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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Dermatology 1/2015

Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial

Zeitschrift:
BMC Dermatology > Ausgabe 1/2015
Autoren:
Melanie Rae Simpson, Christian Kvikne Dotterud, Ola Storrø, Roar Johnsen, Torbjørn Øien
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12895-015-0030-1) contains supplementary material, which is available to authorized users.

Competing interests

T.Ø., O.S., C.K.D and M.R.S. participated in seminars sponsored by Tine BA. All other authors declare that they have no conflict of interest.

Authors’ contributions

OS, RJ and TØ designed the study and directed its implementation. MRS conducted the statistical analysis and drafted the manuscript. CKD contributed to the interpretation of results and writing of the manuscript. All authors were involved in the interpretation of the results, revision of draft manuscript and have approved the final manuscript.

Abstract

Background

Perinatal probiotics supplementation has been shown to be effective in the primary prevention of atopic dermatitis (AD) in early childhood, although the long term effects of probiotics on AD and other allergic diseases is less certain. We have previously reported a significant reduction in the cumulative incidence of AD at 2 years after maternal probiotic supplementation. In this study we present the effects of perinatal probiotics given to women from a general population on allergy related diseases in their offspring at 6 years.

Methods

Four hundred and fifteen pregnant women were randomised to receive probiotic or placebo milk in a double-blinded trial from 36 week gestation until 3 months postpartum. Probiotic milk contained Lactobacillus rhamnosos GG, L. acidophilus La-5 and Bifidobacterium animalis subsp. lactis Bb-12. At 6 years, children were re-assessed for AD, atopic sensitisation, asthma and allergic rhinoconjunctivitis (ARC).

Results

At 6 years, 81 and 82 children were assessed for AD in the probiotic and placebo groups, respectively. In a multiple imputation analysis, there was as trend towards a lower cumulative incidence of AD in the probiotic group compared to the placebo group (OR 0.64, 95 % CI 0.39-1.07, p = 0.086; NNT = 10). This finding was statistically significantly in the complete case analysis (OR 0.48, 95 % CI 0.25-0.92, p = 0.027, NNT = 6). The prevalence of asthma and atopic sensitisation, and the cumulative incidence of ARC were not significantly affected by the probiotic regime at 6 years of age.

Conclusions

Maternal probiotic ingestion alone may be sufficient for long term reduction in the cumulative incidence of AD, but not other allergy related diseases.

Trial registration

ClinicalTrials.gov identifier: NCT00159523
Zusatzmaterial
Additional file 1: Includes (a) Table S1. Definition of asthma and allergic rhinoconjunctivitis used at 2 and 6 years; (b) Table S2: Baseline data, characteristics and allergy related diseases at 2 years for those who did and did not submit 6 year child health questionnaire; (c) Details of multiple imputation model and (d) Details of pattern mixture model sensitivity analysis. (PDF 629 kb)
12895_2015_30_MOESM1_ESM.pdf
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