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Erschienen in:
01.02.2009 | Experimental Study
Peripheral nerve regeneration: autologous conduit of vein plus perineurium
Erschienen in: European Journal of Plastic Surgery | Ausgabe 1/2009
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A new method to enhance peripheral nerve regeneration is described. A 2-cm-long segment of right sciatic nerve of 90 Sprague-Dawley rats was transected and the gap was then bridged using one of the three methods: group 1 (treated, n
1 = 30), a 2-cm-long strip of perineurium inserted inside a 2-cm-long vein graft; group 2 (control, n
2 = 30), a vein graft alone; group 3 (standard nerve graft, n
3 = 30), a resected segment of the sciatic nerve. Clinical and electrophysiological tests and quantitative analysis carried out 12 weeks after surgical procedure showed a good nerve regeneration for the treated and the control vein group, although it was lower than the standard nerve graft group. G factor values, index of nervous myelinization, were not significantly different between groups 1 and 3 (P < 0.05), but either were significantly lower than that of group 2.