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01.12.2017 | Review | Ausgabe 1/2017 Open Access

Photophobia in neurologic disorders

Zeitschrift:: Translational Neurodegeneration > Ausgabe 1/2017

Autoren:: Yiwen Wu, Mark Hallett

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Abstract

Photophobia is a common symptom seen in many neurologic disorders, however, its pathophysiology remains unclear. Even the term is ambiguous. In this paper, we review the epidemiology and clinical manifestations of photophobia in neurological disorders, including primary headache, blepharospasm, progressive supranuclear palsy, and traumatic brain injury, discuss the definition, etiology and pathogenesis, and summarize practical methods of diagnosis and treatment.

Lebensohn JE. The nature of photophobia. Arch Ophthalmol. 1934;12:380–3. CrossRef

Selby G, Lance JW. Observations on 500 cases of migraine and allied vascular headache. J Neurol Neurosurg Psychiatry. 1960;23:23–32. CrossRefPubMedPubMedCentral

Ahn AH, Brennan KC. Unanswered questions in headache: so what is photophobia, anyway? Headache. 2013;53(10):1673–4. CrossRefPubMedPubMedCentral

Hattar S, Kumar M, Park A, et al. Central projections of melanopsin-expressing retinal ganglion cells in the mouse. J Comp Neurol. 2006;497(3):326–49. CrossRefPubMedPubMedCentral

Fine PG, Digre KBA. Controlled trial of regional sympatholysis in the treatment of photo-oculodynia syndrome. J Neuroophthalmol. 1995;15(2):90–4. CrossRefPubMed

Digre KB, Brennan KC. Shedding light on photophobia. J Neuroophthalmol. 2012;32(1):68–81. CrossRefPubMedPubMedCentral

Katz BJ, Digre KB. Diagnosis, pathophysiology, and treatment of photophobia. Surv Ophthalmol. 2016;61(4):466–77. CrossRefPubMed

The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia, 2013, 33(9): 629–808.

Cvetkovic VV, Plavec D, Lovrencic-Huzjan A, et al. Prevalence and clinical characteristics of headache in adolescents: a Croatian epidemiological study. Cephalalgia. 2014;34(4):289–97. CrossRefPubMed

10.

Rasmussen BK, Jensen R, Olesen JA. Population-based analysis of the diagnostic criteria of the international headache society. Cephalalgia. 1991;11(3):129–34. CrossRefPubMed

11.

Russell MB, Rasmussen BK, Fenger K, et al. Migraine without aura and migraine with aura are distinct clinical entities: a study of four hundred and eighty-four male and female migraineurs from the general population. Cephalalgia. 1996;16(4):239–45. CrossRefPubMed

12.

Drummond PD, Woodhouse A. Painful stimulation of the forehead increases photophobia in migraine sufferers. Cephalalgia. 1993;13(5):321–4. CrossRefPubMed

13.

Vanagaite J, Pareja JA, Storen O, et al. Light-induced discomfort and pain in migraine. Cephalalgia. 1997;17(7):733–41. CrossRefPubMed

14.

Lovati C, Mariotti C, Giani L, et al. Central sensitization in photophobic and non-photophobic migraineurs: possible role of retino nuclear way in the central sensitization process. Neurol Sci. 2013;34(Suppl 1):S133–5. CrossRefPubMed

15.

Baykan B, Ekizoglu E, Karli N, et al. Characterization of Migraineurs having allodynia: results of a large population-based study. Clin J Pain. 2016;32(7):631–5. CrossRefPubMed

16.

Drummond PDA. Quantitative assessment of photophobia in migraine and tension headache. Headache. 1986;26(9):465–9. CrossRefPubMed

17.

Vingen JV, Pareja JA, Stovner LJ. Quantitative evaluation of photophobia and phonophobia in cluster headache. Cephalalgia. 1998;18(5):250–6. CrossRefPubMed

18.

Main A, Vlachonikolis I, Dowson A. The wavelength of light causing photophobia in migraine and tension-type headache between attacks. Headache. 2000;40(3):194–9. CrossRefPubMed

19.

Irimia P, Cittadini E, Paemeleire K, et al. Unilateral photophobia or phonophobia in migraine compared with trigeminal autonomic cephalalgias. Cephalalgia. 2008;28(6):626–30. CrossRefPubMed

20.

Cittadini E, Goadsby PJ. Hemicrania continua: a clinical study of 39 patients with diagnostic implications. Brain. 2010;133(Pt 7):1973–86. CrossRefPubMed

21.

Cohen AS, Matharu MS, Goadsby PJ. Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA)--a prospective clinical study of SUNCT and SUNA. Brain. 2006;129(Pt 10):2746–60. CrossRefPubMed

22.

Hallett M, Evinger C, Jankovic J, et al. Update on blepharospasm: report from the BEBRF international workshop. Neurology. 2008;71(16):1275–82. CrossRefPubMedPubMedCentral

23.

Adams WH, Digre KB, Patel BC, et al. The evaluation of light sensitivity in benign essential blepharospasm. Am J Ophthalmol. 2006;142(1):82–7. CrossRefPubMed

24.

Judd RA, Digre KB, Warner JE, et al. Shedding light on Blepharospasm: a patient–researcher partnership approach to assessment of photophobia and impact on activities of daily living. Neuro-Ophthalmology. 2009;31(3):49–54. CrossRef

25.

Peckham EL, Lopez G, Shamim EA, et al. Clinical features of patients with Blepharospasm: a report of 240 cases. European journal of neurology the official journal of the European Federation of Neurological. For Soc. 2011;18(3):382.

26.

Herz NL, Yen MT. Modulation of sensory photophobia in essential blepharospasm with chromatic lenses. Ophthalmology. 2005;112(12):2208–11. CrossRefPubMed

27.

Nath U, Ben-Shlomo Y, Thomson RG, et al. Clinical features and natural history of progressive supranuclear palsy: a clinical cohort study. Neurology. 2003;60(6):910–6. CrossRefPubMed

28.

Cooper AD, Josephs KA. Photophobia, visual hallucinations, and REM sleep behavior disorder in progressive supranuclear palsy and corticobasal degeneration: a prospective study. Parkinsonism Relat Disord. 2009;15(1):59–61. CrossRefPubMed

29.

Sihlbom C, Van DHI, Lidell ME, et al. Current treatment options in neurology. Le J Médical Libanais the Lebanese Med J. 2004;52(52):33–8.

30.

Kapoor N, Ciuffreda KJ. Vision disturbances following traumatic brain injury. Curr Treat Options Neurol. 2002;4(4):271–80. CrossRefPubMed

31.

Vos PE, Battistin L, Birbamer G, et al. EFNS guideline on mild traumatic brain injury: report of an EFNS task force. Eur J Neurol. 2002;9(3):207–19. CrossRefPubMed

32.

Capo-Aponte JE, Urosevich TG, Temme LA, et al. Visual dysfunctions and symptoms during the subacute stage of blast-induced mild traumatic brain injury. Mil Med. 2012;177(7):804–13. CrossRefPubMed

33.

Truong JQ, Ciuffreda KJ, Han MH, et al. Photosensitivity in mild traumatic brain injury (mTBI): a retrospective analysis. Brain Inj. 2014;28(10):1283–7. CrossRefPubMed

34.

Ksendzovsky A, Pomeraniec IJ, Zaghloul KA, et al. Clinical implications of the melanopsin-based non-image-forming visual system. Neurology. 2017;88(13):1282–90. CrossRefPubMed

35.

Do MT, Yau KW. Intrinsically photosensitive retinal ganglion cells. Physiol Rev. 2010;90(4):1547–81. CrossRefPubMedPubMedCentral

36.

Berson DM, Dunn FA, Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science. 2002;295(5557):1070–3. CrossRefPubMed

37.

Kawasaki A, Kardon RH. Intrinsically photosensitive retinal ganglion cells. J Neuroophthalmol. 2007;27(3):195–204. CrossRefPubMed

38.

Johnson J, Wu V, Donovan M, et al. Melanopsin-dependent light avoidance in neonatal mice. Proc Natl Acad Sci U S A. 2010;107(40):17374–8. CrossRefPubMedPubMedCentral

39.

Matynia A, Parikh S, Chen B, et al. Intrinsically photosensitive retinal ganglion cells are the primary but not exclusive circuit for light aversion. Exp Eye Res. 2012;105:60–9. CrossRefPubMed

40.

Noseda R, Kainz V, Jakubowski M, et al. A neural mechanism for exacerbation of headache by light. Nat Neurosci. 2010;13(2):239–45. CrossRefPubMedPubMedCentral

41.

Kardon R. Melanopsin and its role in photophobia. Acta Ophthalmol. 2012;90(Supplement s249):0–0.

42.

Okamoto K, Thompson R, Tashiro A, et al. Bright light produces Fos-positive neurons in caudal trigeminal brainstem. Neuroscience. 2009;160(4):858–64. CrossRefPubMed

43.

Noseda R, Constandil L, Bourgeais L, et al. Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain. J Neurosci. 2010;30(43):14420–9. CrossRefPubMed

44.

Dolgonos S, Ayyala H, Evinger C. Light-induced trigeminal sensitization without central visual pathways: another mechanism for photophobia. Invest Ophthalmol Vis Sci. 2011;52(11):7852–8. CrossRefPubMedPubMedCentral

45.

Xue T, Do MT, Riccio A, et al. Melanopsin signalling in mammalian iris and retina. Nature. 2011;479(7371):67–73. CrossRefPubMedPubMedCentral

46.

Rossi HL, Recober A. Photophobia in primary headaches. Headache. 2015;55(4):600–4. CrossRefPubMedPubMedCentral

47.

Recober A, Kaiser EA, Kuburas A, et al. Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP. Neuropharmacology. 2010;58(1):156–65. CrossRefPubMed

48.

Evans RW, Seifert T, Kailasam J, et al. The use of questions to determine the presence of photophobia and phonophobia during migraine. Headache. 2008;48(3):395–7. CrossRefPubMed

49.

Bossini L. Sensibilità alla luce e psicopatologia: validazione del Questionario per la Valutazione della Fotosensibilità (QVF). Headache. 1988;28:124–34. CrossRef

50.

Choi JY. Oh K, Kim BJ, et al. usefulness of a photophobia questionnaire in patients with migraine. Cephalalgia. 2009;29(9):953–9. CrossRefPubMed

51.

Sprenger T, Goadsby PJ. Migraine pathogenesis and state of pharmacological treatment options. BMC Med. 2009;7:71. CrossRefPubMedPubMedCentral

52.

Edvinsson L, Villalon CM, MaassenVanDenBrink A. Basic mechanisms of migraine and its acute treatment. Pharmacol Ther. 2012;136(3):319–33. CrossRefPubMed

53.

Negro A, Lionetto L, Simmaco M, et al. CGRP receptor antagonists: an expanding drug class for acute migraine? Expert Opin Investig Drugs. 2012;21(6):807–18. CrossRefPubMed

54.

Yerry JA, Kuehn D, Finkel AG. Onabotulinum toxin a for the treatment of headache in service members with a history of mild traumatic brain injury: a cohort study. Headache. 2015;55(3):395–406. CrossRefPubMed

55.

Blackburn MK, Lamb RD, Digre KB, et al. FL-41 tint improves blink frequency, light sensitivity, and functional limitations in patients with benign essential blepharospasm. Ophthalmology. 2009;116(5):997–1001. CrossRefPubMedPubMedCentral

Titel: Photophobia in neurologic disorders
Autoren:: Yiwen Wu
Mark Hallett
Publikationsdatum: 01.12.2017
DOI: https://doi.org/10.1186/s40035-017-0095-3
Verlag: BioMed Central
Zeitschrift: Translational Neurodegeneration
Ausgabe 1/2017
Elektronische ISSN: 2047-9158

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