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Brain Structure and Function

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13.08.2020 | Original Article

Perinatal exposure to nicotine disrupts circadian locomotor and learning efficiency rhythms in juvenile mice

verfasst von: Martin A. Fuentes-Cano, Dulce J. Bustamante-Valdez, Pilar Durán

Erschienen in: Brain Structure and Function | Ausgabe 7/2020

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Abstract

The increased rates of nicotine exposure by electronic nicotine delivery systems (vaping), ingestion, or patches during pregnancy as an alternative to the smoking of tobacco arise concerns about the neurodevelopmental, cognitive, and behavioral long-term consequences in the juvenile offspring. Nowadays, the use of electronic cigarettes as supposed a safer smoking alternative has been increased mainly in young females at reproductive age, due to the “safety” misconception. However, previous studies suggest that exposure to nicotine during pregnancy and prenatal development may lead to detrimental effects in the postnatal lifespan. Nicotine, as an alkaloid, alters the reward system acting as acetylcholine (ACh) agonist on nicotinic cholinergic receptors (nAChRs). In early brain development, the cholinergic system is also involved in neurite outgrowth, cell survival, proliferation, differentiation, neurogenesis, and many other critical processes being considered as a developmental signal marker. The nicotine noxious effect at those early stages may impact the system programming and plasticity in the long-term postnatal life. In this study, we analyze the circadian locomotor activity and learning efficiency rhythms in the juvenile male offspring of mice exposed to nicotine through pregnancy and lactation. Attenuated rhythm amplitude and relative power of the circadian component were found in the nicotine exposed offspring (pN). The acrophase (the best performance during a 24-h cycle) of learning efficiency was delayed and the long-term memory consolidation task failed after 8 days of learning experience. The aforementioned results suggest nicotine exposure in uterus modifies the circadian modulation related to the memory consolidation and locomotor systems as well as its environmental temporal synchronization.

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Titel: Perinatal exposure to nicotine disrupts circadian locomotor and learning efficiency rhythms in juvenile mice
verfasst von: Martin A. Fuentes-Cano
Dulce J. Bustamante-Valdez
Pilar Durán
Publikationsdatum: 13.08.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 7/2020
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-020-02126-2

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Perinatal exposure to nicotine disrupts circadian locomotor and learning efficiency rhythms in juvenile mice

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