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Cancer Chemotherapy and Pharmacology
Erschienen in: Cancer Chemotherapy and Pharmacology 3/2016

09.04.2016 | Review Article

Pharmacokinetic variations in cancer patients with liver dysfunction: applications and challenges of pharmacometabolomics

verfasst von: Ali Aboel Dahab, Dhia El-Hag, Gamal M. Moutamed, Sarah Aboel Dahab, Ramadan Abuknesha, Norman W. Smith

Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 3/2016

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Abstract

Purpose

In cancer patients, pharmacokinetic variations between individuals and within individuals due to impairments in organs’ function and other reasons such as genetic polymorphisms represent a major problem in disease management, which can result in unpredictable toxicity and variable antineoplastic effects. Addressing pharmacokinetic variations in cancer patients with liver dysfunction and their implications on anticancer and analgesic drugs, in addition to the use of advanced analytical techniques such as metabolomics and pharmacometabolomics, to monitor altered kinetic and discover metabolic biomarkers during therapeutic intervention will help in understanding and reducing pharmacokinetic variations of drugs in cancer patients as a step forward towards personalised medicine.

Methods

Reviewing published literature addressing and/or related to complications resulting from altered pharmacokinetics (PKs) in cancer patients with liver dysfunction, anticancer and analgesic drugs, evaluating recent advances of pharmacokinetic detection using metabolomics/pharmacometabolomics and the challenges that are currently facing these techniques.

Results

The current situation presents a pressing need to reduce pharmacokinetic variations of drugs in cancer patients. Although most of the omics technologies are not entirely focussed on the study of pharmacokinetic variations and some studies are met with uncertainty, the use of pharmacometabolomics combined with other omics technology such as pharmacogenomics can provide clues to personalised cancer treatments by providing useful information about the cancer patient’s response to medical interventions via identification of patients’ dependent variables, understanding of correlations between individuals and population PKs, and therapy outcomes to achieve optimum therapeutic effects with minimum toxicity. We also propose an approach for PKs' evaluation using pharmacometabolomics.
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Metadaten
Titel
Pharmacokinetic variations in cancer patients with liver dysfunction: applications and challenges of pharmacometabolomics
verfasst von
Ali Aboel Dahab
Dhia El-Hag
Gamal M. Moutamed
Sarah Aboel Dahab
Ramadan Abuknesha
Norman W. Smith
Publikationsdatum
09.04.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Cancer Chemotherapy and Pharmacology / Ausgabe 3/2016
Print ISSN: 0344-5704
Elektronische ISSN: 1432-0843
DOI
https://doi.org/10.1007/s00280-016-3028-4

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