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Metabolic Brain Disease

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06.12.2017 | Original Article

Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges

verfasst von: De Wet Wolmarans, Isabella M. Scheepers, Dan J. Stein, Brian H. Harvey

Erschienen in: Metabolic Brain Disease | Ausgabe 2/2018

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Abstract

Obsessive-compulsive disorder (OCD) is a prevalent and debilitating condition, characterized by intrusive thoughts and repetitive behavior. Animal models of OCD arguably have the potential to contribute to our understanding of the condition. Deer mice (Permomyscus maniculatus bairdii) are characterized by stereotypic behavior which is reminiscent of OCD symptomology, and which may serve as a naturalistic animal model of this disorder. Moreover, a range of deer mouse repetitive behaviors may be representative of different compulsive-like phenotypes. This paper will review work on deer mouse behavior, and evaluate the extent to which this serves as a valid and useful model of OCD. We argue that findings over the past decade indicate that the deer mouse model has face, construct and predictive validity.

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Titel: Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges
verfasst von: De Wet Wolmarans
Isabella M. Scheepers
Dan J. Stein
Brian H. Harvey
Publikationsdatum: 06.12.2017
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 2/2018
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-0161-7

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Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges

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