Study design and procedure
This was a “real-world” cross-sectional study. A “real-world” study is one that is non-interventional with an unrestricted population, where the basis is the clinical practice and the focus is the need for changes in practice. The sample was composed of 60 consecutive patients (23 with MetS and 37 without) attending the Severe Mental Disorder Program and, more specifically, the Metabolic Syndrome Protocol at a public mental health center in Barcelona, Spain. The inclusion criteria were the following: outpatients who had received antipsychotic medication for at least 12 weeks, had had a blood test in the previous 3 months and had given informed consent. The exclusion criterion was incapacity to understand the questions formulated in Spanish. Those individuals not included in analysis showed no differences with respect to the sample subjects in terms of sociodemographic and clinical characteristics.
Measurement instruments
All patients were evaluated using the following instruments:
A sociodemographic and clinical questionnaire that included information on psychiatric history, comorbidity, anthropometric measurements (weight, height, BMI, waist circumference and blood pressure), metabolic profile (cholesterol, triglycerides and fasting glucose) and lifestyle (diet, physical exercise, substance use) and antipsychotic treatment.
The Positive and Negative Syndrome Scale (PANSS), Spanish version [
37,
38], divided into positive (PANSS-P), negative (PANSS-N) and general (PANSS-G) symptomatology. The psychometric properties of the PANSS are currently well documented showing good validity and reliability with good internal consistency of its five-factor structure (Cronbach’s alpha >0.70) [
37].
The Global Assessment of Functioning (GAF) Scale [
39]. Studies of concurrent validity of the GAF with schizophrenia samples indicate that the GAF is a valid measure of global psychological, social, and occupational functioning [
40].
The EuroQol-5 Dimensions (EQ-5D), Spanish version [
41,
42], divided into 2 sections: 1) a descriptive system that assesses HRQoL in 5 dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), each with 3 levels of severity (value 1 = no problems, value 2 = some problems, value 3 = severe problems); 2) a visual analogue scale (VAS) in the form of a “thermometer” (value 0 = worst and value 100 = best imaginable health status). It describes the self-perception of health on each dimension on the day of administration. In our sample, reliability for the 5 dimensions evaluated was low (Cronbach’s alpha = 0.664), although it is mainly due to the reduced number of items not to inconsistencies of the answers.
The CAN Interview, Spanish version [
1,
9,
43], which evaluates the presence of needs for care in 22 domains in the previous month. The number of total, met and unmet needs can be calculated for each domain and recorded from different perspectives (service user and/or staff or caregiver). We considered the patient’s perspective only. In our sample, Cronbach’s alpha = 0.801 was obtained.
Data analysis
Statistical analyses were performed using the SPSS 20.0 software package (SPSS Inc., Chicago, Illinois, USA) and the significance level used was
p < 0.05 (2-tailed). The EQ-5D dimensions were dichotomized into absent/present (value 1 = absence and value 2 + 3 = presence of problem) and the number of problems was added up under the label “EQ-5D Total Score”. The frequency distributions of met and unmet perceived needs were determined and the mean number of total, met and unmet needs was calculated and compared between the groups with absence/presence of MetS. First, data analyses consisting of the descriptive statistics of all the measurements were done. Subsequently, the Student’s
t-test was used to compare means between continuous variables, the chi-squared test to study the association between nominal variables and the Mantel-Haenszel test for ordinal variables. Pearson correlations were calculated to measure the degree of association between total, met, unmet needs and quality of live, psychotic symptomatology. Given the absence of statistical and clinical differences between patients with and without MetS (Table
1), except for the physical measurements which defines MetS (dyslipidemia, diabetes mellitus), there was no necessity to statistically adjust for any confounding variables.
Table 1
Sociodemographic and clinical variables according to the absence (N = 37)/presence (N = 23) of metabolic syndrome
Age (mean, SD) | 41.7 (10.9) | 46.0 (10.1) | 1.54 | .130 |
Sex (N = 60) | | | .582 | .445 |
Male | 62.2 % | 52.2 % |
Female | 37.8 % | 47.8 % |
Employment Status (N = 60) | | | .353 | .553 |
Active | 18.9 % | 13.0 % |
Unemployed | 81.1 % | 87.0 % |
Living Arrangements | | | .023 | .879 |
Living with parents | 86.5 % | 91.3 % |
Others | 13.5 % | 8.7 % |
Education (N = 60) | | | .244 | .622 |
Primary school | 37.8 % | 43.5 % |
Secondary school | 24.3 % | 17.4 % |
Medium studies (professional college) | 18.9 % | 30.4 % |
University | 18.9 % | 8.7 % |
Years since diagnosis (N = 59) | | | .570 | .450 |
Less than 5 years | 19.4 % | 8.7 % |
5-10 years | 6.0 % | 21.7 % |
10-15 years | 22.2 % | 21.7 % |
More than 15 years | 41.7 % | 47.8 % |
Lifestyle habits (N = 60) | | | | |
Smoking | 56.8 % | 73.9 % | 1.79 | .180 |
Alcoholism | 24.3 % | 26.1 % | .024 | .878 |
Abuse of other substances/drugs(B)
| 29.7 % | 17.4 % | 1.15 | .283 |
Diet (N = 59) | | | | |
Unrestricted calories | 80.6 % | 65.2 % | 1.74 | .187 |
Unrestricted salt | 66.7 % | 56.5 % | .618 | .432 |
Unrestricted fibers | 66.7 % | 65.2 % | .013 | .909 |
Unrestricted saturated fat | 44.4 % | 26.1 % | 2.02 | .155 |
Physical activity | 69.4 % | 65.2 % | .115 | .735 |
Medical history (N = 60) | | | | |
Cardiovascular disease | 2.7 % | 30.4 % | 9.44 | .002 |
Dyslipidemia | 8.1 % | 30.4 % | 5.09 | .024 |
Diabetes mellitus | 13.5 % | 43.5 % | 6.79 | .009 |
Psychopharmacological Treatment (N = 60) | | | | |
Antipsychotics (AP)- Monotherapy | 54.1 % | 30.4 % | 3.19 | .074 |
Antipsychotics (AP)- Polytherapy | 45.9 % | 69.6 % |
Antidepressants (AD) | 40.5 % | 39.1 % | .012 | .914 |
Anxiolytics/Hypnotics (AN) | 59.5 % | 69.6 % | .624 | .430 |
Mood stabilizers (MS) | 32.4 % | 43.5 % | .745 | .388 |
Others(C)
| 21.6 % | 26.1 % | .158 | .691 |
Results
The sociodemographic and clinical characteristics according to the absence/presence of MetS in participants with schizophrenia or schizoaffective disorder are shown in Table
1. The sample was composed mostly of unemployed men living with their parents, with a primary school level of education, who had been diagnosed more than 15 years earlier, had been treated with more than 2 antipsychotics and had a history of diabetes, cardiovascular disease and dyslipidemia. Most of the participants were smokers and did not restrict calorie or salt intake, but were in the habit of eating fibre and engaging in physical activity. We found that MetS was associated with a history of cardiovascular disease (
p = 0.00), diabetes (
p = 0.00) and dyslipidemia (
p = 0.02).
The percentages of needs in the 22 CAN areas rated by the patient and their relation to MetS are given in Table
2. Patients rated a mean of 5.5 total needs (SD = 3.43) with a score of 4 met (SD = 2.48) and 1.5 unmet needs (SD = 1.83). Although there were no significant differences between absence/presence of MetS in the percentages of needs, we found some high values in some domains. In the group with MetS, there were 18.1% fewer patients with no perceived needs in the physical health domain and 18.7 % fewer patients with met needs in the psychotic symptoms domain. On the other hand, we found 25.6 % more patients with met needs in the company domain in the group without MetS.
Table 2
Percentages (%) of subjects with no needs, met needs or unmet needs for 22 CAN domains (user's perspective) and stratified by presence/absence of metabolic syndrome
1. Accommodation | 95.0 | 3.3 | 1.7 | -6.0 | 8.7 | -2.7 | .691 |
2. Food | 56.7 | 33.3 | 10.0 | -0.3 | 2.4 | -2.1 | .917 |
3. Looking after the home | 45.8 | 44.1 | 10.2 | -15 | 2.3 | 12.8 | .120 |
4. Self-care | 86.7 | 11.7 | 1.7 | 0.5 | -4.8 | 4.3 | .718 |
5. Daytime activitiesa
| 52.5 | 25.4 | 22.0 | 13.7 | -13.2 | -0.5 | .516 |
6. Physical health | 63.3 | 30.0 | 6.7 | -18.1 | 7.8 | 10.3 | .084 |
7. Psychotic symptoms | 41.7 | 55.0 | 3.3 | 17.1 | -18.7 | 1.6 | .296 |
8. Informationa
| 85.0 | 11.7 | 1.7 | -10.9 | 9.3 | 4.3 | .844 |
9. Psychological distress | 26.7 | 41.7 | 31.7 | -8.0 | -4.1 | 12.1 | .325 |
10. Safety to self | 85.0 | 11.7 | 3.3 | 3.2 | 2.2 | -5.4 | .491 |
11. Safety to others | 88.3 | 8.3 | 3.3 | 4.8 | -6.5 | 1.6 | .788 |
12. Alcohol | 95.0 | 5.0 | 0.0 | 1.1 | -1.1 | 0.0 | .856 |
13. Drugs | 93.3 | 5.0 | 1.7 | 3.8 | -1.1 | -2.7 | .466 |
14. Companyb
| 50.0 | 23.3 | 25.0 | -17.7 | 25.6 | -12.3 | .265 |
15. Intimate relationshipsb
| 73.3 | 21.7 | 3.3 | -13.2 | 7.2 | 1.6 | .132 |
16. Sexual expressionb
| 71.7 | 15.0 | 10.0 | -10.5 | 3.9 | 4.9 | .526 |
17. Child care | 96.6 | 3.4 | 0.0 | 5.4 | -5.4 | 0.0 | .271 |
18. Basic education | 91.7 | 6.7 | 1.7 | -0.6 | 3.3 | -2.7 | .822 |
19. Telephone | 90.0 | 8.3 | 1.7 | -4.9 | 7.6 | -2.7 | .821 |
20. Transport | 85.0 | 10.0 | 5.0 | -3.9 | -2.1 | 6.0 | .470 |
21. Money | 68.3 | 23.3 | 8.3 | -19.2 | 18.6 | 0.6 | .248 |
22. Welfare benefits | 98.3 | 1.7 | 0.0 | -4.3 | 4.3 | 0.0 | .205 |
As can be seen, in Table
3, there was no association between the number of needs and the presence of MetS. The mean number of total needs of the participants with MetS was 5.95 (SD = 3.97), with a score of 4.26 met (SD = 2.73) and 1.69 unmet needs (SD = 2.20).
Table 3
Comparison of total number of needs, met and unmet needs according to the absence/presence of metabolic syndrome
Total Needs | No | 37 | 5.21 | 3.12 | .425 | -2.58 to 1.10 |
Yes | 23 | 5.95 | 3.97 |
Met Needs | No | 37 | 3.81 | 2.36 | .503 | -1.78 to .885 |
Yes | 23 | 4.26 | 2.73 |
Unmet Needs | No | 37 | 1.40 | 1.58 | .556 | -1.27 to .691 |
Yes | 23 | 1.69 | 2.20 |
The associations between the number of total, met and unmet needs according to the presence/absence of MetS and age, EQ-5D total score, EQ-VAS, GAF and PANSS scores are shown in Table
4. For participants with MetS, age was associated with the number of needs (
p = 0.463) and unmet needs (
p = 0.467). The EQ-5D total score showed no significant association with MetS. However, mobility problems (EQ-5D dimension) were negatively associated with the number of needs (
p = 0.01) and unmet (
p = 0.03) needs. For people with MetS, HRQoL was related to the number of needs (
p = 0.028) and unmet (
p = 0.043) needs. For patients with MetS, the PANSS-P score was related to the number of needs (
p = 0.018) and met needs (
p = 0.020) and PANSS-G was associated with the number of needs (
p = 0.000), met needs (
p = 0.022) and unmet needs (
p = 0.001). The PANSS-N score was not associated with the number of needs in participants with MetS. For individuals without MetS, the GAF score was significantly inversely related to the number of total (
p = 0.005), met (
p = 0.039) and unmet needs (
p = 0.014).
Table 4
Correlations between the perceived needs and age, health-related quality of life(A), global functioning(B) and symptomatology(C), stratified by absence/presence of metabolic syndrome
Total Needs | No | 36 | .103 | .118 | -.200 | -.454* | .052 | .261 | .220 |
Yes | 23 | .463* | .273 | -.457* | -.260 | .490* | .220 | .680* |
Met Needs | No | 36 | .190 | .093 | -.103 | -.346* | .069 | .172 | .092 |
Yes | 23 | .296 | .292 | -.320 | -.299 | .483* | .055 | .475* |
Unmet Needs | No | 36 | -.080 | .102 | -.246 | -.406* | .007 | .270 | .299* |
Yes | 23 | .467* | .129 | -.426* | -.185 | .283 | .328 | .636* |
Discussion
MetS is an important topic for research and clinical practice in the field of schizophrenia. The same is true of the study of QoL and needs assessment, both of which are considered core components of a community-based mental health treatment program. Of all the sociodemographic variables analyzed in our study, age was the only parameter related to needs in the presence of MetS. The older participants with MetS identified more total and unmet needs. Meesters et al. [
44] found that elderly people with schizophrenia reported similar results and they hypothesized that it is probable that changes associated with aging generate new care needs and/or modify existing ones. Looking at the data in detail, we found the higher number of met needs in the environmental and physical domains. We believe that the association between age and perceived needs in our sample can be explained by the effects of a history of cardiovascular disease, diabetes and dyslipidemia. The association between needs and sociodemographic variables is inconsistent [
10,
13,
45].
In our study, we found scores and needs domains similar to those of other studies [
6,
7,
10‐
12,
45,
46]. Arvidsson [
10] found that both staff and patients rated the most common needs in the domains related to psychotic symptoms, psychological distress, looking after the home and company. However, the patients rated a mean score of total needs that was lower than ours. McCrone at al. [
11] provided further comparisons of needs in patients with schizophrenia in 5 different European countries. Despite their specificities, the between-site differences in overall met needs were very small, while unmet needs varied substantially. The majority of the participants from Santander (Spain) were living with their relatives and accommodation was thus not a problem; daytime activities, however, were more frequently reported as a problem than in the other cities. One of the underlying causes may have been the lack of alternative structures for day care and psychosocial rehabilitation. We found that drugs and alcohol in the CAN interview domains are rarely mentioned as areas of need due to a possible underreporting of data by the participants. A description of the most frequently identified unmet needs can be found in the recent review of Torres-González et al. [
25].
In our study, the individuals with MetS identified more perceived needs compared to the group without this condition. However, we found no correlation between the number of needs and the presence of MetS, probably due to the strict control of physical health problems by general practitioners who treat the patients jointly with mental health professionals. We believe that this comprehensive approach minimizes the possible effect of MetS in the perception of needs for care expressed by the participants.
HRQoL did not show a significant association with MetS. However, mobility problems were negatively associated with the number of total, met and unmet needs. While EQ-5D is a generic HRQoL instrument that explores the perception of health on the day of the interview, CAN explores needs over the previous month and this may be a reason for this unexpected result. We came to the conclusion that EQ-5D is probably not suitable for this kind of study because the influence of physical and/or mental problems and acute and/or chronic needs on responses is unclear.
HRQoL was related to the number of total and unmet needs in participants with MetS. A strong relationship exists between unmet needs and QoL [
13,
14,
45,
47,
48]. Hansson and colleagues [
15] found that unmet needs were associated with poorer QoL and Lambri et al. [
16] found that “the observer-rated psychiatric symptom score did not determine QoL, although self-reported psychopathology and social need did”. Meesters et al. [
44] found that unmet needs were associated with poorer QoL in elderly patients with schizophrenia. Although some studies have shown an association between schizophrenia and physical problems (including MetS) and QoL [
21,
30,
49,
50], Medeiros-Ferreira et al. [
23] found no correlation between MetS and HRQoL. They did, however, find that people who engaged in physical activity reported better self-perceived health and this can be understood as a feature of HRQoL.
We found that global functioning was significantly related to needs in participants without MetS. Positive symptomatology was related to the number of total and met needs in people with MetS and general symptomatology was associated with the number of total needs. This finding might be attributable to the fact that our study sample consisted of outpatients whose needs were satisfied by the health care interventions provided with respect to dealing with positive symptoms but not with general symptoms (such as anxiety or depression) associated with perceived needs. Ochoa et al. [
6] and Alvarado et al. [
45] found similar results. However, it was not the aim of these studies to analyze the presence of MetS and its association with needs and HRQoL.
Our findings should be interpreted with caution. This was a cross-sectional study and the fact of the possible overlapping definitions of needs and HRQoL, make it more difficult to address the differences between the influence of one or another on the results. Nevertheless, the association of a higher number of unmet needs with a lower perception of QoL has emerged as a robust finding in other studies [
16,
44,
48,
50]. Further, it has not been possible to analyze the sample with schizophrenia or schizoaffective disorder separately, the same has occurred with the stratification by typical or atypical antipsychotics due to the limited number of patients enrolled in the study. As our sample was composed of outpatients receiving treatment in a public mental health center, the results cannot necessarily be generalized to people with other profiles.
The main strength of our study lies in the fact that it was based on “real-world” clinical practice and exclusively on the participants’ own perceptions of needs. It is well known that the assessment of needs by patients, staff and caregivers provides a more comprehensive evaluation and that mental health interventions must be chosen based on a negotiation process between them [
10,
44,
51]. Although we totally agree with this perspective, we believe that assessing only the perceived needs and HRQoL of individuals suffering from schizophrenia or schizoaffective disorder is a way of empowering them in their own decision-making process in dealing with the illness. Indeed, in public health studies the patient’s perspective sheds light on how people deal with a chronic disease and is given the same importance as the professional perspective. In this respect, we disagree with the administration of the CAN interview only to staff, which is less time-consuming, but may be not sufficient and appropriate for clinical routine.