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Erschienen in: Acta Diabetologica 8/2019

21.03.2019 | Review Article

Physical activity and risk of diabetic retinopathy: a systematic review and meta-analysis

verfasst von: Chi Ren, Weiming Liu, Jianqing Li, Yihong Cao, Jiayi Xu, Peirong Lu

Erschienen in: Acta Diabetologica | Ausgabe 8/2019

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Abstract

Aims

Diabetic retinopathy (DR) is an important microvascular complication of diabetes mellitus (DM) and a leading cause of visual impairment and blindness among people of working age. Physical activity (PA) or exercise is critical and beneficial for DM patients, whereas studies evaluating the relationship between PA and DR have yielded inconsistent and inconclusive results. The American Diabetes Association’s “Standards of Medical Care in Diabetes” has also pointed out the indeterminate roles of PA in DR prevention. The purpose of this systematic review and meta-analysis was to explore the association between PA and DR risk.

Methods

Medline (accessed by PubMed), EmBase, and Cochrane Library were systematically searched for studies up to June 2018, and the reference lists of the published articles were searched manually. The association between PA and DR risk was assessed using random-effect meta-analysis.

Results

Twenty-two studies were included in this meta-analysis. PA was found to have a protective association with DR [risk ratio (RR) = 0.94, 95% confidence interval (95% CI) 0.90–0.98, p = 0.005] in diabetic patients, and the impact was more pronounced on vision-threatening DR (RR = 0.89, 95% CI 0.80–0.98, p = 0.02). Sedentary behavior could increase the risk of DR (RR = 1.18, 95% CI 1.01–1.37, p = 0.04). Moderate-intensity PA was likely to have a slight protective effect (RR = 0.76, 95% CI 0.58–1.00, p = 0.05).

Conclusion

PA is associated with lower DR risk, and more studies should focus on the causality between them.
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Metadaten
Titel
Physical activity and risk of diabetic retinopathy: a systematic review and meta-analysis
verfasst von
Chi Ren
Weiming Liu
Jianqing Li
Yihong Cao
Jiayi Xu
Peirong Lu
Publikationsdatum
21.03.2019
Verlag
Springer Milan
Erschienen in
Acta Diabetologica / Ausgabe 8/2019
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-019-01319-4

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