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Erschienen in:

28.01.2022 | Original Article

Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice

verfasst von: Huili Li, Ting Cao, Weimin Ding, Liwen Liang, Guo-Chang Fan, Lina Qu, Tianqing Peng

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 4/2022

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Abstract

Microgravity conditions cause myocardial abnormalities with limited therapeutic approaches. We reported that NADPH oxidase-derived reactive oxygen species contribute to microgravity-induced myocardial abnormalities. This study investigated whether pharmacological inhibition of Rac1 protected the heart during microgravity. Simulated microgravity was induced by tail-suspension in mice. Tail-suspension for 28 days increased Rac1 activity in hearts, reduced heart weight and cross-sectional areas of cardiomyocytes, indicative of myocardial atrophy, and myocardial dysfunction. Administration of NSC23766, a selective inhibitor of Rac1, or atorvastatin reported to inhibit Rac1 activation, attenuated myocardial atrophy and preserved myocardial function in tail-suspended mice. These protective effects of Rac1 inhibition were associated with inhibition of NADPH oxidase activation and a reduction of oxidative stress. Our finding may inform a future clinical trial using atorvastatin to prevent myocardial abnormalities under microgravity conditions.

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Metadaten
Titel
Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice
verfasst von
Huili Li
Ting Cao
Weimin Ding
Liwen Liang
Guo-Chang Fan
Lina Qu
Tianqing Peng
Publikationsdatum
28.01.2022
Verlag
Springer US
Erschienen in
Journal of Cardiovascular Translational Research / Ausgabe 4/2022
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-021-10197-7

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