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Cancer Immunology, Immunotherapy

Erschienen in:

11.04.2018 | Focussed Research Review

Personalized cancer vaccines: adjuvants are important, too

verfasst von: Cécile Gouttefangeas, Hans-Georg Rammensee

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 12/2018

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Abstract

Therapeutic cancer vaccines have shown limited clinical efficacy so far. Nevertheless, in the meantime, our understanding of immune cell function and the interactions of immune cells with growing tumors has advanced considerably. We are now in a position to invest this knowledge into the design of more powerful vaccines and therapy combinations aimed at increasing immunogenicity and decreasing tumor-induced immunosuppression. This review focuses essentially on peptide-based human vaccines. We will discuss two aspects that are critical for increasing their intrinsic immunogenicity: the selection of the antigen(s) to be targeted, and the as yet unmet need for strong adjuvants.

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Titel: Personalized cancer vaccines: adjuvants are important, too
verfasst von: Cécile Gouttefangeas
Hans-Georg Rammensee
Publikationsdatum: 11.04.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 12/2018
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-018-2158-4

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