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Erschienen in: Current Neurology and Neuroscience Reports 11/2022

15.10.2022 | Neuro-Ophthalmology (V. Pelak, Section Editor)

Perspectives and a Systematic Scoping Review on Longitudinal Profiles of Posterior Cortical Atrophy Syndrome

verfasst von: Victoria S. Pelak, Asher Mahmood, Kathryn Abe-Ridgway

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 11/2022

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Abstract 

Purpose of Review

To provide perspectives on the importance of understanding longitudinal profiles of posterior cortical atrophy (PCA) and report results of a scoping review to identify data and knowledge gaps related to PCA survival and longitudinal clinical and biomarker outcomes.

Recent Findings

Thirteen longitudinal studies were identified; all but two had fewer than 30 participants with PCA. Relatively few longitudinal data exist, particularly for survival.

Summary

In PCA, posterior cortical dysfunction and atrophy progress at faster rates compared to non-posterior regions, potentially up to a decade after symptom onset. Unlike typical AD, PCA phenotype-defined cognitive dysfunction and atrophy remain relatively more severe compared to other regions throughout the PCA course. Select cognitive tests hold promise as PCA outcome measures and for staging. Further longitudinal investigations are critically needed to enable PCA inclusion in treatment trials and to provide appropriate care to patients and enhance our understanding of the pathophysiology of dementing diseases.
Literatur
5.
Zurück zum Zitat • Murray ME, Graff-Radford NR, Ross OA, Petersen RC, Duara R, Dickson DW. Neuropathologically defined subtypes of Alzheimer’s disease with distinct clinical characteristics: a retrospective study. Lancet Neurol. 2011;10(9):785–96. https://doi.org/10.1016/S1474-4422(11)70156-9. (A systematic study of AD brain bank tissue revealing clinicopathological subtypes that include hippocampal sparing, typical, and limbic predominant that accounted for approximately 25% of cases.)CrossRefPubMedPubMedCentral • Murray ME, Graff-Radford NR, Ross OA, Petersen RC, Duara R, Dickson DW. Neuropathologically defined subtypes of Alzheimer’s disease with distinct clinical characteristics: a retrospective study. Lancet Neurol. 2011;10(9):785–96. https://​doi.​org/​10.​1016/​S1474-4422(11)70156-9. (A systematic study of AD brain bank tissue revealing clinicopathological subtypes that include hippocampal sparing, typical, and limbic predominant that accounted for approximately 25% of cases.)CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Logsdon RG, Gibbons LE, McCurry SM, Teri L. Quality of life in Alzheimer’s disease: patient and caregiver reports. J Ment Health Aging. 1999;5(1):21–32. Logsdon RG, Gibbons LE, McCurry SM, Teri L. Quality of life in Alzheimer’s disease: patient and caregiver reports. J Ment Health Aging. 1999;5(1):21–32.
40.
Zurück zum Zitat Phillips JS, Nitchie FJ, Da Re F, et al. Rates of longitudinal change in (18) F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer’s disease. Alzheimers Dement. 2022;18(6):1235–47.CrossRefPubMed Phillips JS, Nitchie FJ, Da Re F, et al. Rates of longitudinal change in (18) F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer’s disease. Alzheimers Dement. 2022;18(6):1235–47.CrossRefPubMed
41.
Zurück zum Zitat • Sintini I, Graff-Radford J, Jones DT, et al. Tau and amyloid relationships with resting-state functional connectivity in atypical Alzheimer’s disease. Cereb Cortex. 2021;31(3):1693–706. https://doi.org/10.1093/cercor/bhaa319. (One of the few studies to investigate potential mechanisms of disease spread using longitudinal data.)CrossRefPubMed • Sintini I, Graff-Radford J, Jones DT, et al. Tau and amyloid relationships with resting-state functional connectivity in atypical Alzheimer’s disease. Cereb Cortex. 2021;31(3):1693–706. https://​doi.​org/​10.​1093/​cercor/​bhaa319. (One of the few studies to investigate potential mechanisms of disease spread using longitudinal data.)CrossRefPubMed
Metadaten
Titel
Perspectives and a Systematic Scoping Review on Longitudinal Profiles of Posterior Cortical Atrophy Syndrome
verfasst von
Victoria S. Pelak
Asher Mahmood
Kathryn Abe-Ridgway
Publikationsdatum
15.10.2022
Verlag
Springer US
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 11/2022
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-022-01238-y

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