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04.06.2016 | ORIGINAL ARTICLE

Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen

verfasst von: Rangel L. Silva, Fernanda V. Castanheira, Jozi G. Figueiredo, Gabriel S. Bassi, Sérgio H. Ferreira, Fernando Q. Cunha, Thiago M. Cunha, Alexandre Kanashiro

Erschienen in: Inflammation | Ausgabe 4/2016

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Abstract

The aim of this study was to identify the effect of beta-adrenergic receptor activation on neutrophil migration in experimental peritonitis elucidating the neuroimmune components involved such as nicotinic receptors and the spleen. Mice pre-treated with mecamylamine (nicotinic antagonist) and propranolol (beta-adrenergic antagonist) or splenectomized animals were treated with isoproterenol (beta-adrenergic agonist) prior to intraperitoneal injection of carrageenan. After 4 h, the infiltrating neutrophils and the local cytokine/chemokine levels were evaluated in the peritoneal lavage. The effect of isoproterenol on neutrophil chemotaxis was investigated in a Boyden chamber. Isoproterenol inhibited neutrophil trafficking, reducing the cytokine/chemokine release and neutrophil chemotaxis. Surprisingly, the isoproterenol effect on neutrophil migration was totally reverted by splenectomy and mecamylamine pre-treatment. In contrast, the inhibitory effect of nicotine on neutrophil migration was abrogated only by splenectomy but not by propranolol pre-treatment. Collectively, our data show that beta-adrenergic receptor activation regulates the acute neutrophil recruitment via splenic nicotinic receptor.

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Titel: Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen
verfasst von: Rangel L. Silva
Fernanda V. Castanheira
Jozi G. Figueiredo
Gabriel S. Bassi
Sérgio H. Ferreira
Fernando Q. Cunha
Thiago M. Cunha
Alexandre Kanashiro
Publikationsdatum: 04.06.2016
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 4/2016
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-016-0372-9

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Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen

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