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Erschienen in: Lung 5/2019

01.07.2019 | PULMONARY HYPERTENSION

Physical activity in incident patients with pulmonary arterial and chronic thromboembolic hypertension

verfasst von: Stéphanie Saxer, Mona Lichtblau, Charlotte Berlier, Elisabeth D. Hasler, Esther I. Schwarz, Silvia Ulrich

Erschienen in: Lung | Ausgabe 5/2019

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Abstract

Introduction

The cardinal symptom of pulmonary hypertension (PH) is dyspnea on exertion, leading to decreased activity in daily living. The aim of this study was to analyze daily physical activity in incident patients with arterial or chronic thromboembolic PH (PAH/CTEPH) and to investigate its correlation with pulmonary hemodynamics, symptoms, exercise capacity, and other outcomes.

Methods

Incident patients with PAH/CTEPH had a 1-week activity assessment by the arm-worn accelerometer SenseWear within − 3 months/+ 2 weeks of the diagnostic right heart catheterization (RHC) and baseline assessments including 6-minute walking distance (6MWD). Activity was correlated to RHC data at rest and exercise and to other outcomes.

Results

Thirty-nine PH-patients (24 PAH, 15 CTEPH, 23 females, 65(54;73) years, mean pulmonary artery pressure (mPAP) 38(30;46) mmHg, cardiac output (CO) 5.2(4.6;6.3) l/min, 6MWD 458(300;593) m) were included. 64% had a sedentary lifestyle ( < 5000 steps/day), 26% were moderately active (5000–9999 steps/day), and 10% were active. In a multivariate stepwise regression analysis including age, gender, 6MWD and hemodynamics at rest and during exercise (heart rate, mPAP, stroke volume), the 6MWD was the only independent predictor of steps/day (B = 16.8 (95% CI 11.6–22.0), p < 0.001).

Conclusion

Daily physical activity as steps/day assessed in incident patients with PAH/CTEPH did not well correlate with invasive hemodynamics at rest or during exercise, but very well with the 6MWD. Whether daily activity assessments provide additional information to simple walk distance on risk factor profiles during follow-up in patients with PAH/CTEPH remains to be clarified.
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Metadaten
Titel
Physical activity in incident patients with pulmonary arterial and chronic thromboembolic hypertension
verfasst von
Stéphanie Saxer
Mona Lichtblau
Charlotte Berlier
Elisabeth D. Hasler
Esther I. Schwarz
Silvia Ulrich
Publikationsdatum
01.07.2019
Verlag
Springer US
Erschienen in
Lung / Ausgabe 5/2019
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-019-00248-x

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