Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
European Archives of Oto-Rhino-Laryngology
Erschienen in: European Archives of Oto-Rhino-Laryngology 8/2018

16.06.2018 | Head & Neck

PET/CT and prediction of thyroid cancer in patients with follicular neoplasm or atypia

verfasst von: Thao T. Nguyen, Natascha G. E. Lange, Anne L. Nielsen, Anders Thomassen, Helle Døssing, Christian Godballe, Max Rohde

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 8/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To examine whether addition of 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) to fine needle aspiration biopsy (FNAB) would improve prediction of thyroid cancer in patients with FNAB-derived follicular neoplasm or atypia, classified according to focal, multifocal, diffuse, or no FDG uptake.

Materials and methods

Consecutive patients with FNAB-derived follicular neoplasm or atypia planned for surgery from September 2013 to March 2016 were prospectively included and considered for analysis. All patients underwent preoperative PET/CT and a clinical head and neck examination, including ultrasound of the neck and the thyroid gland. Patients with obvious signs of thyroid malignancy were excluded from the study. Histology of the surgical specimen was used as reference standard for statistical analysis.

Results

Of the 108 patients included (85 women, median age 53.4 years), 31 (29%) had a thyroid nodule that was histologically verified as malignant. Sensitivity and specificity for PET/CT in detection of thyroid cancer was 79 and 32%, respectively, including a derived positive predictive value (PPV) of 31%, and a negative predictive value (NPV) of 79%. Univariate and multivariate analyses showed no significant increase in the risk of thyroid cancer among patients with focal or multifocal FDG uptake compared to patients with no FDG uptake.

Conclusion

Addition of PET/CT to FNAB did not improve prediction of thyroid cancer in patients with FNAB-derived follicular neoplasm or atypia.
Literatur
1.
2.
3.
4.
Cibas ES, Ali SZ (2009) The Bethesda system for reporting thyroid cytopathology. Thyroid 19:1159–1165CrossRefPubMed
5.
Yassa L, Cibas ES, Benson CB et al (2007) Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation. Cancer 111:508–516CrossRefPubMed
6.
Yang J, Schnadig V, Logrono R, Wasserman PG (2007) Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer 111:306–315CrossRefPubMed
7.
Baloch ZW, Fleisher S, LiVolsi VA, Gupta PK (2002) Diagnosis of “follicular neoplasm”: a gray zone in thyroid fine-needle aspiration cytology. Diagn Cytopathol 26:41–44CrossRefPubMed
8.
Cramer H (2000) Fine-needle aspiration cytology of the thyroid: an appraisal. Cancer 90:325–329CrossRefPubMed
9.
Garas G, Okabayashi K, Ashrafian H et al (2013) Which hemostatic device in thyroid surgery? A network meta-analysis of surgical technologies. Thyroid 23:1138–1150CrossRefPubMed
10.
Zhang M, Lin O (2016) Molecular testing of thyroid nodules: a review of current available tests for fine-needle aspiration specimens. Arch Pathol Lab Med 140:1338–1344CrossRefPubMed
11.
Bartolazzi A, Orlandi F, Saggiorato E et al (2008) Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study. Lancet Oncol 9:543–549CrossRefPubMed
12.
de Matos PS, Ferreira AP, de Oliveira Facuri F, Assumpcao LV, Metze K, Ward LS (2005) Usefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy. Histopathology 47:391–401CrossRefPubMed
13.
Saggiorato E, De Pompa R, Volante M et al (2005) Characterization of thyroid ‘follicular neoplasms’ in fine-needle aspiration cytological specimens using a panel of immunohistochemical markers: a proposal for clinical application. Endocr Relat Cancer 12:305–317CrossRefPubMed
14.
Kapoor V, McCook BM, Torok FS (2004) An introduction to PET-CT imaging. RadioGraphics 24:523–543CrossRefPubMed
15.
Soelberg KK, Bonnema SJ, Brix TH, Hegedus L (2012) Risk of malignancy in thyroid incidentalomas detected by 18F-fluorodeoxyglucose positron emission tomography: a systematic review. Thyroid 22:918–925CrossRefPubMed
16.
Chen W, Parsons M, Torigian DA, Zhuang H, Alavi A (2009) Evaluation of thyroid FDG uptake incidentally identified on FDG-PET/CT imaging. Nucl Med Commun 30:240–244CrossRefPubMed
17.
Vriens D, de Wilt JH, van der Wilt GJ, Netea-Maier RT, Oyen WJ, de Geus-Oei LF (2011) The role of [18F]-2-fluoro-2-deoxy-d-glucose-positron emission tomography in thyroid nodules with indeterminate fine-needle aspiration biopsy: systematic review and meta-analysis of the literature. Cancer 117:4582–4594CrossRefPubMed
18.
Kim TY, Kim WB, Ryu JS, Gong G, Hong SJ, Shong YK (2005) 18F-fluorodeoxyglucose uptake in thyroid from positron emission tomogram (PET) for evaluation in cancer patients: high prevalence of malignancy in thyroid PET incidentaloma. Laryngoscope 115:1074–1078CrossRefPubMed
19.
Are C, Hsu JF, Schoder H, Shah JP, Larson SM, Shaha AR (2007) FDG-PET detected thyroid incidentalomas: need for further investigation? Ann Surg Oncol 14:239–247CrossRefPubMed
20.
Chen YK, Ding HJ, Chen KT et al (2005) Prevalence and risk of cancer of focal thyroid incidentaloma identified by 18F-fluorodeoxyglucose positron emission tomography for cancer screening in healthy subjects. Anticancer Res 25:1421–1426PubMed
21.
Yi JG, Marom EM, Munden RF et al (2005) Focal uptake of fluorodeoxyglucose by the thyroid in patients undergoing initial disease staging with combined PET/CT for non-small cell lung cancer. Radiology 236:271–275CrossRefPubMed
22.
Hsieh HLS, Yang B, Chu Y, Chang C, Liu R (2003) The clinical relevance of thyroid incidentalomas detected by 18F-fluorodeoxyglucose positron emission tomography. Nucl Med Sci 16:53–58
23.
Boerner AR, Voth E, Theissen P, Wienhard K, Wagner R, Schicha H (1998) Glucose metabolism of the thyroid in Graves’ disease measured by F-18-fluoro-deoxyglucose positron emission tomography. Thyroid 8:765–772CrossRefPubMed
24.
25.
Abadi P, Johansen A, Godballe C, Gerke O, Hoilund-Carlsen PF, Thomassen A (2017) 18F-FDG PET/CT to differentiate malignant necrotic lymph node from benign cystic lesions in the neck. Ann Nucl Med 31:101–108CrossRefPubMed
26.
Kresnik E, Gallowitsch HJ, Mikosch P et al (2003) Fluorine-18-fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an endemic goiter area. Surgery 133:294–299CrossRefPubMed
27.
de Geus-Oei LF, Pieters GF, Bonenkamp JJ et al (2006) 18F-FDG PET reduces unnecessary hemithyroidectomies for thyroid nodules with inconclusive cytologic results. J Nucl Med 47:770–775PubMed
28.
Sebastianes FM, Cerci JJ, Zanoni PH et al (2007) Role of 18F-fluorodeoxyglucose positron emission tomography in preoperative assessment of cytologically indeterminate thyroid nodules. J Clin Endocrinol Metab 92:4485–4488CrossRefPubMed
29.
Hales NW, Krempl GA, Medina JE (2008) Is there a role for fluorodeoxyglucose positron emission tomography/computed tomography in cytologically indeterminate thyroid nodules? Am J Otolaryngol 29:113–118CrossRefPubMed
30.
Traugott AL, Dehdashti F, Trinkaus K et al (2010) Exclusion of malignancy in thyroid nodules with indeterminate fine-needle aspiration cytology after negative 18F-fluorodeoxyglucose positron emission tomography: interim analysis. World J Surg 34:1247–1253CrossRefPubMedPubMedCentral
31.
Kim JM, Ryu JS, Kim TY et al (2007) 18F-fluorodeoxyglucose positron emission tomography does not predict malignancy in thyroid nodules cytologically diagnosed as follicular neoplasm. J Clin Endocrinol Metab 92:1630–1634CrossRefPubMed
32.
Deandreis D, Al Ghuzlan A, Auperin A et al (2012) Is (18)F-fluorodeoxyglucose-PET/CT useful for the presurgical characterization of thyroid nodules with indeterminate fine needle aspiration cytology? Thyroid 22:165–172CrossRefPubMed
33.
Mitchell JC, Grant F, Evenson AR, Parker JA, Hasselgren PO, Parangi S (2005) Preoperative evaluation of thyroid nodules with 18FDG-PET/CT. Surgery 138:1166–1174 discussion 1174 – 1165.CrossRefPubMed
34.
35.
Cohen MS, Arslan N, Dehdashti F et al (2001) Risk of malignancy in thyroid incidentalomas identified by fluorodeoxyglucose-positron emission tomography. Surgery 130:941–946CrossRefPubMed
36.
Kang KW, Kim SK, Kang HS et al (2003) Prevalence and risk of cancer of focal thyroid incidentaloma identified by 18F-fluorodeoxyglucose positron emission tomography for metastasis evaluation and cancer screening in healthy subjects. J Clin Endocrinol Metab 88:4100–4104CrossRefPubMed
37.
Pagano L, Sama MT, Morani F et al (2011) Thyroid incidentaloma identified by (1)(8)F-fluorodeoxyglucose positron emission tomography with CT (FDG-PET/CT): clinical and pathological relevance. Clin Endocrinol (Oxf) 75:528–534CrossRef
38.
Bae JS, Chae BJ, Park WC et al (2009) Incidental thyroid lesions detected by FDG-PET/CT: prevalence and risk of thyroid cancer. World J Surg Oncol 7:63CrossRefPubMedPubMedCentral
39.
Kang BJ, O JH, Baik JH, Jung SL, Park YH, Chung SK (2009) Incidental thyroid uptake on F-18 FDG PET/CT: correlation with ultrasonography and pathology. Ann Nucl Med 23:729–737CrossRefPubMed
40.
Pathak KA, Goertzen AL, Nason RW, Klonisch T, Leslie WD (2016) A prospective cohort study to assess the role of FDG-PET in differentiating benign and malignant follicular neoplasms. Ann Med Surg (Lond) 12:27–31CrossRef
Metadaten
Titel
PET/CT and prediction of thyroid cancer in patients with follicular neoplasm or atypia
verfasst von
Thao T. Nguyen
Natascha G. E. Lange
Anne L. Nielsen
Anders Thomassen
Helle Døssing
Christian Godballe
Max Rohde
Publikationsdatum
16.06.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 8/2018
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-018-5030-4

Weitere Artikel der Ausgabe 8/2018

European Archives of Oto-Rhino-Laryngology 8/2018 Zur Ausgabe

Head & Neck

To do or not to do: salvage management for hypopharyngeal cancer after chemoradiation therapy

Otology

Otogenic lateral sinus thrombosis in children: proposal of an experience-based treatment flowchart

Rhinology

The role of oral anticoagulants in epistaxis

Otology

Preservation of the facial and lower cranial nerves in glomus jugulare tumor surgery: modifying our surgical technique for improved outcomes

Review Article

Globus pharyngeus: a review of etiology, diagnostics, and treatment

Rhinology

A novel three-dimensional-printed paranasal sinus–skull base anatomical model

Neu im Fachgebiet HNO

16.04.2024 | HNO-Chirurgie | Nachrichten

HNO-Op. auch mit über 90?

16.04.2024 | Tonsillektomie | Nachrichten

Intrakapsuläre Tonsillektomie gewinnt an Boden

15.04.2024 | Hörsturz | Nachrichten

Bilateraler Hörsturz hat eine schlechte Prognose

08.04.2024 | Larynxpapillomatose | Nachrichten

RRP: Adjuvante HPV-Impfung in jedem Alter empfehlenswert
weitere anzeigen

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen