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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

Performance of “VIKIA Malaria Ag Pf/Pan” (IMACCESS®), a new malaria rapid diagnostic test for detection of symptomatic malaria infections

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Monidarin Chou, Saorin Kim, Nimol Khim, Sophy Chy, Sarorn Sum, Dany Dourng, Lydie Canier, Chea Nguon, Didier Ménard
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2875-11-295) contains supplementary material, which is available to authorized users.
Monidarin Chou, Saorin Kim contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

MC, SK and DM contributed to the design and coordination of the study, assisted with data entry and interpretation and prepared the manuscript. SK supervised the field study. NK, SC, SS, DD and LC were involved in laboratory work. MC, SK, CN and DM helped to write the manuscript and gave constructive advice. All authors read and approved the final manuscript.

Abstract

Background

Recently, IMACCESS® developed a new malaria test (VIKIA Malaria Ag Pf/Pan™), based on the detection of falciparum malaria (HRP-2) and non-falciparum malaria (aldolase).

Methods

The performance of this new malaria rapid diagnostic test (RDT) was assessed using 1,000 febrile patients seeking malaria treatment in four health centres in Cambodia from August to December 2011. The results of the VIKIA Malaria Ag Pf/Pan were compared with those obtained by microscopy, the CareStart Malaria™ RDT (AccessBio®) which is currently used in Cambodia, and real-time PCR (as “gold standard”).

Results

The best performances of the VIKIA Malaria Ag Pf/Pan™ test for detection of both Plasmodium falciparum and non-P. falciparum were with 20–30 min reading times (sensitivity of 93.4% for P. falciparum and 82.8% for non-P. falciparum and specificity of 98.6% for P. falciparum and 98.9% for non-P. falciparum) and were similar to those for the CareStart Malaria™ test.

Conclusions

This new RDT performs similarly well as other commercially available tests (especially the CareStart Malaria™ test, used as comparator), and conforms to the World Health Organization’s recommendations for RDT performance. It is a good alternative tool for the diagnosis of malaria in endemic areas.
Zusatzmaterial
Authors’ original file for figure 1
12936_2012_2429_MOESM1_ESM.pdf
Authors’ original file for figure 2
12936_2012_2429_MOESM2_ESM.pdf
Authors’ original file for figure 3
12936_2012_2429_MOESM3_ESM.pdf
Authors’ original file for figure 4
12936_2012_2429_MOESM4_ESM.pdf
Authors’ original file for figure 5
12936_2012_2429_MOESM5_ESM.pdf
Literatur
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