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01.12.2012 | Case report | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Persistent increase in alpha-fetoprotein level in a patient without underlying liver disease who underwent curative resection of hepatocellular carcinoma. A case report and review of the literature

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Isidoro Di Carlo, Maurizio Mannino, Adriana Toro, Annalisa Ardiri, Antonio Galia, Giovanni Cappello, Gaetano Bertino
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-79) contains supplementary material, which is available to authorized users.

Competing interests

All authors declare that they have no competing interests.

Authors’ contributions

IDC was the principle investigator who prepared, organized, and edited all aspects of the manuscript, and the surgeon who performed the operation. MM supported the work of the principle investigator in writing and editing the manuscript. AT supported the work of the principle investigator in writing and editing the manuscript. AA supported the work of the principle investigator in preparing the manuscript. AG was the pathologist who performed the pathological examination of the surgical specimen. GC supported the work of the principle investigator in preparing the manuscript. GB supported the work of the principle investigator in preparing the manuscript. All authors read and approved the final manuscript.

Abstract

Introduction

Alpha-fetoprotein (AFP) is an oncofetal protein produced by hepatocellular carcinoma (HCC). AFP level can also be elevated in other neoplastic or non-neoplastic conditions. An elevated AFP level has high diagnostic significance for HCC; at a level of >200 ng/mL, the probability of HCC is >90%. The aim of the present paper is to report a patient who underwent curative resection of HCC, who had a persistently elevated AFP level postoperatively but did not develop recurrence during a 2-year follow-up period. A review of the literature is also presented.

Case report

An 82-year-old male was referred following a computed tomography scan showing a 160 mm diameter mass in the left lobe of the liver. This huge mass was diagnosed as HCC, arising in the absence of cirrhosis or viral hepatitis. After tumor removal, the patient’s high AFP level persisted for 2 years.

Conclusion

As steatosis was the only pathological change in the remnant liver, this may have caused the persistently elevated AFP level in this patient.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_995_MOESM1_ESM.pdf
Authors’ original file for figure 2
12957_2012_995_MOESM2_ESM.pdf
Authors’ original file for figure 3
12957_2012_995_MOESM3_ESM.pdf
Authors’ original file for figure 4
12957_2012_995_MOESM4_ESM.pdf
Literatur
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