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Journal of Natural Medicines
Erschienen in:

29.11.2024 | Note

Pharmacokinetics of seven major components in Aβ1-42-treated rats after oral administration of an aqueous extract of Curculiginis Rhizoma and Epimedii Folium

verfasst von: Junzuo Zheng, Jun Wang, Linlin Chen, Xuelian Jiang, Xuesong Zhang, Wenqi Ai, Yuman Xie, Ping Wang, Zhou Lan, Xiaoping Ding

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2025

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Abstract

Alzheimer’s disease (AD) is the main cause of dementia. Aβ-mediated neuroinflammation plays a crucial role in the development of AD. Curculiginis Rhizoma and Epimedii Folium, frequently used in combination for their synergistic effects, have shown promise for cognitive improvement and anti-inflammatory properties in previous studies. This study, for the first time, investigates the pharmacokinetic profile of seven key compounds in the aqueous extract of Curculiginis Rhizoma and Epimedii Folium (CREF) in both normal and Aβ1-42-treated rats. A validated high-performance liquid chromatography–tandem triple quadrupole mass (HPLC–QQQ-MS) method was used to simultaneously quantify curculigoside, orcinol glucoside, icariin, epimedin B/C, baohuoside I, and magnoflorine in rat plasma. Results revealed significant increases in AUC0-∞ and Cmax values for curculigoside, orcinol glucoside, epimedin B, icariin, and magnoflorine in Aβ1-42-treated rats compared to normal rats, accompanied by decreased plasma clearance (CL). These findings suggest that the pathological condition induced by Aβ1-42 significantly affects the pharmacokinetic characteristics of components in CREF, potentially leading to increased bioavailability in a cognitive impairment model. This discovery provides a novel perspective for exploring the mechanism of CREF’s therapeutic effects on cognitive impairment.

Graphical abstract

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Metadaten
Titel
Pharmacokinetics of seven major components in Aβ1-42-treated rats after oral administration of an aqueous extract of Curculiginis Rhizoma and Epimedii Folium
verfasst von
Junzuo Zheng
Jun Wang
Linlin Chen
Xuelian Jiang
Xuesong Zhang
Wenqi Ai
Yuman Xie
Ping Wang
Zhou Lan
Xiaoping Ding
Publikationsdatum
29.11.2024
Verlag
Springer Nature Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2025
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-024-01861-8

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