neurosurg 102(6):1004–1012CrossRefPubMed
84.
Ram Z, Nieman LK, Cutler GB Jr, Chrousos GP, Doppman JL, Oldfield EH (1994) Early repeat surgery for persistent Cushing’s disease. J Neurosurg 80(1):37–45CrossRefPubMed
85.
Storr HL, Plowman PN, Carroll PV, François I, Krassas GE, Afshar F, Besser GM, Grossman AB, Savage MO (2003) Clinical and endocrine responses to pituitary radiotherapy in pediatric Cushing’s disease: an effective second-line treatment. J Clin Endocrinol Metab 88(1):34–37CrossRefPubMed
86.
Kanter AS, Diallo AO, Jane JA Jr et al (2005) Single-center experience with pediatric Cushing’s disease. J Neurosurg 103(5 Suppl):413–420PubMed
87.
Follin C, Erfurth EM (2016) Long-term effect of cranial radiotherapy on pituitary-hypothalamus area in childhood acute lymphoblastic leukemia survivors. Curr Treat Options in Oncol 17(9):50CrossRef
88.
Sklar CA, Constine LS (1995) Chronic neuroendocrinological sequelae of radiation therapy. Int J Radiat Oncol Biol Phys 31(5):1113–1121CrossRefPubMed
89.
Constine LS, Woolf PD, Cann D, Mick G, McCormick K, Raubertas RF, Rubin P (1993) Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med 328(2):87–94CrossRefPubMed
90.
Di Ieva A, Rotondo F, Syro LV, Cusimano MD, Kovacs K (2014) Aggressive pituitary adenomas--diagnosis and emerging treatments. Nat Rev Endocrinol 10(7):423–435CrossRefPubMed
91.
Storr HL, Savage MO (2015) Management of endocrine disease: paediatric Cushing’s disease. Eur J Endocrinol 173(1):R35–R45CrossRefPubMed
92.
Baskin DS, Boggan JE, Wilson CB (1982) Transsphenoidal microsurgical removal of growth hormone-secreting pituitary adenomas. A review of 137 cases. J Neurosurg 56(5):634–641CrossRefPubMed
93.
Sudhakar N, Ray A, Vafidis JA (2004) Complications after trans-sphenoidal surgery: our experience and a review of the literature. Br J Neurosurg 18(5):507–512CrossRefPubMed
94.
95.
Hoorn EJ, Zietse R (2010) Water balance disorders after neurosurgery: the triphasic response revisited. NDT plus 3(1):42–44PubMed
96.
Crock PA, Ludecke DK, Knappe UJ, Saeger W (2018) A personal series of 100 children operated for Cushing’s disease (CD): optimizing minimally invasive diagnosis and transnasal surgery to achieve nearly 100% remission including reoperations. J Pediatr Endocrinol Metab: JPEM 31(9):1023–1031CrossRefPubMed
97.
Cappabianca P, Cavallo LM, Colao A, de Divitiis E (2002) Surgical complications associated with the endoscopic endonasal transsphenoidal approach for pituitary adenomas. J Neurosurg 97(2):293–298CrossRefPubMed
98.
Perry A, Graffeo CS, Copeland WR 3rd et al (2017) Delayed cerebrospinal fluid rhinorrhea after gamma knife radiosurgery with or without preceding transsphenoidal resection for pituitary pathology. World neurosurgery 100:201–207CrossRefPubMed
99.
Garcia-Navarro V, Anand VK, Schwartz TH (2013) Gasket seal closure for extended endonasal endoscopic skull base surgery: efficacy in a large case series. World neurosurgery 80(5):563–568CrossRefPubMed
100.
Kassam AB, Thomas A, Carrau RL et al (2008) Endoscopic reconstruction of the cranial base using a pedicled nasoseptal flap. Neurosurgery 63(1 Suppl 1):ONS44–ONS52 discussion ONS52-43PubMed
101.
Zhang Y, Tian Z, Li C et al (2019) A modified endovascular treatment protocol for iatrogenic internal carotid artery injuries following endoscopic endonasal surgery. J Neurosurg 25:1–8
Metadaten
Titel
Pediatric pituitary adenomas
verfasst von
Patrick C. Walz
Annie Drapeau
Ammar Shaikhouni
Jacob Eide
Alex J. Rugino
Ahmed Mohyeldin
Ricardo Carrau
Daniel Prevedello
Publikationsdatum
13.07.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Child's Nervous System / Ausgabe 11/2019
Print ISSN: 0256-7040
Elektronische ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-019-04293-y

Weitere Artikel der Ausgabe 11/2019

Child's Nervous System 11/2019 Zur Ausgabe

Letter to the Editor

Spontaneous rupture: a rare complication of neglected hydrocephalus

Focus Session

Pediatric craniopharyngioma

Focus Session

Transsphenoidal surgery for pituitary adenomas in pediatric patients: a multicentric retrospective study

Focus Session

Endoscopic endonasal skull base surgery for pediatric brain tumors

Focus Session

Endonasal endoscopic skullbase surgery in children

Original Article

Role of follow-up CT scans in the management of traumatic pediatric epidural hematomas

Neu im Fachgebiet Chirurgie

17.04.2024 | Postoperative nausea and vomiting | Nachrichten

Hochrisiko-Eingriffe für postoperative Übelkeit

16.04.2024 | HNO-Chirurgie | Nachrichten

HNO-Op. auch mit über 90?

16.04.2024 | Infektiologie | Nachrichten

Kein Abstrich bei chronischen Wunden ohne Entzündungszeichen!

10.04.2024 | Postoperative Schmerztherapie | Nachrichten

Chronische Schmerzen nach Op. oft mit neuropathischer Komponente
weitere anzeigen

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Aktuelle BDC Leitlinien-Webinare

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom CME-Kurs
CME: 2 Punkte

Prof. Dr. med. Gregor Antoniadis Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur CME-Kurs
CME: 2 Punkte

Dr. med. Benjamin Meyknecht, PD Dr. med. Oliver Pieske Das Webinar S2e-Leitlinie „Distale Radiusfraktur“ beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis CME-Kurs
CME: 2 Punkte

Dr. med. Mihailo Andric
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.