Skip to main content
Erschienen in: Current Allergy and Asthma Reports 6/2010

01.11.2010

Periodic Fever Syndromes

verfasst von: Zachary Jacobs, Christina E. Ciaccio

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 6/2010

Einloggen, um Zugang zu erhalten

Abstract

The periodic syndromes represent a heterogeneous group of disorders that can be very difficult for practicing physicians to diagnosis and treat. This article presents an orderly approach to hyperimmunoglobulin D syndrome; tumor necrosis factor receptor-1 periodic syndrome; familial Mediterranean fever; periodic fever with aphthous stomatitis, pharyngitis, and adenitis syndrome; and cryopyrin-associated periodic syndromes by highlighting the disease presentation, diagnosis, pathogenesis, and treatment. Recent advances are also discussed.
Literatur
1.
Zurück zum Zitat Drenth JP, Haagsma CJ, van der Meer JW: Hyperimmunoglobulinemia D and periodic fever syndrome. The clinical spectrum in a series of 50 patients. International Hyper-IgD Study Group. Medicine 1994, 73:133–144.CrossRefPubMed Drenth JP, Haagsma CJ, van der Meer JW: Hyperimmunoglobulinemia D and periodic fever syndrome. The clinical spectrum in a series of 50 patients. International Hyper-IgD Study Group. Medicine 1994, 73:133–144.CrossRefPubMed
2.
Zurück zum Zitat Drenth JP, Cuisset L, Grateau G, et al.: Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group. Nat Genet 1999, 22:178–181.CrossRefPubMed Drenth JP, Cuisset L, Grateau G, et al.: Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group. Nat Genet 1999, 22:178–181.CrossRefPubMed
3.
Zurück zum Zitat Houten SM, Frenkel J, Rijkers GT, et al.: Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome. Hum Mol Genet 2002, 11:3115–3124.CrossRefPubMed Houten SM, Frenkel J, Rijkers GT, et al.: Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome. Hum Mol Genet 2002, 11:3115–3124.CrossRefPubMed
4.
Zurück zum Zitat Haraldsson A, Weemaes CM, Jonasdottir S, et al.: Serum immunoglobulin D in infants and children. Scand J Immunol 2000, 51:415–418.CrossRefPubMed Haraldsson A, Weemaes CM, Jonasdottir S, et al.: Serum immunoglobulin D in infants and children. Scand J Immunol 2000, 51:415–418.CrossRefPubMed
5.
Zurück zum Zitat Mandey SH, Schneiders MS, Koster J, Waterham HR: Mutational spectrum and genotype-phenotype correlations in mevalonate kinase deficiency. Hum Mutat 2006, 27:796–802.CrossRefPubMed Mandey SH, Schneiders MS, Koster J, Waterham HR: Mutational spectrum and genotype-phenotype correlations in mevalonate kinase deficiency. Hum Mutat 2006, 27:796–802.CrossRefPubMed
6.
Zurück zum Zitat Simon A, Drewe E, van der Meer JW, et al.: Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. Clin Pharmacol Ther 2004, 75:476–483.CrossRefPubMed Simon A, Drewe E, van der Meer JW, et al.: Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. Clin Pharmacol Ther 2004, 75:476–483.CrossRefPubMed
7.
Zurück zum Zitat Attout H, Guez S, Ranaivo I, et al.: A patient with hyper-IgD syndrome responding to simvastatin treatment. Eur J Intern Med 2008, 19:e82–e83.CrossRefPubMed Attout H, Guez S, Ranaivo I, et al.: A patient with hyper-IgD syndrome responding to simvastatin treatment. Eur J Intern Med 2008, 19:e82–e83.CrossRefPubMed
8.
Zurück zum Zitat Arkwright PD, McDermott MF, Houten SM, et al.: Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept. Clin Exp Immunol 2002, 130:484–488.CrossRefPubMed Arkwright PD, McDermott MF, Houten SM, et al.: Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept. Clin Exp Immunol 2002, 130:484–488.CrossRefPubMed
9.
Zurück zum Zitat Rigante D, Ansuini V, Bertoni B, et al.: Treatment with anakinra in the hyperimmunoglobulinemia D/periodic fever syndrome. Rheumatol Int 2006, 27:97–100.CrossRefPubMed Rigante D, Ansuini V, Bertoni B, et al.: Treatment with anakinra in the hyperimmunoglobulinemia D/periodic fever syndrome. Rheumatol Int 2006, 27:97–100.CrossRefPubMed
10.
Zurück zum Zitat Naruto T, Nakagishi Y, Mori M, et al.: Hyper-IgD syndrome with novel mutation in a Japanese girl. Mod Rheumatol 2009, 19:96–99.CrossRefPubMed Naruto T, Nakagishi Y, Mori M, et al.: Hyper-IgD syndrome with novel mutation in a Japanese girl. Mod Rheumatol 2009, 19:96–99.CrossRefPubMed
11.
Zurück zum Zitat Sornsakrin M, Wenner K, Ganschow R: B cell cytopenia in two brothers with hyper-IgD and periodic fever syndrome. Eur J Pediatr 2009, 168:825–831.CrossRefPubMed Sornsakrin M, Wenner K, Ganschow R: B cell cytopenia in two brothers with hyper-IgD and periodic fever syndrome. Eur J Pediatr 2009, 168:825–831.CrossRefPubMed
12.
Zurück zum Zitat Hull KM, Drewe E, Aksentijevich I, et al.: The TNF receptor-associated periodic syndrome (TRAPS): emerging concepts of an autoinflammatory disorder. Medicine (Baltimore) 2002, 81:349–368.CrossRef Hull KM, Drewe E, Aksentijevich I, et al.: The TNF receptor-associated periodic syndrome (TRAPS): emerging concepts of an autoinflammatory disorder. Medicine (Baltimore) 2002, 81:349–368.CrossRef
13.
Zurück zum Zitat Mulley J, Saar K, Hewitt G, et al.: Gene localization for an autosomal dominant familial periodic fever to 12p13. Am J Hum Genet 1998, 62:884–889.CrossRefPubMed Mulley J, Saar K, Hewitt G, et al.: Gene localization for an autosomal dominant familial periodic fever to 12p13. Am J Hum Genet 1998, 62:884–889.CrossRefPubMed
14.
Zurück zum Zitat Nedjai B, Hitman GA, Yousaf N, et al.: Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 2008, 58:273–283.CrossRefPubMed Nedjai B, Hitman GA, Yousaf N, et al.: Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 2008, 58:273–283.CrossRefPubMed
15.
Zurück zum Zitat Stojanov S, Kastner DL: Familial autoinflammatory diseases: genetics, pathogenesis and treatment. Curr Opin Rheumatol 2005, 17:586–599.CrossRefPubMed Stojanov S, Kastner DL: Familial autoinflammatory diseases: genetics, pathogenesis and treatment. Curr Opin Rheumatol 2005, 17:586–599.CrossRefPubMed
16.
Zurück zum Zitat Drewe E, Huggins ML, Morgan AG, et al.: Treatment of renal amyloidosis with etanercept in tumour necrosis factor receptor-associated periodic syndrome. Rheumatology (Oxford) 2004, 43:1405–1408.CrossRef Drewe E, Huggins ML, Morgan AG, et al.: Treatment of renal amyloidosis with etanercept in tumour necrosis factor receptor-associated periodic syndrome. Rheumatology (Oxford) 2004, 43:1405–1408.CrossRef
17.
Zurück zum Zitat • Gattorno M, Pelagatti MA, Meini A, et al.: Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 2008, 58:1516–1520. In this paper, five patients with confirmed TRAPS were treated successfully with anakinra, showing a prompt response and resolution of symptoms. During the next several months, while treatment was continued, there were no episodes of fever or other clinical manifestations of the disease.CrossRefPubMed • Gattorno M, Pelagatti MA, Meini A, et al.: Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 2008, 58:1516–1520. In this paper, five patients with confirmed TRAPS were treated successfully with anakinra, showing a prompt response and resolution of symptoms. During the next several months, while treatment was continued, there were no episodes of fever or other clinical manifestations of the disease.CrossRefPubMed
18.
Zurück zum Zitat Nedjai B, Hitman GA, Quillinan N, et al.: Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 2009, 60:619–625.CrossRefPubMed Nedjai B, Hitman GA, Quillinan N, et al.: Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 2009, 60:619–625.CrossRefPubMed
19.
Zurück zum Zitat Ben-Chetrit E, Levy M: Familial Mediterranean fever. Lancet 1998, 351:659–664. Ben-Chetrit E, Levy M: Familial Mediterranean fever. Lancet 1998, 351:659–664.
20.
Zurück zum Zitat Tidow N, Chen X, Muller C, et al.: Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin. Blood 2000, 95:1451–1455.PubMed Tidow N, Chen X, Muller C, et al.: Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin. Blood 2000, 95:1451–1455.PubMed
21.
Zurück zum Zitat Samuels J, Aksentijevich I, Torosyan Y, et al.: Familial Mediterranean fever at the millennium. Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health. Medicine (Baltimore) 1998, 77:268–297.CrossRef Samuels J, Aksentijevich I, Torosyan Y, et al.: Familial Mediterranean fever at the millennium. Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health. Medicine (Baltimore) 1998, 77:268–297.CrossRef
22.
Zurück zum Zitat Yalcinkaya F, Ozen S, Ozcakar ZB, et al.: A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology (Oxford) 2009, 48:395–398.CrossRef Yalcinkaya F, Ozen S, Ozcakar ZB, et al.: A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology (Oxford) 2009, 48:395–398.CrossRef
23.
Zurück zum Zitat Ben-Chetrit E, Levy M: Colchicine prophylaxis in familial Mediterranean fever: reappraisal after 15 years. Semin Arthritis Rheum 1991, 20:241–246.CrossRefPubMed Ben-Chetrit E, Levy M: Colchicine prophylaxis in familial Mediterranean fever: reappraisal after 15 years. Semin Arthritis Rheum 1991, 20:241–246.CrossRefPubMed
24.
Zurück zum Zitat Lidar M, Scherrmann JM, Shinar Y, et al.: Colchicine nonresponsiveness in familial Mediterranean fever: clinical, genetic, pharmacokinetic, and socioeconomic characterization. Semin Arthritis Rheum 2004, 33:273–282.CrossRefPubMed Lidar M, Scherrmann JM, Shinar Y, et al.: Colchicine nonresponsiveness in familial Mediterranean fever: clinical, genetic, pharmacokinetic, and socioeconomic characterization. Semin Arthritis Rheum 2004, 33:273–282.CrossRefPubMed
25.
Zurück zum Zitat Tunca M, Akar S, Soyturk M, et al.: The effect of interferon alpha administration on acute attacks of familial Mediterranean fever: a double-blind, placebo-controlled trial. Clin Exp Rheumatol 2004, 22:S37–S40.PubMed Tunca M, Akar S, Soyturk M, et al.: The effect of interferon alpha administration on acute attacks of familial Mediterranean fever: a double-blind, placebo-controlled trial. Clin Exp Rheumatol 2004, 22:S37–S40.PubMed
26.
Zurück zum Zitat Calligaris L, Marchetti F, Tommasini A, Ventura A: The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever. Eur J Pediatr 2008, 167:695–696.CrossRefPubMed Calligaris L, Marchetti F, Tommasini A, Ventura A: The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever. Eur J Pediatr 2008, 167:695–696.CrossRefPubMed
27.
Zurück zum Zitat Moser C, Pohl G, Haslinger I, et al.: Successful treatment of familial Mediterranean fever with anakinra and outcome after renal transplantation. Nephrol Dial Transplant 2009, 24:676–678.CrossRefPubMed Moser C, Pohl G, Haslinger I, et al.: Successful treatment of familial Mediterranean fever with anakinra and outcome after renal transplantation. Nephrol Dial Transplant 2009, 24:676–678.CrossRefPubMed
28.
Zurück zum Zitat Padeh S, Brezniak N, Zemer D, et al.: Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. J Pediatr 1999, 135:98–101.CrossRefPubMed Padeh S, Brezniak N, Zemer D, et al.: Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. J Pediatr 1999, 135:98–101.CrossRefPubMed
29.
Zurück zum Zitat Thomas KT, Feder HM Jr, Lawton AR, et al.: Periodic fever syndrome in children. J Pediatr 1999, 135:15–21.CrossRefPubMed Thomas KT, Feder HM Jr, Lawton AR, et al.: Periodic fever syndrome in children. J Pediatr 1999, 135:15–21.CrossRefPubMed
30.
Zurück zum Zitat Dagan E, Gershoni-Baruch R, Khatib I, et al.: MEFV, TNF1rA, CARD15 and NLRP3 mutation analysis in PFAPA. Rheumatol Int 2010, 30:633–636.CrossRefPubMed Dagan E, Gershoni-Baruch R, Khatib I, et al.: MEFV, TNF1rA, CARD15 and NLRP3 mutation analysis in PFAPA. Rheumatol Int 2010, 30:633–636.CrossRefPubMed
31.
Zurück zum Zitat Stojanov S, Hoffmann F, Kery A, et al.: Cytokine profile in PFAPA syndrome suggests continuous inflammation and reduced anti-inflammatory response. Eur Cytokine Netw 2006, 17:90–97.PubMed Stojanov S, Hoffmann F, Kery A, et al.: Cytokine profile in PFAPA syndrome suggests continuous inflammation and reduced anti-inflammatory response. Eur Cytokine Netw 2006, 17:90–97.PubMed
33.
Zurück zum Zitat Gattorno M, Caorsi R, Meini A, et al.: Differentiating PFAPA syndrome from monogenic periodic fevers. Pediatrics 2009, 124:e721–e728.CrossRefPubMed Gattorno M, Caorsi R, Meini A, et al.: Differentiating PFAPA syndrome from monogenic periodic fevers. Pediatrics 2009, 124:e721–e728.CrossRefPubMed
34.
Zurück zum Zitat Tasher D, Somekh E, Dalal I: PFAPA syndrome: new clinical aspects disclosed. Arch Dis Child 2006, 91:981–984.CrossRefPubMed Tasher D, Somekh E, Dalal I: PFAPA syndrome: new clinical aspects disclosed. Arch Dis Child 2006, 91:981–984.CrossRefPubMed
35.
Zurück zum Zitat Pillet P, Ansoborlo S, Carrere A, et al.: (P)FAPA syndrome: value of cimetidine. Arch Pediatr 2000, 7:54–57.CrossRefPubMed Pillet P, Ansoborlo S, Carrere A, et al.: (P)FAPA syndrome: value of cimetidine. Arch Pediatr 2000, 7:54–57.CrossRefPubMed
36.
Zurück zum Zitat Garavello W, Romagnoli M, Gaini RM: Effectiveness of adenotonsillectomy in PFAPA syndrome: a randomized study. J Pediatr 2009, 155:250–253.CrossRefPubMed Garavello W, Romagnoli M, Gaini RM: Effectiveness of adenotonsillectomy in PFAPA syndrome: a randomized study. J Pediatr 2009, 155:250–253.CrossRefPubMed
37.
Zurück zum Zitat Padeh S, Stoffman N, Berkun Y: Periodic fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA syndrome) in adults. Isr Med Assoc J 2008, 10:358–360.PubMed Padeh S, Stoffman N, Berkun Y: Periodic fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA syndrome) in adults. Isr Med Assoc J 2008, 10:358–360.PubMed
38.
Zurück zum Zitat Neven B, Callebaut I, Prieur AM, et al.: Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU. Blood 2004, 103:2809–2815.CrossRefPubMed Neven B, Callebaut I, Prieur AM, et al.: Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU. Blood 2004, 103:2809–2815.CrossRefPubMed
39.
Zurück zum Zitat • Goldbach-Mansky R, Kastner DL: Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol 2009, 124:1141–1149. This is an exceptional review article that details the relationship between the inflammasome and IL-1.CrossRefPubMed • Goldbach-Mansky R, Kastner DL: Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol 2009, 124:1141–1149. This is an exceptional review article that details the relationship between the inflammasome and IL-1.CrossRefPubMed
40.
Zurück zum Zitat Hawkins PN, Lachmann HJ, Aganna E, McDermott MF: Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum 2004, 50:607–612.CrossRefPubMed Hawkins PN, Lachmann HJ, Aganna E, McDermott MF: Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum 2004, 50:607–612.CrossRefPubMed
41.
Zurück zum Zitat Drenth JP, van der Meer JW: The inflammasome—a linebacker of innate defense. N Engl J Med 2006, 355:730–732.CrossRefPubMed Drenth JP, van der Meer JW: The inflammasome—a linebacker of innate defense. N Engl J Med 2006, 355:730–732.CrossRefPubMed
42.
Zurück zum Zitat Aksentijevich I, D Putnam C, Remmers EF, et al.: The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model. Arthritis Rheum 2007, 56:1273–1285.CrossRefPubMed Aksentijevich I, D Putnam C, Remmers EF, et al.: The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model. Arthritis Rheum 2007, 56:1273–1285.CrossRefPubMed
43.
Zurück zum Zitat • Hoffman HM: Therapy of autoinflammatory syndromes. J Allergy Clin Immunol 2009, 124:1129–1138. This is an excellent article detailing the general approach to the treatment of autoinflammatory disorders, with a focus on newly approved therapies and novel approaches for the future.CrossRefPubMed • Hoffman HM: Therapy of autoinflammatory syndromes. J Allergy Clin Immunol 2009, 124:1129–1138. This is an excellent article detailing the general approach to the treatment of autoinflammatory disorders, with a focus on newly approved therapies and novel approaches for the future.CrossRefPubMed
44.
Zurück zum Zitat • Ross JB, Finlayson LA, Klotz PJ, et al.: Use of anakinra (Kineret) in the treatment of familial cold autoinflammatory syndrome with a 16-month follow-up. J Cutan Med Surg 2008, 12:8–16. The authors very clearly highlight the role of anakinra in patients with FCAS, with follow-up at 4 and 16 months.PubMed • Ross JB, Finlayson LA, Klotz PJ, et al.: Use of anakinra (Kineret) in the treatment of familial cold autoinflammatory syndrome with a 16-month follow-up. J Cutan Med Surg 2008, 12:8–16. The authors very clearly highlight the role of anakinra in patients with FCAS, with follow-up at 4 and 16 months.PubMed
45.
Zurück zum Zitat Hawkins PN, Lachmann HJ, McDermott MF: Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N Engl J Med 2003, 348:2583–2584.CrossRefPubMed Hawkins PN, Lachmann HJ, McDermott MF: Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N Engl J Med 2003, 348:2583–2584.CrossRefPubMed
46.
Zurück zum Zitat Mirault T, Launay D, Cuisset L, et al.: Recovery from deafness in a patient with Muckle-Wells syndrome treated with anakinra. Arthritis Rheum 2006, 54:1697–1700.CrossRefPubMed Mirault T, Launay D, Cuisset L, et al.: Recovery from deafness in a patient with Muckle-Wells syndrome treated with anakinra. Arthritis Rheum 2006, 54:1697–1700.CrossRefPubMed
47.
Zurück zum Zitat Goldbach-Mansky R, Dailey NJ, Canna SW, et al.: Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med 2006, 355:581–592.CrossRefPubMed Goldbach-Mansky R, Dailey NJ, Canna SW, et al.: Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med 2006, 355:581–592.CrossRefPubMed
48.
Zurück zum Zitat Hoffman HM, Throne ML, Amar NJ, et al.: Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum 2008, 58:2443–2452.CrossRefPubMed Hoffman HM, Throne ML, Amar NJ, et al.: Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum 2008, 58:2443–2452.CrossRefPubMed
49.
Zurück zum Zitat • Lachmann HJ, Kone-Paut I, Kuemmerle-Deschner JB, et al.: Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med 2009, 360:2416–2425. This paper demonstrated that treatment with subcutaneous canakinumab (an IL-1β monoclonal antibody) once every 8 weeks was associated with a rapid remission of symptoms in patients with CAPS.CrossRefPubMed • Lachmann HJ, Kone-Paut I, Kuemmerle-Deschner JB, et al.: Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med 2009, 360:2416–2425. This paper demonstrated that treatment with subcutaneous canakinumab (an IL-1β monoclonal antibody) once every 8 weeks was associated with a rapid remission of symptoms in patients with CAPS.CrossRefPubMed
50.
Zurück zum Zitat Meng G, Strober W: New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations. Eur J Immunol 2010, 40:649–653.CrossRefPubMed Meng G, Strober W: New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations. Eur J Immunol 2010, 40:649–653.CrossRefPubMed
Metadaten
Titel
Periodic Fever Syndromes
verfasst von
Zachary Jacobs
Christina E. Ciaccio
Publikationsdatum
01.11.2010
Verlag
Current Science Inc.
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 6/2010
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-010-0141-z

Weitere Artikel der Ausgabe 6/2010

Current Allergy and Asthma Reports 6/2010 Zur Ausgabe

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.