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International Archives of Occupational and Environmental Health

Erschienen in:

07.08.2018 | Review

Perspectives on multisensory perception disruption in idiopathic environmental intolerance: a systematic review

verfasst von: Andrea Viziano, Alessandro Micarelli, Guido Pasquantonio, David Della-Morte, Marco Alessandrini

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 8/2018

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Abstract

Purpose

Multiple chemical sensitivity (MCS) also known as idiopathic environmental intolerance/illness (IEI) encompasses a cohort of subjective symptoms characterized by susceptibility to a wide spectrum of environmental compounds, causing symptoms involving various organs and a decrease in quality of life. The aim of this systematic review is to summarize evidence about MCS, with focus on indexed studies analyzing sensory pathway-related disorders.

Methods

Medical databases were searched for English language articles related to the topic, published between 1965 and 2017 in academic, peer-reviewed journals. Particular focus was concentrated on articles depicting disturbances involving sensory organs. References of the relevant articles were examined to identify additional significant documents.

Results

Fifty-eight studies were eligible for full text review. Of these, 34 studies met the selection criteria and were included in this analysis. Many variables, such as different diagnostic criteria, lack of homogeneous symptom questionnaires and the general incidence of personality traits in control subjects, biased studies as confounding factors. However, moderate evidences show that sensory pathways are somewhat altered, especially with respect to information processing in the limbic system and related cortical areas. Recent studies suggested the presence, in MCS cohorts, of attention bias, sensitization and limbic kindling, as well as recently revealed subclinical organic alterations along sensory pathways.

Conclusions

Evidences are consistent with MCS/IEI to be the result of a neural altered processing of sensorial ascending pathways, which combined with peculiar personality traits constitutes the underpinning of a multisensory condition needing multidisciplinary clinical approach.

Alessandrini M, D’Erme G, Bruno E, Napolitano B, Magrini A (2003) Vestibular compensation: analysis of postural re-arrangement as a control index for unilateral vestibular deficit. Neuroreport 14(7):1075–1079. https://doi.org/10.1097/01.wnr.0000070827.57864.49 CrossRef

Alessandrini M, Micarelli A, Bruno E, Ottaviani F, Conetta M, Cormano A et al (2013) Intranasal administration of hyaluronan as a further resource in olfactory performance in multiple chemical sensitivity syndrome. Int J Immunopathol Pharmacol 26(4):1019–1025. https://doi.org/10.1177/039463201302600424 CrossRef

Alessandrini M, Micarelli A, Chiaravalloti A, Candidi M, Bruno E, Di Pietro B et al (2014) Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects. Sci Rep 4:5146. https://doi.org/10.1038/srep05146 CrossRef

Alessandrini M, Micarelli A, Chiaravalloti A, Bruno E, Danieli R, Pierantozzi M et al (2016) Involvement of subcortical brain structures during olfactory stimulation in multiple chemical sensitivity. Brain Topogr 29(2):243–252. https://doi.org/10.1007/s10548-015-0453-3 CrossRef

Alobid I, Nogue S, Izquierdo-Dominguez A, Centellas S, Bernal-Sprekelsen M, Mullol J (2014) Multiple chemical sensitivity worsens quality of life and cognitive and sensorial features of sense of smell. Eur Arch Otorhinolaryngol 271(12):3203–3208. https://doi.org/10.1007/s00405-014-3015-5 CrossRef

Andersson L, Bende M, Millqvist E, Nordin S (2009) Attention bias and sensitization in chemical sensitivity. J Psychosom Res 66(5):407–416. https://doi.org/10.1016/j.jpsychores.2008.11.005 CrossRef

Andersson L, Claeson AS, Nyberg L, Stenberg B, Nordin S (2014) Brain responses to olfactory and trigeminal exposure in idiopathic environmental illness (IEI) attributed to smells—an fMRI study. J Psychosom Res 77(5):401–408. https://doi.org/10.1016/j.jpsychores.2014.09.014 CrossRef

Azuma K, Uchiyama I, Takano H, Tanigawa M, Azuma M, Bamba I et al (2013) Changes in cerebral blood flow during olfactory stimulation in patients with multiple chemical sensitivity: a multi-channel near-infrared spectroscopic study. PLoS One 8(11):e80567. https://doi.org/10.1371/journal.pone.0080567 CrossRef

Bailer J, Witthoft M, Bayerl C, Rist F (2007) Syndrome stability and psychological predictors of symptom severity in idiopathic environmental intolerance and somatoform disorders. Psychol Med 37(2):271–281. https://doi.org/10.1017/s0033291706009354 CrossRef

Baliatsas C, van Kamp I, Swart W, Hooiveld M, Yzermans J (2016) Noise sensitivity: Symptoms, health status, illness behavior and co-occurring environmental sensitivities. Environ Res 150:8–13. https://doi.org/10.1016/j.envres.2016.05.029 CrossRef

Bascom R, Meggs WJ, Frampton M, Hudnell K, Killburn K, Kobal G et al (1997) Neurogenic inflammation: with additional discussion of central and perceptual integration of nonneurogenic inflammation. Environ Health Perspect 105(Suppl 2):531–537CrossRef

Bell IR, Miller CS, Schwartz GE (1992) An olfactory-limbic model of multiple chemical sensitivity syndrome: possible relationships to kindling and affective spectrum disorders. Biol Psychiatry 32(3):218–242CrossRef

Bell IR, Hardin EE, Baldwin CM, Schwartz GE (1995) Increased limbic system symptomatology and sensitizability of young adults with chemical and noise sensitivities. Environ Res 70(2):84–97. https://doi.org/10.1006/enrs.1995.1052 CrossRef

Bell IR, Bootzin RR, Davis TP, Hau V, Ritenbaugh C, Johnson KA et al (1996a) Time-dependent sensitization of plasma beta-endorphin in community elderly with self-reported environmental chemical odor intolerance. Biol Psychiatry 40(2):134–143. https://doi.org/10.1016/0006-3223(95)00331-2 CrossRef

Bell IR, Bootzin RR, Ritenbaugh C, Wyatt JK, DeGiovanni G, Kulinovich T et al (1996b) A polysomnographic study of sleep disturbance in community elderly with self-reported environmental chemical odor intolerance. Biol Psychiatry 40(2):123–133. https://doi.org/10.1016/0006-3223(95)00330-4 CrossRef

Bell IR, Brooks AJ, Howerter A, Jackson N, Schwartz GE (2013) Acute electroencephalographic effects from repeated olfactory administration of homeopathic remedies in individuals with self-reported chemical sensitivity. Altern Ther Health Med 19(1):46–57

Brown-DeGagne AM, McGlone J (1999) Multiple chemical sensitivity: a test of the olfactory-limbic model. J Occup Environ Med 41(5):366–377CrossRef

Caccamo D, Cesareo E, Mariani S, Raskovic D, Ientile R, Curro M et al (2013) Xenobiotic sensor- and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population. Oxid Med Cell Longev 2013:831969. https://doi.org/10.1155/2013/831969 CrossRef

Caccappolo E, Kipen H, Kelly-McNeil K, Knasko S, Hamer RM, Natelson B et al (2000) Odor perception: multiple chemical sensitivities, chronic fatigue, and asthma. J Occup Environ Med 42(6):629–638CrossRef

Cardinal RN, Parkinson JA, Hall J, Everitt BJ (2002) Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 26:321–352CrossRef

Caress SM, Steinemann AC (2004) Prevalence of multiple chemical sensitivities: a population-based study in the southeastern United States. Am J Public Health 94(5):746–747CrossRef

Carlsson F, Persson R, Karlson B, Osterberg K, Hansen AM, Garde AH et al (2006) Salivary cortisol and self-reported stress among persons with environmental annoyance. Scand J Work Environ Health 32(2):109–120CrossRef

Chen W, Wang Y, Wang X, Li H (2017) Neural circuits involved in the renewal of extinguished fear. IUBMB Life 69(7):470–478CrossRef

Chiaravalloti A, Pagani M, Micarelli A, Di Pietro B, Genovesi G, Alessandrini M et al (2015) Cortical activity during olfactory stimulation in multiple chemical sensitivity: a (18)F-FDG PET/CT study. Eur J Nucl Med Mol Imaging 42(5):733–740. https://doi.org/10.1007/s00259-014-2969-2 CrossRef

Cullen MR (1987) The worker with multiple chemical sensitivities: an overview. Occup Med 2(4):655–661

Dantoft TM, Elberling J, Brix S, Szecsi PB, Vesterhauge S, Skovbjerg S (2014) An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity. Psychoneuroendocrinology 40:140–150. https://doi.org/10.1016/j.psyneuen.2013.11.012 CrossRef

Dantoft TM, Skovbjerg S, Andersson L, Claeson AS, Engkilde K, Lind N et al (2017) Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session. BMJ Open 7(2):e013879. https://doi.org/10.1136/bmjopen-2016-013879 CrossRef

Das-Munshi J, Rubin GJ, Wessely S (2006) Multiple chemical sensitivities: A systematic review of provocation studies. J Allergy Clin Immunol 118(6):1257–1264. https://doi.org/10.1016/j.jaci.2006.07.046 CrossRef

Das-Munshi J, Rubin GJ, Wessely S (2007) Multiple chemical sensitivities: review. Curr Opin Otolaryngol Head Neck Surg 15(4):274–280CrossRef

Devinsky O, Morrell MJ, Vogt BA (1995) Contributions of anterior cingulate cortex to behaviour. Brain 118(Pt 1):279–306CrossRef

Doty RL, Deems DA, Frye RE, Pelberg R, Shapiro A (1988) Olfactory sensitivity, nasal resistance, and autonomic function in patients with multiple chemical sensitivities. Arch Otolaryngol Head Neck Surg 114(12):1422–1427CrossRef

Eis D, Helm D, Mühlinghaus T, Birkner N, Dietel A, Eikmann T et al (2008) The German Multicentre Study on Multiple Chemical Sensitivity (MCS). Int J Hyg Environ Health 2008 Oct 211(5–6):658–681CrossRef

Etkin A, Egner T, Kalisch R (2011) Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 15:85–93CrossRef

Fernandez M, Bell IR, Schwartz GE (1999) EEG sensitization during chemical exposure in women with and without chemical sensitivity of unknown etiology. Toxicol Ind Health 15(3–4):305–312. https://doi.org/10.1177/074823379901500304 CrossRef

Fiedler N, Giardino N, Natelson B, Ottenweller JE, Weisel C, Lioy P et al (2004) Responses to controlled diesel vapor exposure among chemically sensitive Gulf War veterans. Psychosom Med 66(4):588–598. https://doi.org/10.1097/01.psy.0000127872.53932.75 CrossRef

Georgellis A, Lindelof B, Lundin A, Arnetz B, Hillert L (2003) Multiple chemical sensitivity in male painters; a controlled provocation study. Int J Hyg Environ Health 206(6):531–538. https://doi.org/10.1078/1438-4639-00253 CrossRef

Guyton AC, Hall JE (2000) Textbook of medical physiology. Saunders Company, Philadelphia

Hausteiner C, Bornschein S, Hansen J, Zilker T, Förstl H (2005) Self-reported chemical sensitivity in Germany: a population-based survey. Int J Hyg Environ Health 208(4):271–278CrossRef

Hillert L, Musabasic V, Berglund H, Ciumas C, Savic I (2007) Odor processing in multiple chemical sensitivity. Hum Brain Mapp 28(3):172–182. https://doi.org/10.1002/hbm.20266 CrossRef

Hummel T, Welge-Lüssen A (2006) Taste and smell. An update. Karger, BaselCrossRef

Hummel T, Roscher S, Jaumann MP, Kobal G (1996) Intranasal chemoreception in patients with multiple chemical sensitivities: a double-blind investigation. Regul Toxicol Pharmacol 24(1 Pt 2):S79–S86. https://doi.org/10.1006/rtph.1996.0082 CrossRef

Jastreboff PJ, Jastreboff MM (2015) Decreased sound tolerance: hyperacusis, misophonia, diplacousis, and polyacousis. Handb Clin Neurol 129:87–375

Jones KD, King LA, Mist SD, Bennett RM, Horak FB (2011) Postural control deficits in people with fibromyalgia: a pilot study. Arthritis Res Ther 13(4):R127. https://doi.org/10.1186/ar3432 CrossRef

Kreutzer R, Neutra RR, Lashuay N (1999) Prevalence of people reporting sensitivities to chemicals in a population-based survey. Am J Epidemiol 1(1):1–12 150(CrossRef

Kroupi E, Yazdani A, Vesin JM, Ebrahimi T (2012) Multivariate spectral analysis for identifying the brain activations during olfactory perception. Conf Proc IEEE Eng Med Biol Soc 2012:6172–6175

Lacour M, Zunder T, Schmidtke K, Vaith P, Scheidt C (2005) Multiple chemical sensitivity syndrome (MCS)—suggestions for an extension of the U.S. MCS-case definition. Int J Hyg Environ Health 208(3):141–151. https://doi.org/10.1016/j.ijheh.2005.01.017 CrossRef

Lee YL, Pai MC, Chen JH, Guo YL (2003) Central neurological abnormalities and multiple chemical sensitivity caused by chronic toluene exposure. Occup Med (Lond) 53(7):479–482CrossRef

McDermid AJ, Rollman GB, McCain GA (1996) Generalized hypervigilance in fibromyalgia: evidence of perceptual amplification. Pain 66:44–133CrossRef

McFetridge-Durdle JA, Routledge FS, Sampalli T, Fox R, Livingston H, Adams B (2009) Hemodynamic response to postural shift in women with multiple chemical sensitivities. Biol Res Nurs 10(3):267–273. https://doi.org/10.1177/1099800408324251 CrossRef

Micarelli A, Viziano A, Bruno E, Micarelli E, Alessandrini M (2016a) Vestibular impairment in multiple chemical sensitivity: component analysis findings. J Vestib Res 26(5–6):459–468. https://doi.org/10.3233/VES-160594 CrossRef

Micarelli A, Viziano A, Genovesi G, Bruno E, Ottaviani F, Alessandrini M (2016b) Lack of contralateral suppression in transient-evoked otoacoustic emissions in multiple chemical sensitivity: a clinical correlation study. Noise Health 18(82):143–149. https://doi.org/10.4103/1463-1741.181997 CrossRef

Miller CS, Mitzel HC (1995) Chemical sensitivity attributed to pesticide exposure versus remodeling. Arch Environ Health 50(2):119–129. https://doi.org/10.1080/00039896.1995.9940889 CrossRef

Miller CS, Prihoda TJ (1999) The Environmental Exposure and Sensitivity Inventory (EESI): a standardized approach for measuring chemical intolerances for research and clinical applications. Toxicol Ind Health 15(3–4):370–385. https://doi.org/10.1177/074823379901500311 CrossRef

Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151(4):264–269, w264CrossRef

Ojima M, Tonori H, Sato T, Sakabe K, Miyata M, Ishikawa S et al (2002) Odor perception in patients with multiple chemical sensitivity. Tohoku J Exp Med 198(3):163–173CrossRef

Orriols R, Costa R, Cuberas G, Jacas C, Castell J, Sunyer J (2009) Brain dysfunction in multiple chemical sensitivity. J Neurol Sci 287(1–2):72–78. https://doi.org/10.1016/j.jns.2009.09.003 CrossRef

Osterberg K, Orbaek P, Karlson B, Akesson B, Bergendorf U (2003) Annoyance and performance during the experimental chemical challenge of subjects with multiple chemical sensitivity. Scand J Work Environ Health 29(1):40–50CrossRef

Osterberg K, Persson R, Karlson B, Orbaek P (2004) Annoyance and performance of three environmentally intolerant groups during experimental challenge with chemical odors. Scand J Work Environ Health 30(6):486–496CrossRef

Pall ML (2003) Elevated nitric oxide/peroxynitrite theory of multiple chemical sensitivity: central role of N-methyl-D-aspartate receptors in the sensitivity mechanism. Environ Health Perspect 111(12):1461–1464CrossRef

Palmquist E, Claeson AS, Neely G, Stenberg B, Nordin S (2014) Overlap in prevalence between various types of environmental intolerance. Int J Hyg Environ Health 217(4–5):427–434. https://doi.org/10.1016/j.ijheh.2013.08.005 CrossRef

Papo D, Eberlein-Konig B, Berresheim HW, Huss-Marp J, Grimm V, Ring J et al (2006) Chemosensory function and psychological profile in patients with multiple chemical sensitivity: comparison with odor-sensitive and asymptomatic controls. J Psychosom Res 60(2):199–209. https://doi.org/10.1016/j.jpsychores.2005.06.075 CrossRef

Ross PM, Whysner J, Covello VT, Kuschner M, Rifkind AB, Sedler MJ et al (1999) Olfaction and symptoms in the multiple chemical sensitivities syndrome. Prev Med 28(5):467–480CrossRef

Rubin GJ, Nieto-Hernandez R, Wessely S (2010) Idiopathic Environmental Intolerance attributed to electromagnetic fields (formerly ‘Electromagnetic Hypersensitivity’): An updated systematic review of provocation studies. Bioelectromagnetics 31:1–11

van Thriel C, Haumann K, Kiesswetter E, Blaszkewicz M, Seeber A (2002) Time courses of sensory irritations due to 2-butanone and ethyl benzene exposure: influences of self-reported multiple chemical sensitivity (sMCS). Int J Hyg Environ Health 204(5–6):367–369CrossRef

Viziano A, Micarelli A, Alessandrini M (2017) Noise sensitivity and hyperacusis in patients affected by multiple chemical sensitivity. Int Arch Occup Environ Health 90(2):189–196. https://doi.org/10.1007/s00420-016-1185-8 CrossRef

Wiesmuller GA, Niggemann H, Weissbach W, Riley F, Maarouf Z, Dott W et al (2008) Sequence variations in subjects with self-reported multiple chemical sensitivity (sMCS): a case-control study. J Toxicol Environ Health A 71(11–12):786–794. https://doi.org/10.1080/15287390801985620 CrossRef

Winder C (2002) Mechanisms of multiple chemical sensitivity. Toxicol Lett 128:85–97CrossRef

Witthoft M, Gerlach AL, Bailer J (2006) Selective attention, memory bias, and symptom perception in idiopathic environmental intolerance and somatoform disorders. J Abnorm Psychol 115:397–407CrossRef

Titel: Perspectives on multisensory perception disruption in idiopathic environmental intolerance: a systematic review
verfasst von: Andrea Viziano
Alessandro Micarelli
Guido Pasquantonio
David Della-Morte
Marco Alessandrini
Publikationsdatum: 07.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 8/2018
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-018-1346-z

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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