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Erschienen in: Translational Stroke Research 1/2016

01.02.2016 | Review Article

Pharmacological Preventions of Brain Injury Following Experimental Germinal Matrix Hemorrhage: an Up-to-Date Review

verfasst von: Jun Tang, Yihao Tao, Bing Jiang, Qianwei Chen, Feng Hua, John Zhang, Gang Zhu, Zhi Chen

Erschienen in: Translational Stroke Research | Ausgabe 1/2016

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Abstract

Germinal matrix hemorrhage (GMH) is defined as the rupture of immature blood vessels in the subependymal zone of premature infants with significant mortality and morbidity. Considering the notable social and ecological stress brought by GMH-induced brain injury and sequelae, safe and efficient pharmacological preventions are badly needed. Currently, several appropriate animal models are available to mimic the clinical outcomes of GMH in human patients. In the long run, hemorrhagic strokes are the research target. Previously, we found that minocycline was efficient to alleviate GMH-induced brain edema and posthemorrhagic hydrocephalus (PHH) in rats, which may be closely related to the activation of cannabinoid receptor 2 (CB2R). However, how the two molecules correlate and the underlined molecular pathway remain unknown. To extensively understand current experimental GMH treatment, this literature review critically evaluates existing therapeutic strategies, potential treatments, and potentially involved molecular mechanisms. Each strategy has its own advantages and disadvantages. Some of the mechanisms are still controversial, requiring an increasing number of animal experiments before the therapeutic strategy would be widely accepted.
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Metadaten
Titel
Pharmacological Preventions of Brain Injury Following Experimental Germinal Matrix Hemorrhage: an Up-to-Date Review
verfasst von
Jun Tang
Yihao Tao
Bing Jiang
Qianwei Chen
Feng Hua
John Zhang
Gang Zhu
Zhi Chen
Publikationsdatum
01.02.2016
Verlag
Springer US
Erschienen in
Translational Stroke Research / Ausgabe 1/2016
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-015-0432-8

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