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Journal of Natural Medicines

Erschienen in:

20.12.2017 | Original Paper

Phenolic compounds from the leaves of Breynia officinalis and their tyrosinase and melanogenesis inhibitory activities

verfasst von: Ayano Sasaki, Yoshi Yamano, Sachiko Sugimoto, Hideaki Otsuka, Katsuyoshi Matsunami, Takakazu Shinzato

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2018

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Abstract

From the EtOAc-soluble fraction of a MeOH extract of the leaves of Breynia officinalis, five new compounds (1–5) along with 11 known compounds (6–16) were isolated. The structures of the new compounds were elucidated by spectroscopic methods and compounds 1–3 were found to be acylated hydroquinone apiofuranosylglucopyranosides, while compound 4 was an acylated hydroquinone glucopyranoside. Compound 5 was shown to be butyl p-coumarate and this seems to be its first isolation from a natural source. The tyrosinase inhibitory activity of all of the isolated compounds was assayed, and the activity was significant in p-coumarate derivatives. The most active compound, compound 3, also inhibited melanogenesis in an in vivo whole animal model, zebrafish.

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Titel: Phenolic compounds from the leaves of Breynia officinalis and their tyrosinase and melanogenesis inhibitory activities
verfasst von: Ayano Sasaki
Yoshi Yamano
Sachiko Sugimoto
Hideaki Otsuka
Katsuyoshi Matsunami
Takakazu Shinzato
Publikationsdatum: 20.12.2017
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2018
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1148-8

Springer Medizin

Abstract

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