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Translational Stroke Research

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01.04.2015 | Commentary

Perihematoma Edema: A Potential Translational Target in Intracerebral Hemorrhage?

verfasst von: Magdy Selim, Kevin N. Sheth

Erschienen in: Translational Stroke Research | Ausgabe 2/2015

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Excerpt

Secondary injury in intracerebral hemorrhage (ICH) is becoming increasingly well characterized and is the subject of intense investigations. After the initial injury caused by tissue disruption and mass effect of the hematoma, products of coagulation, clot retraction, and hemoglobin breakdown initiate a secondary cascade of deleterious events including apoptosis, necrosis, iron-mediated oxidative stress, inflammation, autophagy, and edema formation [1‐3]. Tissue swelling, in particular, may contribute to neurological deterioration and disability. …

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Titel: Perihematoma Edema: A Potential Translational Target in Intracerebral Hemorrhage?
verfasst von: Magdy Selim
Kevin N. Sheth
Publikationsdatum: 01.04.2015
Verlag: Springer US
Erschienen in: Translational Stroke Research / Ausgabe 2/2015
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-015-0389-7

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