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Die Dermatologie

Erschienen in:

01.07.2007 | Leitthema

Photodynamische Therapie nichtonkologischer Indikationen

verfasst von: PD Dr. S. Karrer, R.-M. Szeimies

Erschienen in: Die Dermatologie | Ausgabe 7/2007

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Zusammenfassung

Während die Wirksamkeit der topischen photodynamischen Therapie (PDT) in der Behandlung von oberflächlichen, nicht pigmentierten Hauttumoren inzwischen durch klinisch kontrollierte Studien hinreichend belegt ist, liegen nur wenige kontrollierte Studien vor, die die Wirksamkeit der PDT auch in der Behandlung zahlreicher nichtonkologischer Hauterkrankungen zeigen. Im vorliegenden Beitrag wird der Einsatz der PDT bei entzündlichen Dermatosen, Erkrankungen der Talgdrüsen und Haarfollikel, Infektionen der Haut, sklerosierenden Hauterkrankungen und kosmetischen Indikationen vorgestellt und diskutiert.

Aghahosseini F, Arbabi-Kalati F, Fashtami LA et al. (2006) Methylene blue-mediated photodynamic therapy: a possible alternative treatment for oral lichen planus. Las Surg Med 38: 33–38CrossRef

Alexiades-Armenakas M (2006) Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. J Drugs Dermatol 5: 45–55PubMed

Asilian A, Davamin M (2006) Comparison between the efficacy of photodynamic therapy and topical paromomycin in the treatment of Old World cutaneous leishmaniasis: a placebo-controlled, randomized clinical trial. Clin Dermatol 31: 634–637CrossRef

Avram DK, Goldman MP (2004) Effectiveness and safety of ALA-IPL in treating actinic keratoses and photodamage. J Drugs Dermatol 3 [Suppl]: S36–S39

Beattie PE, Dawe RS, Ferguson J, Ibbotson SH (2004) Lack of efficacy and tolerability of topical PDT for psoriasis in comparison with narrowband UVB phototherapy. Clin Exp Dermatol 29: 560–562PubMedCrossRef

Bissonnette R, Shapiro J, Zeng H et al. (2000) Topical photodynamic therapy with 5-aminolaevulinic acid does not induce hair regrowth in patients with extensive alopecia areata. Br J Dermatol 143: 1032–1035PubMedCrossRef

Bissonnette R, Tremblay JF, Juzenas P et al. (2002) Systemic photodynamic therapy with aminolevulinic acid induces apoptosis in lesional T lymphocytes of psoriatic plaques. J Invest Dermatol 119: 77–83PubMedCrossRef

Boehncke WH, König K, Kaufmann R et al. (1994) Photodynamic therapy in psoriasis: suppression of cytokine production in vitro and recording of fluorescence modification during treatment in vivo. Arch Dermatol Res 286: 300–303PubMedCrossRef

Boehncke W-H, Elshorst-Schmidt T, Kaufmann R (2000) Systemic photodynamic therapy improves psoriasis. Arch Dermatol 136: 271–272PubMedCrossRef

10.

Chiu LL, Sun CH, Yeh AT et al. (2005) Photodynamic therapy on keloid fibroblasts in tissue-engineered keratinocyte-fibroblast co-culture. Las Surg Med 37: 231–244CrossRef

11.

Collins P, Robinson DJ, Stringer MR et al. (1997) The variable response of plaque psoriasis after a single treatment with topical 5-aminolevulinic acid photodynamic therapy. Br J Dermatol 137: 743–749PubMedCrossRef

12.

Dierickx CC, Goldenhersch M, Dwyer P et al. (1999) Photodynamic therapy for nevus sebaceus with topical δ-aminolevulinic acid. Arch Dermatol 135: 637–640PubMedCrossRef

13.

Divaris DXG, Kennedy JC, Poittier RH (1990) Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence. Am J Pathol 136: 891–897PubMed

14.

Dover JS, Bhatia AC, Stewart B, Arndt KA (2005) Topical 5-aminolevulinic acid combined with intense pulsed light in the treatment of photoaging. Arch Dermatol 141: 1247–1252PubMedCrossRef

15.

Enk CD, Fritsch C, Jonas F et al. (2003) Treatment of cutaneous leishmaniasis with photodynamic therapy. Arch Dermatol 139: 432–434PubMedCrossRef

16.

Exadaktylou D, Kurwa HA, Calonje E, Barlow RJ (2003) Treatment of Darier‘s disease with photodynamic therapy. Br J Dermatol 149: 606–610PubMedCrossRef

17.

Fabbrocini G, Di Constanzo MP, Riccardo AM et al. (2001) Photodynamic therapy with topical δ-aminolaevulinic acid for the treatment of plantar warts. J Photochem Photobiol B: Biol 61: 30–34

18.

Fehr MK, Chapman CF, Krasieva T et al. (1996) Selective photosensitizer distribution in vulvar condyloma acuminatum after topical application of 5-aminolevulinic acid. Am J Obstet Gynecol 174: 51–57CrossRef

19.

Fehr MK, Hornung R, Degen A et al. (2002) Photodynamic therapy of vulvar and vaginal condyloma and intraepithelial neoplasia using topically applied 5-aminolevulinic acid. Las Surg Med 30: 273–279CrossRef

20.

Frank RG, Bos JD (1996) Photodynamic therapy for condylomata acuminata with local application of 5-aminolevulinic acid. Genitourin Med 72: 70–71PubMed

21.

Fritsch C, Lehmann P, Stahl W et al. (1999) Optimum porphyrin accumulation in epithelial skin tumours and psoriatic lesions after topical application of delta-aminolaevulinic acid. Br J Cancer 79: 1603–1608PubMedCrossRef

22.

Gardlo K, Horska Z, Enk CD et al. (2003) Treatment of cutaneous leishmaniasis by photodynamic therapy. J Am Acad Dermatol 48: 893–896PubMedCrossRef

23.

Gold M, Bridges TM, Bradshaw VL, Boring M (2004) ALA-PDT and blue light therapy for hidradenitis suppurativa. J Drugs Dermatol 3: 3235

24.

Gold MH, Bradsaw VL, Boring MM et al. (2004) Treatment of sebaceous gland hyperplasia by photodynamic therapy with 5-aminolevulinic acid and a blue light source or intense pulsed light source. J Drugs Dermatol 3: S6–9PubMed

25.

Gold MH, Bradshaw VL, Boring MM et al. (2004) The use of a novel intense pulsed light and heat source and ALA-PDT in the treatment of moderate to severe inflammatory acne vulgaris. J Drugs Dermatol 3: S15–19PubMed

26.

Gold MH, Bradshaw VL, Boring MM et al. (2006) Split-face comparison of photodynamic therapy with 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone for photodamage. Dermatol Surg 32: 795–801PubMedCrossRef

27.

Goldman MP, Atkin D, Kincaid S (2002) PDT/ALA in the treatment of actinic damage: real world experience. Las Surg Med [Suppl] 14: 79

28.

Goldman MP, Boyce SM (2003) A single-center study of aminolevulinic acid and 417 nm photodynamic therapy in the treatment of moderate and severe acne vulgaris. J Drugs Dermatol 2: 393–396PubMed

29.

Grossman M, Wimberly J, Dwyer P (1995) Photodynamic therapy for hirsutism. Lasers Surg Med Suppl 7: 44

30.

Heidenheim M, Jemec GBE (2006) Succesful treatment of necrobiosis lipoidica diabeticorum with photodynamic therapy. Arch Dermatol 142: 1548–1550PubMedCrossRef

31.

Herzinger T, Wienecke R, Weisenseel P et al. (2005) Photodynamic therapy of genital condylomata in men. Clin Exp Dermatol 31: 51–53CrossRef

32.

Hillemanns P, Untch M, Pröve F et al. (1999) Photodynamic therapy of vulvar lichen sclerosus with 5-aminolevulinic acid. Obstet Gynecol 93: 71–74PubMedCrossRef

33.

Hong SB, Lee MH (2005) Topical aminolevulinic acid-photodynamic therapy for the treatment of acne vulgaris. Photodermatol Photoimmunol Photomed 21: 322–325PubMedCrossRef

34.

Hongcharu W, CR Taylor, Y Chang et al. (2000) Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Invest Dermatol 115: 183–192PubMedCrossRef

35.

Hörfelt C, Funk J, Frohm-Nilsson M et al. (2006) Topical methyl aminolaevulinate photodynamic therapy for treatment of facial acne vulgaris: resutls of a randomized, controlled study. Br J Dermatol 155: 608–613PubMedCrossRef

36.

Itoh Y, Ninomiya Y, Tajima S, Ishibashi A (2001) Photodynamic therapy of acne vulgaris with topical d-aminolevulinic acid and incoherent light in Japanese patients. Br J Dermatol 144: 575–579PubMedCrossRef

37.

Karrer S, Szeimies RM, Abels C et al. (1999) Epidermodysplasia verruciformis treated using topical 5-aminolaevulinic acid photodynamic therapy. Br J Dermatol 140: 935–938PubMedCrossRef

38.

Karrer S, Abels C, Landthaler M, Szeimies RM (2000) Topical photodynamic therapy for localized scleroderma. Acta Dermato Venereol 80: 26–27CrossRef

39.

Karrer S, Abels C, Wimmershoff MB et al. (2002) Successful treatment of cutaneous sarcoidosis using topical photodynamic therapy. Arch Dermatol 138: 581–584PubMedCrossRef

40.

Karrer S, Bosserhoff AK, Weiderer P et al. (2003) Influence of 5-aminolevulinic acid and red light on collagen metabolism of human dermal fibroblasts. J Invest Dermatol 120: 325–331PubMedCrossRef

41.

Karrer S, Bosserhoff AK, Weiderer P et al. (2004) Keratinocyte-derived cytokines after photodynamic therapy and their paracrine induction of matrix-metalloproteinases in fibroblasts. Br J Dermatol 151: 776–783PubMedCrossRef

42.

Key DJ (2005) Aminolevulinic acid pulsed dye laser photodynamic therapy for the treatment of photoaging. Cosmetic Dermatol 18: 31–36

43.

Kim SK, Ko JE, Kang HY et al. (2007) Combination of topical 5-aminolevulinic acid-photodynamic therapy with carbon dioxide laser for sebaceous hyperplasia. J Am Acad Dermatol 56: 523–524PubMedCrossRef

44.

Kimura M, Itoh Y, Tokuoda Y, Kawashima N (2004) Delta-aminolevulinic acid-based photodynamic therapy for acne on the body. J Dermatol 31: 956–960PubMed

45.

Kirby B, Whitehurst C, Moore JV, Yates VM (1999) Treatment of lichen planus of the penis with photodynamic therapy. Br J Dermatol 141: 765–766PubMedCrossRef

46.

Kleinpenning MM, Smits T, Ewalds E et al. (2006) Heterogeneity of fluorescence in psoriasis after application of 5-aminolaevulinic acid: an immunohistochemical study. Clin Lab Invest 155: 539–545

47.

Leroy D, Deschamps P (1986) Long term side effects after intramuscular injection of hematoporphyrin derivative. Photodermatology 3: 197–199PubMed

48.

Mikasa K, Watanabe D, Kondo C et al. (2005) Topical 5-aminolevulinic acid-based photodynamic therapy for the treatment of a patient with cutaneous pseudolymphomas. J Am Acad Dermatol 53: 911–912PubMedCrossRef

49.

Mizuki D, Kaneko T, Hanada K (2003) Successful treatment of topical photodynamic therapy using 5-aminolevulinic acid for plane warts. Br J Dermatol 149: 1077–1094CrossRef

50.

Monfrecola G, D’Anna F, Delfino M (1987) Topical hematoporphyrin plus UVA for treatment of alopecia areata. Photodermatology 4: 305–306PubMed

51.

Moody BR, McCarthy JE, Hruza GJ (2003) Collagen remodeling after 585-nm pulsed dye laser irradiation: an ultrasonographic analysis. Dermatol Surg 29: 997–999PubMedCrossRef

52.

Nybaek H, Jemec GBE (2005) Photodynamic therapy in the treatment of rosacea. Pharmacol Treat 211: 135–138

53.

Pollok B, Turner D, Stringer MR et al. (2004) Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. Br J Dermatol 151: 616–622CrossRef

54.

Radakovic-Fijan S, Blecha-Thalhammer U, Schleyer V et al. (2005) Topical aminolaevulinic acid-based photodynamic therapy as a treatment option for psoriasis? Results of a randomized, observer-blinded study. Br J Dermatol 152: 279–283PubMedCrossRef

55.

Robinson DJ, Collins P, Stringer MR et al. (1999) Improved response to plaque psoriasis after multiple treatments with topical 5-aminolevulinic acid photodynamic therapy. Acta Dermato Venereol 79: 451–455CrossRef

56.

Rojanamatin J, Choawawanich P (2006) Treatment of inflammatory facial acne vulgaris with intense pulsed light and short contact of topical 5-aminolevulinic acid: a pilot study. Dermatol Surg 32: 991–997PubMedCrossRef

57.

Ross EV, Romero R, Kollias N et al. (1997) Selectivity of protoporphyrin IX fluorescence for condylomata after topical application of 5-aminolaevulinic acid: implications for photodynamic treatment. Br J Dermatol 137: 736–742PubMedCrossRef

58.

Ross EV (2005) Optical treatments for acne. Dermatol Therapy 18: 253–266CrossRef

59.

Ruiz-Rodriguez R, Sanz-Sanchez, T, Cordoba S (2002) Photodynamic photorejuvenation. Dermatol Surg 28: 742–744PubMedCrossRef

60.

Santos MA, Belo VG, Santos G (2005) Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: comparative study. Dermatol Surg 31: 910–915PubMedCrossRef

61.

Schick E, Rück A, Boehncke WH, Kaufmann R (1997) Topical photodynamic therapy using methylene blue and 5-aminolaevulinic acid in psoriasis. J Dermatol Treat 8: 17–19CrossRef

62.

Schleyer V, Radakovic-Fijan S, Karrer S et al. (2006) Disappointing results and low tolerability of photodynamic therapy with topical 5-aminolaevulinic acid in psoriasis. A randomized, double-blind phase I/II study. JEADV 20: 823–828PubMed

63.

Silver H (1937) Psoriasis vulgaris treated with hematoporpyhrin. Arch Dermatol Syph 36: 1118–1119

64.

Smetana Z, Malik Z, Orenstein A et al. (1997) Treatment of viral infections with 5-aminolevulinic acid and light. Lasers Surg Med 21: 351–358PubMedCrossRef

65.

Stefanaki IM, Georgiou S, Themelis GC et al. (2003) In vivo fluorescence kinetics and photodynamic therapy in condylomata acuminate. Br J Dermatol 149: 972–976PubMedCrossRef

66.

Stender IM, Na R, Fogh H et al. (2000) Photodynamic therapy with 5-aminolaevulinic acid or placebo for recalcitrant foot and hand warts: randomised double-blind trial. Lancet 355: 963–966PubMedCrossRef

67.

Strauss RM, Pollock B, Stables GI et al. (2005) Photodynamic therapy using aminolevulinic acid does not lead to clinical improvement in hidradenitis suppurativa. Br J Dermatol 152: 803–829PubMedCrossRef

68.

Stringer MR, P Collins, Robinson DJ et al. (1996) The accumulation of protoporphyrin IX in plaque psoriasis after topical application of 5-aminolevulinic acid indicates a potential for superficial photodynamic therapy. J Invest Dermatol 107: 76–81PubMedCrossRef

69.

Takeda H, Kaneko T, Harada K et al. (2005) Successful treatment of lymphadenosis benigna cutis with topical photodynamic therapy with delta-aminolevulinic acid. Dermatol 211: 264–266CrossRef

70.

Taub AF (2004) Photodynamic therapy for the treatment of acne: a pilot study. J Drugs Dermatol 3: S10–14PubMed

71.

Touma D, Yaar M, Whitehead S et al. (2004) A trial of short incubation, broad-area photodynamic therapy for facial actinic keratoses and diffuse photodamage. Arch Dermatol 140: 33–40PubMedCrossRef

72.

Wang XL, Wang HW, Wang HS et al. (2004) Topical 5-aminolaevulinic acid-photodynamic therapy for the treatment of urethral condylomata acuminata.Br J Dermatol 151: 880–885PubMedCrossRef

73.

Wiegell SR, Kongshoj B, Wulf HC (2006) Mycobacterium marinum infection cured by photodynamic therapy. Arch Dermatol 142: 1241–1242PubMedCrossRef

74.

Wiegell SR, Wulf HC (2006) Photodynamic therapy of acne vulgaris using methyl aminolaevulinate: a blinded, randomized, controlled trial. Br J Dermatol 154: 969–976PubMedCrossRef

75.

Wiegell SR, Wulf HC (2006) Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. J Am Acad Dermatol 54: 647–651PubMedCrossRef

76.

Zane C, Capezzera R, Sala R et al. (2007) Clinical and echographic analysis of photodynamic therapy using methylaminolevulinate as sensitizer in the treatment of photodamaged facial skin. Las Surg Med 39: 203–209CrossRef

Titel: Photodynamische Therapie nichtonkologischer Indikationen
verfasst von: PD Dr. S. Karrer
R.-M. Szeimies
Publikationsdatum: 01.07.2007
Verlag: Springer-Verlag
Erschienen in: Die Dermatologie / Ausgabe 7/2007
Print ISSN: 2731-7005
Elektronische ISSN: 2731-7013
DOI: https://doi.org/10.1007/s00105-007-1347-4

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