Allergic rhinitis has a very high burden regarding both direct and indirect costs. This makes essential in the management of AR to reduce the clinical severity of the disease and thus to lessen its costs. This particularly concerns allergen immunotherapy (AIT), that, based on its immunological action on the causes of allergy, extends its benefit also after discontinuation of the treatment. From the pharmacoeconomic point of view, any treatment must be evaluated according to its cost-effectiveness, that is, the ratio between the cost of the intervention and its effect. A favorable cost-benefit ratio for AIT was defined, starting from the first studies in the 1990s on subcutaneous immunotherapy (SCIT) in AR patients, that highlighted a clear advantage on costs over the treatment with symptomatic drugs. Such outcome was confirmed also for sublingual immunotherapy (SLIT), that has also the advantage on SCIT to be free of the cost of the injections. Here we review the available literature on pharmacoeconomic data for SLIT with the 5-grass pollen tablets.
The International Study of Asthma and Allergies in Childhood (ISAAC). Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhino conjunctivitis, and atopic eczema. Lancet. 1998;351:1225–32. CrossRef
Mackowiak JI. The health and economic impact of rhinitis. Am J Manag Care. 1997;3:S8–18.
Medical expenditure panel survey. Statistical brief #204: allergic rhinitis: trends in use and expenditures, 2000 and 2005. 2008. http://www.meps.ahrq.gov/mepsweb/data_files/publications/st204/stat204.pdf.
Marcellusi A, Viti R, Incorvaia C, et al. Direct and indirect costs associated with respiratory allergic diseases in Italy. A probabilistic cost of illness study. Recenti Prog Med. 2015;106:517–27. PubMed
Vuurman EF, van Veggel LM, Uitenwijk MM, et al. Seasonal allergic rhinitis and antihistamine effect on children’s learning. Ann Allergy. 1993;71:121–6. PubMed
Bousquet J, Lockey RF, Malling HJ. WHO Position Paper. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Allergy. 1998;53(Suppl 44):4–30.
Buchner K, Siepe M. Nutzen der Hyposensibilierung unter wirtschaftlichen Aspekten. Allergo J. 1995;4:156–63.
Petersen KD, Gyrd-Hansen D, Dahl R. Health-economic analyses of subcutaneous specific immunotherapy for grass pollen and mite allergy. Allergol Immunopathol. 2005;33:296–302. CrossRef
Ariano R, Berto P, Tracci D, et al. Pharmacoeconomics of allergen immunotherapy compared with symptomatic drug treatment in patients with allergic rhinitis and asthma. Allergy Asthma Proc. 2006;27:159–63. PubMed
Omnes LF, Bousquet J, Scheinmann P, et al. Pharmacoeconomic assessment of specific immunotherapy versus current symptomatic treatment for allergic rhinitis and asthma in France. Eur Ann Allergy Clin Immunol. 2007;39:148–56. PubMed
Wang Z, Hankin CS, Cox L, Bronstone A. Allergen immunotherapy significantly reduces healthcare costs among US adults with allergic rhinitis: a retrospective matched cohort study jointly funded by the AAAAI and ACAAI. J Allergy Clin Immunol. 2011;127(2):150.
Berto P, Bassi M, Incorvaia C, et al. Cost effectiveness of sublingual immunotherapy in children with allergic rhinitis and asthma. Eur Ann Allergy Clin Immunol. 2005;37:303–8. PubMed
Podladnikova J, Krcmova I, Vicek J. Economic evaluation of sublingual vs. subcutaneous allergen immunotherapy. Ann Allergy Asthma Immunol. 2008;100:482–9. CrossRef
- Pharmacoeconomics of sublingual immunotherapy with the 5-grass pollen tablets for seasonal allergic rhinitis
- BioMed Central
Neu im Fachgebiet HNO
Mail Icon II