Skip to main content
Erschienen in: CardioVascular and Interventional Radiology 10/2016

17.05.2016 | Technical Note

Percutaneous MR-Guided Cryoablation of Morton’s Neuroma: Rationale and Technical Details After the First 20 Patients

verfasst von: Roberto Luigi Cazzato, Julien Garnon, Nitin Ramamurthy, Georgia Tsoumakidou, Jean Caudrelier, Marie-Aude Thenint, Pramod Rao, Guillaume Koch, Afshin Gangi

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 10/2016

Einloggen, um Zugang zu erhalten

Abstract

Objectives

The purpose of this study is to discuss technical aspects and rationales of magnetic resonance (MR)-guided cryoablation (CA) of Morton’s neuroma (MN); preliminary clinical experience is also retrospectively reviewed.

Methods

Procedures were performed under local anaesthesia on an outpatient basis. Lesion size and location, procedural (technical success, procedural time, complications) and clinical outcomes (patient satisfaction according to a four-point scale, residual pain according to a 0–10 visual analogue scale and instances of “stump neuroma”) were assessed via chart review and cross-sectional telephone survey after the 20th case.

Results

Twenty patients (15 female, 5 male; mean age 50.3 years) were included; 24 MN (mean size 12.7 mm) were treated. Technical success was 100 %. Mean procedural time was 40.9 ± 10.4 min (range 35–60). One minor complication (superficial cellulitis) was reported (4.2 %). Follow-up (mean 19.7 months) was available for 18/24 MN. Patient satisfaction on a per-lesion basis was as follows: “completely satisfied” in 77.7 %, “satisfied with minor reservations” in 16.6 % and “satisfied with major reservations” in 5.7 % of cases. Mean pain score at last follow-up post-CA was 3.0. No instances of “stump neuroma” were reported.

Conclusions

MR-guided CA of MN is a novel therapy which appears technically feasible. Clinical advantages of the procedure are high patient satisfaction, reduced risk of “stump neuroma” syndrome and good patient tolerance on an outpatient basis. Further, prospective studies are needed to confirm these encouraging results.
Literatur
1.
Zurück zum Zitat Morton TG. A peculiar and painful affection of the fourth metatarsophalangeal articulation. Am J Med Sci. 1876;71(141):37–45.CrossRef Morton TG. A peculiar and painful affection of the fourth metatarsophalangeal articulation. Am J Med Sci. 1876;71(141):37–45.CrossRef
2.
Zurück zum Zitat Lee MJ, Kim S, Huh YM, Song HT, Lee SA, Lee JW, Suh JS. Morton neuroma: evaluated with ultrasonography and MR imaging. Korean J Radiol. 2007;8(2):148–55.CrossRefPubMedPubMedCentral Lee MJ, Kim S, Huh YM, Song HT, Lee SA, Lee JW, Suh JS. Morton neuroma: evaluated with ultrasonography and MR imaging. Korean J Radiol. 2007;8(2):148–55.CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Morscher E, Ulrich J, Dick W. Morton’s interdigital neuroma: morphology and histological substrate. Foot Ankle Int. 2000;21:558–62.PubMed Morscher E, Ulrich J, Dick W. Morton’s interdigital neuroma: morphology and histological substrate. Foot Ankle Int. 2000;21:558–62.PubMed
4.
Zurück zum Zitat Hassouna H, Singh D. Morton’s metatarsalgia: pathogenesis, aetiology and current management. Acta Orthop Belg. 2005;71(6):646–55.PubMed Hassouna H, Singh D. Morton’s metatarsalgia: pathogenesis, aetiology and current management. Acta Orthop Belg. 2005;71(6):646–55.PubMed
5.
Zurück zum Zitat Thomson CE, Gibson JN, Martin D. Interventions for the treatment of Morton’s neuroma. Cochrane Database Syst Rev. 2004;3(3):1–14. Thomson CE, Gibson JN, Martin D. Interventions for the treatment of Morton’s neuroma. Cochrane Database Syst Rev. 2004;3(3):1–14.
6.
Zurück zum Zitat Thomson CE, Beggs I, Martin DJ, McMillan D, Edwards RT, Russell D, Yeo ST, Russell IT, Gibson JN. Methylprednisolone injections for the treatment of Morton neuroma. J Bone Jt Surg Am. 2013;95:790–8.CrossRef Thomson CE, Beggs I, Martin DJ, McMillan D, Edwards RT, Russell D, Yeo ST, Russell IT, Gibson JN. Methylprednisolone injections for the treatment of Morton neuroma. J Bone Jt Surg Am. 2013;95:790–8.CrossRef
7.
8.
Zurück zum Zitat Kundert HP, Plaass C, Stukenborg-Colsman C, Waizy H. Excision of Morton’s neuroma using a longitudinal plantar approach: a midterm follow-up study. Foot Ankle Spec. 2015;. doi:10.1177/1938640015599032.PubMed Kundert HP, Plaass C, Stukenborg-Colsman C, Waizy H. Excision of Morton’s neuroma using a longitudinal plantar approach: a midterm follow-up study. Foot Ankle Spec. 2015;. doi:10.​1177/​1938640015599032​.PubMed
9.
Zurück zum Zitat Bauer T, Gaumetou E, Klouche S, Hardy P, Maffulli N. Metatarsalgia and Morton’s disease: comparison of outcomes between open procedure and neurectomy versus percutaneous metatarsal osteotomies and ligament release with a minimum of 2 years of follow-up. J Foot Ankle Surg. 2015;54(3):373–7.CrossRefPubMed Bauer T, Gaumetou E, Klouche S, Hardy P, Maffulli N. Metatarsalgia and Morton’s disease: comparison of outcomes between open procedure and neurectomy versus percutaneous metatarsal osteotomies and ligament release with a minimum of 2 years of follow-up. J Foot Ankle Surg. 2015;54(3):373–7.CrossRefPubMed
10.
Zurück zum Zitat Bennett GL, Graham CE, Mauldin DM. Morton’s interdigital neuroma: a comprehensive treatment protocol. Foot Ankle Int. 1995;16:760–3.CrossRefPubMed Bennett GL, Graham CE, Mauldin DM. Morton’s interdigital neuroma: a comprehensive treatment protocol. Foot Ankle Int. 1995;16:760–3.CrossRefPubMed
11.
Zurück zum Zitat Pasquali C, Vulcano E, Novario R, Varotto D, Montoli C, Volpe A. Ultrasound-guided alcohol injection for Morton’s neuroma. Foot Ankle Int. 2015;36(1):55–9.CrossRefPubMed Pasquali C, Vulcano E, Novario R, Varotto D, Montoli C, Volpe A. Ultrasound-guided alcohol injection for Morton’s neuroma. Foot Ankle Int. 2015;36(1):55–9.CrossRefPubMed
12.
Zurück zum Zitat Gurdezi S, White T, Ramesh P. Alcohol injection for Morton’s neuroma: a five-year follow-up. Foot Ankle Int. 2013;34(8):1064–7.CrossRefPubMed Gurdezi S, White T, Ramesh P. Alcohol injection for Morton’s neuroma: a five-year follow-up. Foot Ankle Int. 2013;34(8):1064–7.CrossRefPubMed
13.
Zurück zum Zitat Chuter GS, Chua YP, Connell DA, Blackney MC. Ultrasound-guided radiofrequency ablation in the management of interdigital (Morton’s) neuroma. Skelet Radiol. 2013;42(1):107–11.CrossRef Chuter GS, Chua YP, Connell DA, Blackney MC. Ultrasound-guided radiofrequency ablation in the management of interdigital (Morton’s) neuroma. Skelet Radiol. 2013;42(1):107–11.CrossRef
14.
Zurück zum Zitat Deniz S, Purtuloglu T, Tekindur S, Cansız KH, Yetim M, Kılıckaya O, Senkal S, Bilgic S, Atim A, Kurt E. Ultrasound-guided pulsed radio frequency treatment in Morton’s neuroma. J Am Podiatr Med Assoc. 2015;105(4):302–6.CrossRefPubMed Deniz S, Purtuloglu T, Tekindur S, Cansız KH, Yetim M, Kılıckaya O, Senkal S, Bilgic S, Atim A, Kurt E. Ultrasound-guided pulsed radio frequency treatment in Morton’s neuroma. J Am Podiatr Med Assoc. 2015;105(4):302–6.CrossRefPubMed
15.
Zurück zum Zitat Friedman T, Richman D, Adler R. Sonographically guided cryoneurolysis: preliminary experience and clinical outcomes. J Ultrasound Med. 2012;31(12):2025–34.PubMed Friedman T, Richman D, Adler R. Sonographically guided cryoneurolysis: preliminary experience and clinical outcomes. J Ultrasound Med. 2012;31(12):2025–34.PubMed
16.
Zurück zum Zitat Hodor L, Barkal K, Hatch-Fox LD. Cryogenic denervation of the intermetatarsal space neuroma. J Foot Ankle Surg. 1997;36:311–4.CrossRefPubMed Hodor L, Barkal K, Hatch-Fox LD. Cryogenic denervation of the intermetatarsal space neuroma. J Foot Ankle Surg. 1997;36:311–4.CrossRefPubMed
17.
Zurück zum Zitat Caporusso EF, Fallat LM, Savoy-Moore R. Cryogenic neuroablation for the treatment of lower extremity neuromas. J Foot Ankle Surg. 2002;41:286–90.CrossRefPubMed Caporusso EF, Fallat LM, Savoy-Moore R. Cryogenic neuroablation for the treatment of lower extremity neuromas. J Foot Ankle Surg. 2002;41:286–90.CrossRefPubMed
18.
Zurück zum Zitat Cazzato RL, de Lara CT, Buy X, Ferron S, Hurtevent G, Fournier M, Debled M, Palussière J. Single-centre experience with percutaneous cryoablation of breast cancer in 23 consecutive non-surgical patients. Cardiovasc Interv Radiol. 2015;38(5):1237–43.CrossRef Cazzato RL, de Lara CT, Buy X, Ferron S, Hurtevent G, Fournier M, Debled M, Palussière J. Single-centre experience with percutaneous cryoablation of breast cancer in 23 consecutive non-surgical patients. Cardiovasc Interv Radiol. 2015;38(5):1237–43.CrossRef
19.
Zurück zum Zitat Littrup PJ, Bang HJ, Currier BP, Goodrich DJ, Aoun HD, Heilbrun LK, Adam BA. Soft-tissue cryoablation in diffuse locations: feasibility and intermediate term outcomes. J Vasc Interv Radiol. 2013;24(12):1817–25.CrossRefPubMedPubMedCentral Littrup PJ, Bang HJ, Currier BP, Goodrich DJ, Aoun HD, Heilbrun LK, Adam BA. Soft-tissue cryoablation in diffuse locations: feasibility and intermediate term outcomes. J Vasc Interv Radiol. 2013;24(12):1817–25.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Thompson SM, Callstrom MR, McKusick MA, Woodrum DA. Initial results of image-guided percutaneous ablation as second-line treatment for symptomatic vascular anomalies. Cardiovasc Interv Radiol. 2015;38(5):1171–8.CrossRef Thompson SM, Callstrom MR, McKusick MA, Woodrum DA. Initial results of image-guided percutaneous ablation as second-line treatment for symptomatic vascular anomalies. Cardiovasc Interv Radiol. 2015;38(5):1171–8.CrossRef
21.
Zurück zum Zitat Hsu M, Stevenson FF. Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies. Muscle Nerve. 2015;51(2):268–75.CrossRefPubMed Hsu M, Stevenson FF. Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies. Muscle Nerve. 2015;51(2):268–75.CrossRefPubMed
22.
Zurück zum Zitat Garnon J, Schlier A, Buy X, Tsoumakidou G, de Mathelin M, Breton E, Gangi A. Evaluation of percutaneous biopsies of renal masses under MRI-guidance: a retrospective study about 26 cases. Eur Radiol. 2015;25(3):617–23.CrossRefPubMed Garnon J, Schlier A, Buy X, Tsoumakidou G, de Mathelin M, Breton E, Gangi A. Evaluation of percutaneous biopsies of renal masses under MRI-guidance: a retrospective study about 26 cases. Eur Radiol. 2015;25(3):617–23.CrossRefPubMed
23.
Zurück zum Zitat Kerimaa P, Väänänen M, Ojala R, Hyvönen P, Lehenkari P, Tervonen O, Blanco Sequeiros RM. MRI-guidance in percutaneous core decompression of osteonecrosis of the femoral head. Eur Radiol. 2016;26(4):1180–5.CrossRefPubMed Kerimaa P, Väänänen M, Ojala R, Hyvönen P, Lehenkari P, Tervonen O, Blanco Sequeiros RM. MRI-guidance in percutaneous core decompression of osteonecrosis of the femoral head. Eur Radiol. 2016;26(4):1180–5.CrossRefPubMed
24.
Zurück zum Zitat Schouten MG, Hoeks CM, Bomers JG, Hulsbergen-van de Kaa CA, Witjes JA, Thompson LC, Rovers MM, Barentsz JO, Fütterer JJ. Location of prostate cancers determined by multiparametric and MRI-guided biopsy in patients with elevated prostate-specific antigen level and at least one negative transrectal ultrasound-guided biopsy. Am J Roentgenol. 2015;205(1):57–63.CrossRef Schouten MG, Hoeks CM, Bomers JG, Hulsbergen-van de Kaa CA, Witjes JA, Thompson LC, Rovers MM, Barentsz JO, Fütterer JJ. Location of prostate cancers determined by multiparametric and MRI-guided biopsy in patients with elevated prostate-specific antigen level and at least one negative transrectal ultrasound-guided biopsy. Am J Roentgenol. 2015;205(1):57–63.CrossRef
25.
Zurück zum Zitat Patel IJ, Davidson JC, Nikolic B, Salazar GM, Schwartzberg MS, Walker TG, Saad WA, Standards of Practice Committee, with Cardiovascular and Interventional Radiological Society of Europe (CIRSE) Endorsement. Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image-guided interventions. J Vasc Interv Radiol. 2012;23(6):727–36.CrossRefPubMed Patel IJ, Davidson JC, Nikolic B, Salazar GM, Schwartzberg MS, Walker TG, Saad WA, Standards of Practice Committee, with Cardiovascular and Interventional Radiological Society of Europe (CIRSE) Endorsement. Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image-guided interventions. J Vasc Interv Radiol. 2012;23(6):727–36.CrossRefPubMed
26.
Zurück zum Zitat Sunderland S. Nerve and nerve injuries. 2nd ed. New York: Churchill Livingstone; 1978. Sunderland S. Nerve and nerve injuries. 2nd ed. New York: Churchill Livingstone; 1978.
27.
Zurück zum Zitat Sacks D, McClenny TE, Cardella JF, Lewis CA. Society of Interventional Radiology clinical practice guidelines. J Vasc Interv Radiol. 2003;14:S199–202.CrossRefPubMed Sacks D, McClenny TE, Cardella JF, Lewis CA. Society of Interventional Radiology clinical practice guidelines. J Vasc Interv Radiol. 2003;14:S199–202.CrossRefPubMed
29.
Zurück zum Zitat Coughlin MJ, Pinsonneault T. Operative treatment of interdigital neuroma. A long-term follow-up study. J Bone Jt Surg Am. 2001;83:1321–8. Coughlin MJ, Pinsonneault T. Operative treatment of interdigital neuroma. A long-term follow-up study. J Bone Jt Surg Am. 2001;83:1321–8.
30.
Zurück zum Zitat Pace A, Scammell B, Dhar S. The outcome of Morton’s neurectomy in the treatment of metatarsalgia. Int Orthop. 2010;34(4):511–5.CrossRefPubMed Pace A, Scammell B, Dhar S. The outcome of Morton’s neurectomy in the treatment of metatarsalgia. Int Orthop. 2010;34(4):511–5.CrossRefPubMed
31.
Zurück zum Zitat Giannini S, Bacchini P, Ceccarelli F, Vannini F. Interdigital neuroma: clinical examination and histopathologic results in 63 cases treated with excision. Foot Ankle Int. 2004;25:79–84.PubMed Giannini S, Bacchini P, Ceccarelli F, Vannini F. Interdigital neuroma: clinical examination and histopathologic results in 63 cases treated with excision. Foot Ankle Int. 2004;25:79–84.PubMed
32.
Zurück zum Zitat Kitaoka HB, Alexander IJ, Adelaar RS, Nunley JA, Myerson MS, Sanders M. Clinical rating systems for the ankle-hindfoot, midfoot, hallux, and lesser toes. Foot Ankle Int. 1994;15:349–53.CrossRefPubMed Kitaoka HB, Alexander IJ, Adelaar RS, Nunley JA, Myerson MS, Sanders M. Clinical rating systems for the ankle-hindfoot, midfoot, hallux, and lesser toes. Foot Ankle Int. 1994;15:349–53.CrossRefPubMed
33.
Zurück zum Zitat Schreiber K, Khodaee M, Poddar S, Tweed EM. Clinical inquiry. What is the best way to treat Morton’s neuroma? J Fam Pract. 2011;60(3):157–8, 168. Schreiber K, Khodaee M, Poddar S, Tweed EM. Clinical inquiry. What is the best way to treat Morton’s neuroma? J Fam Pract. 2011;60(3):157–8, 168.
34.
Zurück zum Zitat Genon MP, Chin TY, Bedi HS, Blackney MC. Radio-frequency ablation for the treatment of Morton’s neuroma. ANZ J Surg. 2010;80(9):583–5.CrossRefPubMed Genon MP, Chin TY, Bedi HS, Blackney MC. Radio-frequency ablation for the treatment of Morton’s neuroma. ANZ J Surg. 2010;80(9):583–5.CrossRefPubMed
35.
Zurück zum Zitat Moore JL, Rosen R, Cohen J, Rosen B. Radiofrequency thermoneurolysis for the treatment of Morton’s neuroma. J Foot Ankle Surg. 2012;51:20–2.CrossRefPubMed Moore JL, Rosen R, Cohen J, Rosen B. Radiofrequency thermoneurolysis for the treatment of Morton’s neuroma. J Foot Ankle Surg. 2012;51:20–2.CrossRefPubMed
Metadaten
Titel
Percutaneous MR-Guided Cryoablation of Morton’s Neuroma: Rationale and Technical Details After the First 20 Patients
verfasst von
Roberto Luigi Cazzato
Julien Garnon
Nitin Ramamurthy
Georgia Tsoumakidou
Jean Caudrelier
Marie-Aude Thenint
Pramod Rao
Guillaume Koch
Afshin Gangi
Publikationsdatum
17.05.2016
Verlag
Springer US
Erschienen in
CardioVascular and Interventional Radiology / Ausgabe 10/2016
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-016-1365-7

Weitere Artikel der Ausgabe 10/2016

CardioVascular and Interventional Radiology 10/2016 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.