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European Archives of Oto-Rhino-Laryngology

Erschienen in:

02.01.2019 | Head & Neck

Performance of whole-body ¹⁸F-FDG PET/CT as a posttreatment surveillance tool for sinonasal malignancies

verfasst von: Kerem Ozturk, Mehmet Gencturk, Emiro Caicedo-Granados, Faqian Li, Zuzan Cayci

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 3/2019

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Abstract

Purpose

To determine the diagnostic utility of posttreatment surveillance whole-body ¹⁸F-FDG PET/CT in detecting local tumor recurrence (R), regional lymph-node metastasis (LM), and distant metastasis (DM) in asymptomatic sinonasal cancer patients.

Methods

Eighty consecutive patients (53 men, 27 women; mean age, 60 years; range, 28–92 years) who had undergone 197 posttreatment whole-body ¹⁸F-FDG PET/CT examinations for sinonasal malignancies between January 2009 and August 2017 were retrospectively reviewed. ¹⁸F-FDG PET/CT findings were categorized as positive or negative for R, LM, and DM, separately. Outcomes of ¹⁸F-FDG PET/CT scans were compared with the final diagnosis confirmed by histological analysis or follow-up period for a minimum 12 months. The diagnostic accuracy of scans was calculated for each site using contingency tables. Impact on the management of ¹⁸F-FDG PET/CT examinations was additionally evaluated.

Results

¹⁸F-FDG PET/CT scans identified 37/44 of local recurrences, 21/23 of LMs, and 30/37 of DMs. For local recurrence, sensitivity, specificity, positive predictive value, and negative predictive value were 84% (68–97%), 95% (80–100%), 84% (68–97%), and 95% (80–100%), respectively. For LM, the respective values were 91% (75–100%), 99% (83–100%), 91% (75–100%), and 99% (83–100%). For DM, the values were 81% (64–97%), 99% (85–100%), 97% (81–100%), and 96% (81–100%), respectively. ¹⁸F-FDG PET/CT accounted for a change in management of 85% patients with recurrences.

Conclusions

Whole-body ¹⁸F-FDG PET/CT is a suitable surveillance tool for sinonasal malignancies in detecting locoregional and distant recurrences in asymptomatic patients without any evidence of recurrence on regular follow-up and endoscopy during the posttreatment period.

Khademi B, Moradi A, Hoseini S et al (2009) Malignant neoplasms of the sinonasal tract: report of 71 patients and literature review and analysis. J Oral Maxillofac Surg 13:191–199CrossRef

Kuijpens JHL, Louwman MW, Peters R et al (2012) Trends in sinonasal cancer in The Netherlands: more squamous cell cancer, less adenocarcinoma: a population-based study 1973–2009. Eur J Cancer 48:2369–2374CrossRefPubMed

Guntinas-Lichius O, Kreppel M, Stuetzer H et al (2007) Single modality and multimodality treatment of nasal and paranasal sinuses cancer: a single institution experience of 229 patients. Eur J Surg Oncol 33:222–228CrossRefPubMed

Llorente JL, López F, Suárez C et al (2014) Sinonasal carcinoma: clinical, pathological, genetic and therapeutic advances. Nat Rev Clin Oncol 11:460–472CrossRefPubMed

Gal TJ, Silver N, Huang B (2011) Demographics and treatment trends in sinonasal mucosal melanoma. Laryngoscope 121:2026–2033PubMed

Turner JH, Reh DD (2012) Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck 34:877–885CrossRefPubMed

Hanna E, DeMonte F, Ibrahim S et al (2009) Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results. Arch Otolaryngol Head Neck Surg 135:1219–1224CrossRefPubMed

Robbins KT, Ferlito A, Silver CE et al (2011) Contemporary management of sinonasal cancer. Head Neck 33:1352–1365CrossRefPubMed

Marcus C, Ciarallo A, Tahari AK et al (2014) Head and neck PET/CT: therapy response interpretation criteria (Hopkins criteria)—interreader reliability, accuracy, and survival outcomes. J Nucl Med 55:1411–1416CrossRefPubMedPubMedCentral

10.

Xu G-Z, Guan D-J, He Z-Y (2011) ¹⁸FDG-PET/CT for detecting distant metastases and second primary cancers in patients with head and neck cancer. A meta-analysis. Oral Oncol 47:560–565CrossRefPubMed

11.

Paidpally V, Chirindel A, Lam S et al (2012) FDG-PET/CT imaging biomarkers in head and neck squamous cell carcinoma. Imaging Med 4:633–647CrossRefPubMedPubMedCentral

12.

Subramaniam R, Truong M, Peller P et al (2010) Fluorodeoxyglucose–positron-emission tomography imaging of head and neck squamous cell cancer. AJNR Am J Neuroradiol 31:598–604CrossRefPubMed

13.

Kim G, Kim YS, Han EJ et al (2011) FDG-PET/CT as prognostic factor and surveillance tool for postoperative radiation recurrence in locally advanced head and neck cancer. Radiat Oncol 29:243CrossRef

14.

Purohit BS, Ailianou A, Dulguerov N et al (2014) FDG-PET/CT pitfalls in oncological head and neck imaging. Insights Imaging 5:585–602CrossRefPubMedPubMedCentral

15.

Gupta T, Master Z, Kannan S et al (2011) Diagnostic performance of post-treatment FDG PET or FDG PET/CT imaging in head and neck cancer: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging 38:2083–2095CrossRefPubMed

16.

Lamarre ED, Batra PS, Lorenz RR et al (2012) Role of positron emission tomography in management of sinonasal neoplasms—a single institution’s experience. Am J Otolaryngol 33:289–295CrossRefPubMed

17.

Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17:1471–1474CrossRefPubMed

18.

Tajudeen BA, Arshi A, Suh JD et al (2015) Esthesioneuroblastoma: an update on the UCLA experience, 2002–2013. J Neurol Surg B Skull Base 76:43–49CrossRefPubMed

19.

Maroldi R, Ravanelli M, Farina D et al (2015) Post-treatment evaluation of paranasal sinuses after treatment of sinonasal neoplasms. Neuroimaging Clin N Am 25:667–685CrossRefPubMed

20.

Digonnet A, Hamoir M, Andry G et al (2013) Post-therapeutic surveillance strategies in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol 270:1569–1580CrossRefPubMed

21.

Franchi A, Miligi L, Palomba A et al (2011) Sinonasal carcinomas: recent advances in molecular and phenotypic characterization and their clinical implications. Crit Rev Oncol Hematol 79:265–277CrossRefPubMed

22.

Mehanna H, Wong W-L, McConkey CC et al (2016) PET-CT surveillance versus neck dissection in advanced head and neck cancer. N Engl J Med 374:1444–1454CrossRefPubMed

23.

Ramakrishnan VR, Lee JY, O’Malley BW et al (2013) 18-FDG-PET in the initial staging of sinonasal malignancy. Laryngoscope 123:2962–2966CrossRefPubMed

24.

Gil Z, Even-Sapir E, Margalit N et al (2007) Integrated PET/CT system for staging and surveillance of skull base tumors. Head Neck 29:537–545CrossRefPubMed

25.

Wild D, Eyrich GK, Ciernik IF et al (2006) In-line (18)F-fluorodeoxyglucose positron emission tomography with computed tomography (PET/CT) in patients with carcinoma of the sinus/nasal area and orbit. J Craniomaxillofac Surg 34:9–16CrossRefPubMed

26.

Khalili S, Worrall DM, Brooks S et al (2016) Endoscopy versus imaging: analysis of surveillance methods in sinonasal malignancy. Head Neck 38:1229–1233CrossRefPubMed

27.

Workman AD, Glicksman JT, Parasher AK et al (2017) (18)FDG PET/CT in routine surveillance of asymptomatic patients following treatment of sinonasal neoplasms. Otolaryngol Head Neck Surg 157:1068–1074CrossRefPubMed

28.

Ozturk K, Gawande R, Gencturk M et al (2018) Imaging features of sinonasal tumors on positron emission tomography and magnetic resonance imaging including diffusion weighted imaging: a pictorial review. Clin Imaging 51:217–228CrossRefPubMed

29.

Kei PL, Vikram R, Yeung HW et al (2010) Incidental finding of focal FDG uptake in the bowel during PET/CT: CT features and correlation with histopathologic results. AJR Am J Roentgenol 194:W401–W406CrossRefPubMed

Titel: Performance of whole-body 18F-FDG PET/CT as a posttreatment surveillance tool for sinonasal malignancies
verfasst von: Kerem Ozturk
Mehmet Gencturk
Emiro Caicedo-Granados
Faqian Li
Zuzan Cayci
Publikationsdatum: 02.01.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 3/2019
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-05272-w

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Performance of whole-body ¹⁸F-FDG PET/CT as a posttreatment surveillance tool for sinonasal malignancies

Abstract

Purpose

Methods

Results

Conclusions

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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