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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 10/2016

19.03.2016 | Original Article

 PET/MRI in pancreatic and periampullary cancer: correlating diffusion-weighted imaging, MR spectroscopy and glucose metabolic activity with clinical stage and prognosis

verfasst von: Bang-Bin Chen, Yu-Wen Tien, Ming-Chu Chang, Mei-Fang Cheng, Yu-Ting Chang, Chih-Horng Wu, Xin-Jia Chen, Ting-Chun Kuo, Shih-Hung Yang, I-Lun Shih, Hong-Shiee Lai, Tiffany Ting-Fang Shih

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 10/2016

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Abstract

Purpose

To correlate the clinical stage and prognosis of pancreatic or periampullary cancer with the imaging biomarkers on diffusion-weighted imaging, magnetic resonance spectroscopy and glucose metabolic activity derived from integrated PET/MRI.

Methods

This prospective study was approved by the institutional review board and informed consent was obtained. The study group comprised 60 consecutive patients with pancreatic or periampullary cancer who underwent PET/MRI before treatment. The imaging biomarkers were the minimal apparent diffusion coefficient (ADCmin), choline levels, standardized uptake values, metabolic tumour volume (MTV), and total lesion glycolysis (TLG) of the tumours. The relationships between these biomarkers and clinical TNM stage were evaluated using the Pearson test and the Mann-Whitney U test. The area under the receiver operating characteristic curve (AUROC) was used to evaluate accuracy. The correlation between the imaging biomarker and progression-free survival (PFS) was investigated using the Cox proportional hazards model.

Results

ADCmin was significantly lower in N1 and TNM stage 3+ tumours. Choline levels significantly higher in T4 tumours. TLG was significantly higher in T4, N1 and TNM stage 3+ tumours. MTV was significantly higher in T4, N1, M1, and TNM stage 3+ tumours (all P < 0.05). The MTV/ADCmin ratio exhibited the highest AUROC for predicting T4, N1, M1, and advanced TNM stages tumours, and was an independent predictor of PFS (P = 0.018) after adjustment for age, sex, tumour size and stage.

Conclusion

The imaging biomarkers from integrated PET/MRI may predict clinical stage and PFS in patients with pancreatic or periampullary cancer.
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Metadaten
Titel
 PET/MRI in pancreatic and periampullary cancer: correlating diffusion-weighted imaging, MR spectroscopy and glucose metabolic activity with clinical stage and prognosis
verfasst von
Bang-Bin Chen
Yu-Wen Tien
Ming-Chu Chang
Mei-Fang Cheng
Yu-Ting Chang
Chih-Horng Wu
Xin-Jia Chen
Ting-Chun Kuo
Shih-Hung Yang
I-Lun Shih
Hong-Shiee Lai
Tiffany Ting-Fang Shih
Publikationsdatum
19.03.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 10/2016
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-016-3356-y

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