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Cancer Microenvironment
Erschienen in: Cancer Microenvironment 1/2019

30.03.2018 | Original Article

Peripheral Blood Cell Interactions of Cancer-Derived Exosomes Affect Immune Function

verfasst von: Heather R. Ferguson Bennit, Amber Gonda, James R. W. McMullen, Janviere Kabagwira, Nathan R. Wall

Erschienen in: Cancer Microenvironment | Ausgabe 1/2019

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Abstract

Cancer-derived exosomes are constitutively produced and secreted into the blood and biofluids of their host patients providing a liquid biopsy for early detection and diagnosis. Given their ubiquitous nature, cancer exosomes influence biological mechanisms that are beneficial to the tumor cells where they are produced and the microenvironment in which these tumors exist. Accumulating evidence suggests that exosomes transport proteins, lipids, DNA, mRNA, miRNA and long non coding RNA (lncRNA) for the purpose of cell-cell and cell-extracellular communication. These exosomes consistently reflect the status as well as identity of their cell of origin and as such may conceivably be affecting the ability of a functional immune system to recognize and eliminate cancer cells. Recognizing and mapping the pathways in which immune suppression is garnered through these tumor derived exosome (TEX) may lead to treatment strategies in which specific cell membrane proteins or receptors may be targeted, allowing for immune surveillance to once again help with the treatment of cancer. This Review focuses on how cancer exosomes interact with immune cells in the blood.
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Metadaten
Titel
Peripheral Blood Cell Interactions of Cancer-Derived Exosomes Affect Immune Function
verfasst von
Heather R. Ferguson Bennit
Amber Gonda
James R. W. McMullen
Janviere Kabagwira
Nathan R. Wall
Publikationsdatum
30.03.2018
Verlag
Springer Netherlands
Erschienen in
Cancer Microenvironment / Ausgabe 1/2019
Print ISSN: 1875-2292
Elektronische ISSN: 1875-2284
DOI
https://doi.org/10.1007/s12307-018-0209-1

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