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Journal of Cancer Research and Clinical Oncology

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19.09.2016 | Original Article – Cancer Research

Perilipin 1 is a highly specific marker for adipocytic differentiation in sarcomas with intermediate sensitivity

verfasst von: Christina C. Westhoff, Janice Mrozinski, Ina Riedel, Hans W. Heid, Roland Moll

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 2/2017

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Abstract

Purpose

Liposarcomas are the most common soft tissue sarcomas of adults. The identification of lipoblastic cells in soft tissue sarcomas is mandatory for the diagnosis of most subtypes of liposarcomas but may be difficult in conventional histology. The present study focuses on the expression and possible diagnostic impact of two PAT family proteins, perilipin 1/perilipin and perilipin 2/adipophilin in human liposarcomas.

Methods

Eighty-seven cases of liposarcomas and 30 cases of non-lipomatous sarcomas were investigated immunohistochemically for perilipin 1 and 2 using entire tissue sections. Statistical analyses were performed using appropriate tests.

Results

Most liposarcomas and non-lipomatous sarcomas displayed positivity for perilipin 2. In contrast, while more than two-thirds of liposarcomas presented perilipin 1 positivity, all non-lipomatous sarcomas studied were negative for this marker, with statistical significance (p < 0.001). Perilipin 1 expression increased with adipocytic differentiation of liposarcoma subtypes showing statistical significance (p < 0.001). Non-lipomatous sarcomas demonstrated variable expression levels of perilipin 2. The expression level of perilipin 2 appeared to be correlated with tumor cell degeneration, e.g., through hypoxia.

Conclusions

Perilipin 2 is not well suitable for distinction between liposarcomas and non-lipomatous sarcomas. However, perilipin 1 appeared to be a highly specific marker for liposarcoma and adipocytic differentiation in sarcomas with intermediate sensitivity.

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Titel: Perilipin 1 is a highly specific marker for adipocytic differentiation in sarcomas with intermediate sensitivity
verfasst von: Christina C. Westhoff
Janice Mrozinski
Ina Riedel
Hans W. Heid
Roland Moll
Publikationsdatum: 19.09.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 2/2017
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-016-2263-8

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Perilipin 1 is a highly specific marker for adipocytic differentiation in sarcomas with intermediate sensitivity

Abstract

Purpose

Methods

Results

Conclusions

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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