Skip to main content
main-content

05.08.2019 | Original Article | Ausgabe 2/2020 Open Access

Virchows Archiv 2/2020

Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research

Zeitschrift:
Virchows Archiv > Ausgabe 2/2020
Autoren:
Tiina Vesterinen, Kaisa Salmenkivi, Harri Mustonen, Teijo Kuopio, Elisa Lappi-Blanco, Timo Paavonen, Paula Vainio, Aija Knuuttila, Olli Carpén, Caj Haglund, Johanna Arola
Wichtige Hinweise
Caj Haglund and Johanna Arola are equal last authorship.
This article is part of the Topical Collection on Quality in Pathology

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Finnish hospital-integrated biobanks administer millions of formalin-fixed paraffin-embedded tissue samples collected within the clinical diagnostics. According to the Finnish Biobank Act, these samples can be coupled with patients’ clinical follow-up data and the data retrieved from national health registries. We collected a nationwide pulmonary carcinoid tumour series from Finnish biobanks to study prognostic factors as well as to explore how the number of tumours found in the Finnish biobanks corresponds to the number of tumours registered by the Finnish Cancer Registry (FCR). Finnish biobanks identified 88% of the tumours registered by the FCR and were able to deliver 63%. The main reasons for lacking samples were paucity of resected primary tumour tissue, incompatible primary diagnosis, and the absence of tissue blocks in the archives. The main bottleneck in the sample application process was retrieving patient data. Altogether, we received 224 tumour samples with appropriate patient data and identified six prognostic factors for shorter disease-specific survival: age over 56 years at the time of diagnosis, tumour size over 2.5 cm, atypical histology, Ki-67 proliferation index higher than 2.5%, hilar/mediastinal lymph node involvement at the time of diagnosis, and the presence of metastatic disease. In conclusion, the Finnish biobank infrastructure offers excellent opportunities for tissue-based research. However, to be able to develop the biobank operations further, involving more medical knowledge in the sample and data acquisition process is a necessity. Also, when working with tissue samples collected over decades, histological expertise is essential for re-evaluation and re-classification of the samples.

Unsere Produktempfehlungen

e.Med Interdisziplinär

Kombi-Abonnement

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 2/2020

Virchows Archiv 2/2020 Zur Ausgabe

Neu im Fachgebiet Pathologie

06.04.2020 | Schwerpunkt: Unser Immunsystem – der Staat im Staate | Ausgabe 3/2020

Der Darm im Fokus des Immunsystems

Seltene Darmerkrankungen bei primären Immundefekten

05.04.2020 | Adipositas | Schwerpunkt: Unser Immunsystem - der Staat im Staate | Ausgabe 3/2020

Fettgewebe und Malignität: Wie Adipositas Krankheiten begünstigt

02.04.2020 | Mammakarzinom | Schwerpunkt: Unser Immunsystem - der Staat im Staate | Ausgabe 3/2020

Immuntherapien beim Mammakarzinom: Neue Strategien

02.04.2020 | Schwerpunkt: Unser Immunsystem – der Staat im Staate | Ausgabe 3/2020

Das Komplementsystem – ein „hot topic“ nicht nur bei Nierenerkrankungen