Introduction
Materials and methods
Patients
Histomorphological evaluation and immunohistochemistry
Results
Clinical characteristics
Case | Age (years) | Sex | Clinical presentation | Other malignancies | Underlying malignancy (Immunoprofile) | Metastasis | Outcome | Follow up (month) | Treatment other than surgery |
---|---|---|---|---|---|---|---|---|---|
1 | 75 | M | Perianal erosive plaque | Chronic myeloid leukemia | None | N/A | Dieda | 60 | Radiation |
2 | 79 | F | Discomfort | Follicular lymphoma; breast carcinoma; urothelial carcinoma in-situ | None | N/A | Alive | 83 | None |
3 | 61 | M | Itching and irritation of the perianal area; erythema with whitish plaques | None | None | N/A | Alive | 31 | None |
4 | 86 | M | Perianal lesion | Basal cell carcinoma | None | N/A | Alive | 4 | |
5 | 81 | M | Discomfort | None | Mixed moderately differentiated adenocarcinoma with mucinous features and neuroendocrine (large cell) carcinoma (CK7+/CK20+/CDX2+) | Lymph nodes and liver | Dieda | 79 | None |
6 | 53 | F | Acute anal fissure, anal lesion | Basal cell carcinoma; breast carcinoma | Adenocarcinoma, well differentiated (CK7−/CK20+/CDX2+) | None | Alive | 61 | None |
7 | 86 | M | Discomfort | None | Adenocarcinoma, poorly differentiated (CK7+/CK20-) | None | Alive | 52 | None |
8 | 69 | F | None (detected during routine colon cancer screening biopsy) | None | Adenocarcinoma, moderately differentiated (CK7+/CK20+/CDX2+) | None | Alive | 16 | None |
9 | 83 | M | Perianal rash and lesion with ulceration | Basal cell carcinoma | Adenocarcinoma, moderately differentiated (CK7−/CK20+/CDX2+) | None | Alive | 7 | Chemoradiation |
10 | 69 | F | Anal/perianal rash and lesion | None | Adenocarcinoma with neuroendocrine and signet ring features (CK7+/CK20+/CDX2+) | None | Alive | 21 | None |
11 | 50 | M | Anal fistula | None | Adenocarcinoma with mucinous features | Lymph nodes | Alive | 227 | Chemotherapy |
12 | 70 | M | Perianal lesion | None | Mucinous adenocarcinoma (CK7+/CK20+/CDX2+) | Lymph nodes, liver and bone | Alive | 47 | Chemoradiation |
13 | 77 | M | None | None | Tubular adenoma with high-grade dysplasia (CK7−/CK20+/CDX2+) | None | Alive | 6 | None |
Pathologic findings
Immunohistochemical profile
Primary | Secondary | P value | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ||
Cytokeratin 7 | + | + | + | + | + | – | + | + (F) | – | + | ND | + | – | NS |
Cytokeratin 20 | – | – | + | + (F) | + | + | – | + | + | + | ND | + | + | NS |
CDX2 | – | – | ND | – | + | + | ND | + | + | + | ND | + | + | 0.008 |
MUC1 | + | + | ND | + | + | – | ND | – | ND | ND | ND | + | – | NS |
MUC2 | + | + | ND | + (F) | + | + | ND | + | ND | ND | ND | + | + | NS |
CEA | + | – | ND | + (F) | ND | + | + | + | ND | + | ND | ND | + | NS |
GCDFP-15 | + (F) | + | ND | + (F) | – | – | ND | – | ND | – | ND | – | – | 0.012 |
P40 | – | – | ND | – | – | – | ND | – | ND | ND | ND | ND | – | NS |
Mucicarmine | + | + | + | + | ND | + | + | + | ND | ND | ND | ND | + | NS |
GATA3 | + | + | ND | + | ND | – | ND | – | ND | ND | ND | – | + | NS |