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Erschienen in: Supportive Care in Cancer 2/2017

21.09.2016 | Original Article

Photobiomodulation therapy in the management of chronic oral graft-versus-host disease

verfasst von: Joel B. Epstein, Judith E. Raber-Durlacher, Michael Lill, Yuliya P. L. Linhares, Jerry Chang, Andrei Barasch, Romée I. C Slief, Margot Geuke, Judith A. E. M. Zecha, Dan M. J. Milstein, D. Tzachanis

Erschienen in: Supportive Care in Cancer | Ausgabe 2/2017

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Abstract

Aim

Patients treated with allogeneic hematopoietic stem cell transplantation (HSCT) may experience oral complications associated with chronic graft-versus-host disease (cGVHD). These complications may significantly affect quality of life, even many years post-HSCT. Current treatment options for oral cGVHD are limited and often include steroid or other immunomodulatory medications, which may not adequately control the oral condition. A non-immunosuppressive intervention for symptomatic relief in oral cGVHD would thus be a welcome addition to the treatment paradigm.

Materials and methods

We report seven cases of oral cGVHD that were treated with photobiomodulation therapy (PBM), previously known as low-level laser therapy (LLLT). Patients underwent at least two PBM treatments per week in addition to local treatment with steroids, and if on systemic therapies, these were either unchanged or dosage was reduced during the period of PBM therapy. Follow-up data is presented for 4 weeks of treatment.

Results

Oral pain, sensitivity, and dry mouth improved in most patients. These findings suggest PBM therapy may represent an additional approach for management of oral cGVHD, and suggest that controlled studies should be conducted to confirm the efficacy and safety of PBM therapy in oral cGVHD and to determine optimal PBM therapy protocols.
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Metadaten
Titel
Photobiomodulation therapy in the management of chronic oral graft-versus-host disease
verfasst von
Joel B. Epstein
Judith E. Raber-Durlacher
Michael Lill
Yuliya P. L. Linhares
Jerry Chang
Andrei Barasch
Romée I. C Slief
Margot Geuke
Judith A. E. M. Zecha
Dan M. J. Milstein
D. Tzachanis
Publikationsdatum
21.09.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 2/2017
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-016-3401-1

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