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Erschienen in: Uro-News 3/2022

07.03.2022 | Peniskarzinom | Zertifizierte Fortbildung

Selten und komplex

Diagnostik und Therapie des Peniskarzinoms

verfasst von: Richard Kutschke, Prof. Dr. med. habil. Oliver W. Hakenberg, Prof. Dr. med. Chris Protzel

Erschienen in: Uro-News | Ausgabe 3/2022

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Aufgrund der geringen Inzidenz des Peniskarzinoms ist die Datenlage zur Diagnostik und Therapie ausgesprochen schlecht. Ziel der Behandlung ist eine komplette Entfernung des Tumors mit möglichst organerhaltendem oder rekonstruktivem Ansatz. Da Peniskarzinome besonders früh metastasieren, ist auch ein suffizientes Lymphknotenmanagement von zentraler Bedeutung. …
Literatur
1.
Zurück zum Zitat Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF): S3-Leitlinie Diagnostik, Therapie und Nachsorge des Peniskarzinoms, Langversion 1.0, 2020, AWMF Registernummer: 043-042OL, https://​www.​leitlinienprogra​mm-onkologie.​de/​leitlinien/​peniskarzinom/​ Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF): S3-Leitlinie Diagnostik, Therapie und Nachsorge des Peniskarzinoms, Langversion 1.0, 2020, AWMF Registernummer: 043-042OL, https://​www.​leitlinienprogra​mm-onkologie.​de/​leitlinien/​peniskarzinom/​
2.
Zurück zum Zitat Sri D et al. A study into the association between local recurrence rates and surgical resection margins in organsparing surgery for penile squamous cell cancer. BJU int. 2018; 122: 576-82 Sri D et al. A study into the association between local recurrence rates and surgical resection margins in organsparing surgery for penile squamous cell cancer. BJU int. 2018; 122: 576-82
3.
Zurück zum Zitat Parkin DM WS et al. Cancer Incidence in Five Continents. IARC Scientific Publications No155. Lyon, France: IARC; 2002 Parkin DM WS et al. Cancer Incidence in Five Continents. IARC Scientific Publications No155. Lyon, France: IARC; 2002
4.
Zurück zum Zitat Dillner J et al. Etiology of squamous cell carcinoma of the penis. Scand J Urol Nephrol Suppl. 2000; 205: 189-93 Dillner J et al. Etiology of squamous cell carcinoma of the penis. Scand J Urol Nephrol Suppl. 2000; 205: 189-93
5.
Zurück zum Zitat Madsen BS et al. Risk factors for squamous cell carcinoma of the penis - population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev. 2008; 17: 2683-91 Madsen BS et al. Risk factors for squamous cell carcinoma of the penis - population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev. 2008; 17: 2683-91
6.
Zurück zum Zitat Favorito LA et al. Epidemiologic study on penile cancer in Brazil. Int Braz J Urol. 2008; 34: 587-91 Favorito LA et al. Epidemiologic study on penile cancer in Brazil. Int Braz J Urol. 2008; 34: 587-91
7.
Zurück zum Zitat Harish K et al. The role of tobacco in penile carcinoma. Br J Urol. 1995; 75: 375-7 Harish K et al. The role of tobacco in penile carcinoma. Br J Urol. 1995; 75: 375-7
8.
Zurück zum Zitat Rubin MA et al. Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol. 2001; 159: 1211-8 Rubin MA et al. Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol. 2001; 159: 1211-8
9.
Zurück zum Zitat Cubilla AL et al. Tumours of the penis. In: Eble JN et al. (Hrsg.) World Health Organization Classification of tumours Pathology and genetics of tumours of the urinary system and male genital organs. Lyon, France: IARC Press; 2004 Cubilla AL et al. Tumours of the penis. In: Eble JN et al. (Hrsg.) World Health Organization Classification of tumours Pathology and genetics of tumours of the urinary system and male genital organs. Lyon, France: IARC Press; 2004
10.
Zurück zum Zitat Sobin LH et al. TNM Classification of Malignant Tumours. UICC International Union Against Cancer 7th Edition edn. New York: Wiley-Blackwell; 2009 Sobin LH et al. TNM Classification of Malignant Tumours. UICC International Union Against Cancer 7th Edition edn. New York: Wiley-Blackwell; 2009
11.
Zurück zum Zitat Poetsch M et al. Screening of microsatellite markers in penile cancer reveals differences between metastatic and nonmetastatic carcinomas. Mod Pathol. 2007; 20: 1069-77 Poetsch M et al. Screening of microsatellite markers in penile cancer reveals differences between metastatic and nonmetastatic carcinomas. Mod Pathol. 2007; 20: 1069-77
12.
Zurück zum Zitat Poetsch M et al. Alterations in the tumor suppressor gene p16(INK4A) are associated with aggressive behavior of penile carcinomas. Virchows Arch. 2011; 458: 221-9 Poetsch M et al. Alterations in the tumor suppressor gene p16(INK4A) are associated with aggressive behavior of penile carcinomas. Virchows Arch. 2011; 458: 221-9
13.
Zurück zum Zitat Martins AC et al. Immunoexpression of p53 protein and proliferating cell nuclear antigen in penile carcinoma. J Urol. 2002; 167: 89-92 Martins AC et al. Immunoexpression of p53 protein and proliferating cell nuclear antigen in penile carcinoma. J Urol. 2002; 167: 89-92
14.
Zurück zum Zitat Hakenberg O et al. EAU giudelines on penile cancer: 2014 update. Eur Urol. 2014; 67: 142-50 Hakenberg O et al. EAU giudelines on penile cancer: 2014 update. Eur Urol. 2014; 67: 142-50
15.
Zurück zum Zitat Kayes O et al. The role of magnetic resonance imaging in the local staging of penile cancer. Eur Urol. 2007; 51: 1313-8 Kayes O et al. The role of magnetic resonance imaging in the local staging of penile cancer. Eur Urol. 2007; 51: 1313-8
16.
Zurück zum Zitat Velazquez EF et al. Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma. Int J Surg Pathol. 2004; 12: 139-46 Velazquez EF et al. Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma. Int J Surg Pathol. 2004; 12: 139-46
17.
Zurück zum Zitat Protzel C et al. Lymphadenectomy in the surgical management of penile cancer. Eur Urol. 2009; 55: 1075-88 Protzel C et al. Lymphadenectomy in the surgical management of penile cancer. Eur Urol. 2009; 55: 1075-88
18.
Zurück zum Zitat Kroon BK et al. Patients with penile carcinoma benefit from immediate resection of clinically occult lymph node metastases. J Urol. 2005; 173: 816-9 Kroon BK et al. Patients with penile carcinoma benefit from immediate resection of clinically occult lymph node metastases. J Urol. 2005; 173: 816-9
19.
Zurück zum Zitat Saisorn I et al. Fine-needle aspiration cytology predicts inguinal lymph node metastasis without antibiotic pretreatment in penile carcinoma. BJU Int. 2006; 97: 1225-8 Saisorn I et al. Fine-needle aspiration cytology predicts inguinal lymph node metastasis without antibiotic pretreatment in penile carcinoma. BJU Int. 2006; 97: 1225-8
20.
Zurück zum Zitat Scher B et al. 18F-FDG PET/CT for staging of penile cancer. J Nucl Med. 2005; 46: 1460-5 Scher B et al. 18F-FDG PET/CT for staging of penile cancer. J Nucl Med. 2005; 46: 1460-5
21.
Zurück zum Zitat Leijte JA et al. Recurrence patterns of squamous cell carcinoma of the penis: recommendations for follow-up based on a two-centre analysis of 700 patients. Eur Urol. 2008; 54: 161-8 Leijte JA et al. Recurrence patterns of squamous cell carcinoma of the penis: recommendations for follow-up based on a two-centre analysis of 700 patients. Eur Urol. 2008; 54: 161-8
22.
Zurück zum Zitat Minhas S et al. What surgical resection margins are required to achieve oncological control in men with primary penile cancer? BJU Int. 2005; 96: 1040-3 Minhas S et al. What surgical resection margins are required to achieve oncological control in men with primary penile cancer? BJU Int. 2005; 96: 1040-3
23.
Zurück zum Zitat Alnajjar HM et al. Treatment of Carcinoma in situ of the Glans Penis with Topical Chemotherapy Agents. Eur Urol. 2012; 62: 923-8 Alnajjar HM et al. Treatment of Carcinoma in situ of the Glans Penis with Topical Chemotherapy Agents. Eur Urol. 2012; 62: 923-8
24.
Zurück zum Zitat Schlenker B et al. Fluorescence-guided laser therapy for penile carcinoma and precancerous lesions: Long-term follow-up. Urol Oncol. 2011; 29: 788-93 Schlenker B et al. Fluorescence-guided laser therapy for penile carcinoma and precancerous lesions: Long-term follow-up. Urol Oncol. 2011; 29: 788-93
25.
Zurück zum Zitat Hegarty PK et al. Penile preserving surgery and surgical strategies to maximize penile form and function in penile cancer: recommendations from the United Kingdom experience. World J Urol. 2009; 27: 179-87 Hegarty PK et al. Penile preserving surgery and surgical strategies to maximize penile form and function in penile cancer: recommendations from the United Kingdom experience. World J Urol. 2009; 27: 179-87
26.
Zurück zum Zitat de Crevoisier R et al. Long-term results of brachytherapy for carcinoma of the penis confined to the glans (N- or NX). Int J Radiat Oncol Biol Phys. 2009; 74: 1150-6 de Crevoisier R et al. Long-term results of brachytherapy for carcinoma of the penis confined to the glans (N- or NX). Int J Radiat Oncol Biol Phys. 2009; 74: 1150-6
27.
Zurück zum Zitat Ficarra V et al. Should the dynamic sentinel node biopsy (DSNB) be considered the gold standard in the evaluation of lymph node status in patients with penile carcinoma? Eur Urol. 2007; 52: 17-9 Ficarra V et al. Should the dynamic sentinel node biopsy (DSNB) be considered the gold standard in the evaluation of lymph node status in patients with penile carcinoma? Eur Urol. 2007; 52: 17-9
28.
Zurück zum Zitat Pizzocaro G et al. Up-to-date management of carcinoma of the penis. Eur Urol. 1997; 32: 5-15 Pizzocaro G et al. Up-to-date management of carcinoma of the penis. Eur Urol. 1997; 32: 5-15
29.
Zurück zum Zitat Dexeus FH et al. Combination chemotherapy with methotrexate, bleomycin and cisplatin for advanced squamous cell carcinoma of the male genital tract. J Urol. 1991; 146: 1284-7 Dexeus FH et al. Combination chemotherapy with methotrexate, bleomycin and cisplatin for advanced squamous cell carcinoma of the male genital tract. J Urol. 1991; 146: 1284-7
30.
Zurück zum Zitat Haas GP et al. Cisplatin, methotrexate and bleomycin for the treatment of carcinoma of the penis: a Southwest Oncology Group study. J Urol. 1999; 161: 1823-5 Haas GP et al. Cisplatin, methotrexate and bleomycin for the treatment of carcinoma of the penis: a Southwest Oncology Group study. J Urol. 1999; 161: 1823-5
31.
Zurück zum Zitat Hakenberg OW et al. Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma. BJU Int. 2006; 98: 1225-7 Hakenberg OW et al. Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma. BJU Int. 2006; 98: 1225-7
32.
Zurück zum Zitat Pizzocaro G et al. Taxanes in Combination with Cisplatin and Fluorouracil for Advanced Penile Cancer: Preliminary Results. Eur Urol. 2009; 55: 546-51 Pizzocaro G et al. Taxanes in Combination with Cisplatin and Fluorouracil for Advanced Penile Cancer: Preliminary Results. Eur Urol. 2009; 55: 546-51
33.
Zurück zum Zitat Pagliaro LC et al. Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol. 28: 3851-7 Pagliaro LC et al. Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol. 28: 3851-7
Metadaten
Titel
Selten und komplex
Diagnostik und Therapie des Peniskarzinoms
verfasst von
Richard Kutschke
Prof. Dr. med. habil. Oliver W. Hakenberg
Prof. Dr. med. Chris Protzel
Publikationsdatum
07.03.2022