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Erschienen in: Radiological Physics and Technology 4/2017

20.11.2017

Physics of epi-thermal boron neutron capture therapy (epi-thermal BNCT)

verfasst von: Ryoichi Seki, Yushi Wakisaka, Nami Morimoto, Masaaki Takashina, Masahiko Koizumi, Hiroshi Toki, Mitsuhiro Fukuda

Erschienen in: Radiological Physics and Technology | Ausgabe 4/2017

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Abstract

The physics of epi-thermal neutrons in the human body is discussed in the effort to clarify the nature of the unique radiologic properties of boron neutron capture therapy (BNCT). This discussion leads to the computational method of Monte Carlo simulation in BNCT. The method is discussed through two examples based on model phantoms. The physics is kept at an introductory level in the discussion in this tutorial review.
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Literatur
1.
Zurück zum Zitat Barth R, Vicente M, Harling O, Kiger WS III, Riley KJ, Binnes PJ, Wagner FM, Suzuki M, Aihara T, Kato I, Kawabata S. Boron Neutron capture therapy of cancer: current status and future prospects. Rad Oncol. 2012;7:146–66.CrossRef Barth R, Vicente M, Harling O, Kiger WS III, Riley KJ, Binnes PJ, Wagner FM, Suzuki M, Aihara T, Kato I, Kawabata S. Boron Neutron capture therapy of cancer: current status and future prospects. Rad Oncol. 2012;7:146–66.CrossRef
2.
Zurück zum Zitat Hopewell JW, Morris GM, Schwint A, Coderre JA. The radiobiological principles of boron neutron capture therapy: a critical review. App Rad Isotopes. 2011;69:1756–9.CrossRef Hopewell JW, Morris GM, Schwint A, Coderre JA. The radiobiological principles of boron neutron capture therapy: a critical review. App Rad Isotopes. 2011;69:1756–9.CrossRef
3.
Zurück zum Zitat Sauerwein WAG, Wittig A, Moss R, Nakagawa Y, editors. Neutron capture therapy, principles and applications. Berlin: Springer-Verlag; 2012. Sauerwein WAG, Wittig A, Moss R, Nakagawa Y, editors. Neutron capture therapy, principles and applications. Berlin: Springer-Verlag; 2012.
4.
Zurück zum Zitat BNCT. From the basic to applications. Tokyo: Association for Nuclear Technology in Medicine, and Japanese Society of Neutron Capture Therapy; 2011. Chap. III and pp 139–141. BNCT. From the basic to applications. Tokyo: Association for Nuclear Technology in Medicine, and Japanese Society of Neutron Capture Therapy; 2011. Chap. III and pp 139–141.
5.
Zurück zum Zitat Kato I, Ono K, Sakurai Y, Ohmae M, Maruhashi A, Imahori Y, Kirihata M, Nakazawa M, Yura Y. Effectiveness of BNCT for recurrent head and neck malignancies. App Rad Isotopes. 2004;61:1069–73.CrossRef Kato I, Ono K, Sakurai Y, Ohmae M, Maruhashi A, Imahori Y, Kirihata M, Nakazawa M, Yura Y. Effectiveness of BNCT for recurrent head and neck malignancies. App Rad Isotopes. 2004;61:1069–73.CrossRef
6.
Zurück zum Zitat Hiratsuka J, Kamitani N, Sasaoka S, Kuwabata C. Cutaneous Melanoma. Radioisotopes. 2015;64:115–21.CrossRef Hiratsuka J, Kamitani N, Sasaoka S, Kuwabata C. Cutaneous Melanoma. Radioisotopes. 2015;64:115–21.CrossRef
7.
Zurück zum Zitat Locher GL. Biological effects and therapeutic possibilities of neutron. Am J Roentgonol. 1936;36:1–13. Locher GL. Biological effects and therapeutic possibilities of neutron. Am J Roentgonol. 1936;36:1–13.
8.
Zurück zum Zitat Chadwick J. The existence of a neutron. Proc R Soc London A. 1932;136:692–708.CrossRef Chadwick J. The existence of a neutron. Proc R Soc London A. 1932;136:692–708.CrossRef
9.
Zurück zum Zitat Soloway AH, Hatanaka H, Davis MA. Penetration ofbrain and brain tumor. VII. Tumor-binding sulfhydry boron compounds1,2. J Med Chem. 1967;10:714–7.CrossRefPubMed Soloway AH, Hatanaka H, Davis MA. Penetration ofbrain and brain tumor. VII. Tumor-binding sulfhydry boron compounds1,2. J Med Chem. 1967;10:714–7.CrossRefPubMed
10.
Zurück zum Zitat Mishima Y, Honda C, Ichihashi M, Obara H, Hiratsuka J, Fukuda H, Karashima H, Kohayashi T, Kanda K, Yoshino K. Treatment of malignantmelanoma by single thermal neutron capture therapy with melanoma-seeking \({}^{10}\)B-compound. Lancet. 1989;334:388–9.CrossRef Mishima Y, Honda C, Ichihashi M, Obara H, Hiratsuka J, Fukuda H, Karashima H, Kohayashi T, Kanda K, Yoshino K. Treatment of malignantmelanoma by single thermal neutron capture therapy with melanoma-seeking \({}^{10}\)B-compound. Lancet. 1989;334:388–9.CrossRef
11.
Zurück zum Zitat Nakagawa Y, Pooh K, Kobayashi T, Kageji T, Uyama S, Matsumura A, Kumada H. Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epi-thermal neutron beams. J Neuro Oncol. 2003;62:87–99. Nakagawa Y, Pooh K, Kobayashi T, Kageji T, Uyama S, Matsumura A, Kumada H. Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epi-thermal neutron beams. J Neuro Oncol. 2003;62:87–99.
12.
Zurück zum Zitat Savolainen S, Kortesniemi M, Timonen M, Reijonen V, Kuusela L, Uusi-Simola J, Salli E, Koivunoro H, Seppälä T, Lönnroth N, Välimäki P, Hyvönen H, Kotiluoto P, Serén T, Kuronen A, Heikkinen S, Kosunen A, Auterinen I. Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20years of experiences. Phys Med. 2013;29:233–48.CrossRefPubMed Savolainen S, Kortesniemi M, Timonen M, Reijonen V, Kuusela L, Uusi-Simola J, Salli E, Koivunoro H, Seppälä T, Lönnroth N, Välimäki P, Hyvönen H, Kotiluoto P, Serén T, Kuronen A, Heikkinen S, Kosunen A, Auterinen I. Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20years of experiences. Phys Med. 2013;29:233–48.CrossRefPubMed
13.
Zurück zum Zitat Sauerwein W, Zurlo A. The EORTIC Boron Neutron Capture Therapy (BNCT) Group: achievements and future projects. Eur J Cancer. 2002;38:S31–4.CrossRefPubMed Sauerwein W, Zurlo A. The EORTIC Boron Neutron Capture Therapy (BNCT) Group: achievements and future projects. Eur J Cancer. 2002;38:S31–4.CrossRefPubMed
14.
Zurück zum Zitat Yu HT, Liu YWH, Lin TY, Wang LW. BNCT treatment plnning of recurrent head and neck cancer using THORplan. Appl Radiat Isot. 2011;69:1907–10.CrossRefPubMed Yu HT, Liu YWH, Lin TY, Wang LW. BNCT treatment plnning of recurrent head and neck cancer using THORplan. Appl Radiat Isot. 2011;69:1907–10.CrossRefPubMed
15.
Zurück zum Zitat Takagaki M, Tomaru N, Maguire JA, Hosmane NS. Future applications of Boron and Gadolinium neutron capture therapy. In: Hosmane NS, editor. Boron science, new technologies and applications. Boca Raton: CRC Press; 2011. p. 243–76.CrossRef Takagaki M, Tomaru N, Maguire JA, Hosmane NS. Future applications of Boron and Gadolinium neutron capture therapy. In: Hosmane NS, editor. Boron science, new technologies and applications. Boca Raton: CRC Press; 2011. p. 243–76.CrossRef
16.
Zurück zum Zitat ICRU Report 90. Key data for ionizing-radiation dosimetry: measurement standards and applications. J ICRU. 2016;14. ICRU Report 90. Key data for ionizing-radiation dosimetry: measurement standards and applications. J ICRU. 2016;14.
17.
Zurück zum Zitat Hall EJ, Giaccia AJ. Radiobiology for the dadiologist. 7th ed. Philadelphia: Lippincott Williams & Wikins; 2012. Hall EJ, Giaccia AJ. Radiobiology for the dadiologist. 7th ed. Philadelphia: Lippincott Williams & Wikins; 2012.
18.
Zurück zum Zitat Valentin J, editor. ICRP Publication 103. The 2007 recommendations of the international commission on radiological protection. Annals ICRP. 2007. Valentin J, editor. ICRP Publication 103. The 2007 recommendations of the international commission on radiological protection. Annals ICRP. 2007.
19.
Zurück zum Zitat Sørensen BS, Overgaard J, Bassler N. In vitro RBE-LET dependence for multiple particle types. Acta Oncologica. 2011;50:757–62.CrossRefPubMed Sørensen BS, Overgaard J, Bassler N. In vitro RBE-LET dependence for multiple particle types. Acta Oncologica. 2011;50:757–62.CrossRefPubMed
20.
Zurück zum Zitat Goorley J, Kiger WS III, Zamenhof RG. Reference dosimetry calculations for neutron capture therapy with comparison of analytical and voxel models. Med Phys. 2002;29:145–56.CrossRefPubMed Goorley J, Kiger WS III, Zamenhof RG. Reference dosimetry calculations for neutron capture therapy with comparison of analytical and voxel models. Med Phys. 2002;29:145–56.CrossRefPubMed
21.
Zurück zum Zitat Caswell RS, Coyne JJ, Randolph KL. Kerma factors for neutron energies below 30 MeV. Rad Res. 1980;83:217–54.CrossRef Caswell RS, Coyne JJ, Randolph KL. Kerma factors for neutron energies below 30 MeV. Rad Res. 1980;83:217–54.CrossRef
22.
Zurück zum Zitat ICRU Report 46. Photon, electron, proton, and neutron interaction data for body tissues ICRU. 1992. Appendix A, Body tissue compositions. ICRU Report 46. Photon, electron, proton, and neutron interaction data for body tissues ICRU. 1992. Appendix A, Body tissue compositions.
24.
Zurück zum Zitat Reichl LE. A modern course on statistical physics. 4th ed. New York. Wiley; 2016. Reichl LE. A modern course on statistical physics. 4th ed. New York. Wiley; 2016.
25.
Zurück zum Zitat Parks DE, Beyster JR, Nelkin MS, Wikner NF. Slow neutron scattering and thermalization with reactor applications. New York: Benjamin; 1970. Parks DE, Beyster JR, Nelkin MS, Wikner NF. Slow neutron scattering and thermalization with reactor applications. New York: Benjamin; 1970.
26.
Zurück zum Zitat Fermi E. A course in neutron physics. In: Collected papers Vol. II. Chicago: University of Chicago Press; 1966. pp. 440–542. Fermi E. A course in neutron physics. In: Collected papers Vol. II. Chicago: University of Chicago Press; 1966. pp. 440–542.
27.
Zurück zum Zitat Fermi E. Nuclear Physics. Chicago: Univ. Chicago Press; 1951. Revised Ed. Chapt.9. Fermi E. Nuclear Physics. Chicago: Univ. Chicago Press; 1951. Revised Ed. Chapt.9.
28.
Zurück zum Zitat Segré E. Nuclei and particles. 2nd Ed. Chap. 12. Reading: W. A. Benjamin; 1977. Segré E. Nuclei and particles. 2nd Ed. Chap. 12. Reading: W. A. Benjamin; 1977.
29.
Zurück zum Zitat McDermott PN. Tutorials in radiotherapy physics. Chap. 5. Boca Raton: CRC Press; 2016. McDermott PN. Tutorials in radiotherapy physics. Chap. 5. Boca Raton: CRC Press; 2016.
30.
Zurück zum Zitat X-5 Monte Carlo Team. MCNP—a general Monte Carlo N-particle transport code, Version 5. Los Alamos Nat. Lab; 2003. LA-UR03-1987. X-5 Monte Carlo Team. MCNP—a general Monte Carlo N-particle transport code, Version 5. Los Alamos Nat. Lab; 2003. LA-UR03-1987.
31.
Zurück zum Zitat Sato T, Niita K, Matsuda N, Hashimoto H, Iwamoto Y, Noda S, Ogawa T, Iwase H, Nakashima H, Fukahori T, Okamura K, Kai T, Chiba S, Furuta T, Sihver L. Particle and Heavy Ion Transport Code System PHITS, Version 2.52. J Nucl Sci Technol. 2013;50:913–23.CrossRef Sato T, Niita K, Matsuda N, Hashimoto H, Iwamoto Y, Noda S, Ogawa T, Iwase H, Nakashima H, Fukahori T, Okamura K, Kai T, Chiba S, Furuta T, Sihver L. Particle and Heavy Ion Transport Code System PHITS, Version 2.52. J Nucl Sci Technol. 2013;50:913–23.CrossRef
32.
Zurück zum Zitat Wessol D, Cohen M, Harkin G, Rossmeier M, Wemple C, Wheeler F. SERA Workshop Lab Manual. 1999. INEEL/EXT-99-00766. Wessol D, Cohen M, Harkin G, Rossmeier M, Wemple C, Wheeler F. SERA Workshop Lab Manual. 1999. INEEL/EXT-99-00766.
33.
Zurück zum Zitat Nigg D, Wemple C, Wessol D, Wheeler F. SERA-an advanced treatment planning system for neutron capture therapy and BNCT. Trans Am Nucl Soc. 1999;80:66. Nigg D, Wemple C, Wessol D, Wheeler F. SERA-an advanced treatment planning system for neutron capture therapy and BNCT. Trans Am Nucl Soc. 1999;80:66.
34.
Zurück zum Zitat Kumada H, Takada K, Yamanashi K, Sakae T, Hatsumura A, Sakurai H. Verification of nuclear data for the Tsukuba plan, a newly developed treatment planning system for boron capture therapy. Appl Radiat Isot. 2015;106:111–5.CrossRefPubMed Kumada H, Takada K, Yamanashi K, Sakae T, Hatsumura A, Sakurai H. Verification of nuclear data for the Tsukuba plan, a newly developed treatment planning system for boron capture therapy. Appl Radiat Isot. 2015;106:111–5.CrossRefPubMed
35.
Zurück zum Zitat IAEA-TECDOC-1223. Current status of neutron therapy. Vienna: IAEA; 2001. IAEA-TECDOC-1223. Current status of neutron therapy. Vienna: IAEA; 2001.
36.
Zurück zum Zitat Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Kinashi Y, Kashino G, Liu Y, Matsumoto T, Yajima S, Tsutsui H, Maruhashi A, Ono K. Characteristics comparison between a cyclotron-based neutron source and KUR-HWNIF for boron neutron capture therapy. Nucl Instr Meth Phys Res B. 2009;267:1970–7.CrossRef Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Kinashi Y, Kashino G, Liu Y, Matsumoto T, Yajima S, Tsutsui H, Maruhashi A, Ono K. Characteristics comparison between a cyclotron-based neutron source and KUR-HWNIF for boron neutron capture therapy. Nucl Instr Meth Phys Res B. 2009;267:1970–7.CrossRef
37.
Zurück zum Zitat Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Mitsumoto T, Fujita K, Kashino G, Kinashi Y, Liu Y, Takada M, Ono K, Maruhashi A. Experimental verification of beam characteristics for cyclotron-based epithermal neutron source (C-BENS). App Rad and Isot. 2011;69:1642–5.CrossRef Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Mitsumoto T, Fujita K, Kashino G, Kinashi Y, Liu Y, Takada M, Ono K, Maruhashi A. Experimental verification of beam characteristics for cyclotron-based epithermal neutron source (C-BENS). App Rad and Isot. 2011;69:1642–5.CrossRef
38.
Zurück zum Zitat Miyatake SI, Kawabata S, Kajimoto Y, Aoki A, Yokoyama K, Yamada M, Kuroiwa T, Tsuji M, Imahori Y, Kirihata M, Sakurai Y, Matsunaga SI, Nagata K, Maruhashi A, Ono K. Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulations: an efficacy study based on findings on neuroimges. J Neurosurg. 2005;103:1000–9.CrossRefPubMed Miyatake SI, Kawabata S, Kajimoto Y, Aoki A, Yokoyama K, Yamada M, Kuroiwa T, Tsuji M, Imahori Y, Kirihata M, Sakurai Y, Matsunaga SI, Nagata K, Maruhashi A, Ono K. Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulations: an efficacy study based on findings on neuroimges. J Neurosurg. 2005;103:1000–9.CrossRefPubMed
39.
Zurück zum Zitat Bisceglie E, Colangelo P, Colonna N, Santorelli P, Variale V. On the optimal energy of epithermalneutron beams for BNCT. Phys Med Biol. 2000;45:49–58.CrossRef Bisceglie E, Colangelo P, Colonna N, Santorelli P, Variale V. On the optimal energy of epithermalneutron beams for BNCT. Phys Med Biol. 2000;45:49–58.CrossRef
40.
Zurück zum Zitat Yanch J, Zhou X-L, Brownell G. A Monte Carlo investigation of the dosimetric properties of monoenergetic neutron beams for neutron capture therapy. Rad Res. 1991;126:1–20.CrossRef Yanch J, Zhou X-L, Brownell G. A Monte Carlo investigation of the dosimetric properties of monoenergetic neutron beams for neutron capture therapy. Rad Res. 1991;126:1–20.CrossRef
41.
Zurück zum Zitat Nuclear Physics European Collaboration Committee (NuPECC). Nuclear Physics for Medicine. Section 10. Strasboug: European Science Foundation; 2014. Nuclear Physics European Collaboration Committee (NuPECC). Nuclear Physics for Medicine. Section 10. Strasboug: European Science Foundation; 2014.
42.
Zurück zum Zitat Thames HD, Hendry JH. Fractionation in raiotherapy. Chap. 2. London: Taylor & Francis; 1987. Thames HD, Hendry JH. Fractionation in raiotherapy. Chap. 2. London: Taylor & Francis; 1987.
43.
Zurück zum Zitat Coderre JA, Makar MS, Micca PL, Nawrocky MM, Liu HB, Joel DD, Slatkin DN, Amols HI. Derivations of relative biological effectiveness for the high-LET radiations reduced during boron neutron capture irradiations of the 9L rat gliosarcoma in vitro and in vivo. Int J Rad Oncol Biol Phys. 1993;27:1121–9.CrossRef Coderre JA, Makar MS, Micca PL, Nawrocky MM, Liu HB, Joel DD, Slatkin DN, Amols HI. Derivations of relative biological effectiveness for the high-LET radiations reduced during boron neutron capture irradiations of the 9L rat gliosarcoma in vitro and in vivo. Int J Rad Oncol Biol Phys. 1993;27:1121–9.CrossRef
44.
Zurück zum Zitat Niemierko A. Reporting and analyzing dose distributions: a concept of equivalent uniform dose. Med Phys. 1997;24:103–10.CrossRefPubMed Niemierko A. Reporting and analyzing dose distributions: a concept of equivalent uniform dose. Med Phys. 1997;24:103–10.CrossRefPubMed
45.
Zurück zum Zitat Suzuki S. A theoretical model for simultaneous mixed irradiation with multiple types of radiation. J Radiat Res. 1998;39:215–21.CrossRefPubMed Suzuki S. A theoretical model for simultaneous mixed irradiation with multiple types of radiation. J Radiat Res. 1998;39:215–21.CrossRefPubMed
46.
Zurück zum Zitat Niemierko A. A generalized concept of equivalent uniform dose (EUD). Med Phys. 1999;26:1100. (Abstract WE-C2-9). Niemierko A. A generalized concept of equivalent uniform dose (EUD). Med Phys. 1999;26:1100. (Abstract WE-C2-9).
47.
Zurück zum Zitat AAPM Task Group 116 of the Therapy Physics Committee. AAPM Report No. 166: The used and QA of biologically related models for treatment planning. College Park: AAPM; 2012. AAPM Task Group 116 of the Therapy Physics Committee. AAPM Report No. 166: The used and QA of biologically related models for treatment planning. College Park: AAPM; 2012.
48.
Zurück zum Zitat Ebert MA. Validity of the EUD and TCP concept as reliable dose indicators. Phys Med Biol. 2000;45:441–57.CrossRefPubMed Ebert MA. Validity of the EUD and TCP concept as reliable dose indicators. Phys Med Biol. 2000;45:441–57.CrossRefPubMed
49.
Zurück zum Zitat Djajaputra D, Wu Q. On relating the generalized equivalent uniform dose formalism to the linear-quadratic model. Med Phys. 2006;33:4481–9.CrossRefPubMed Djajaputra D, Wu Q. On relating the generalized equivalent uniform dose formalism to the linear-quadratic model. Med Phys. 2006;33:4481–9.CrossRefPubMed
50.
Zurück zum Zitat Masunaga S, Sakurai Y, Tanaka H, Tano K, Suzuki M, Kondo N, Nakabayashi M, Nakagawa Y, Watanabe T, Maruhasgi A, Ono K. The dependency of compound biological effectiveness factors on the type and the concentration of administered neutron capture agents in boron neutron capture therapy. Springer Plus. 2014;3:128–38.CrossRefPubMedPubMedCentral Masunaga S, Sakurai Y, Tanaka H, Tano K, Suzuki M, Kondo N, Nakabayashi M, Nakagawa Y, Watanabe T, Maruhasgi A, Ono K. The dependency of compound biological effectiveness factors on the type and the concentration of administered neutron capture agents in boron neutron capture therapy. Springer Plus. 2014;3:128–38.CrossRefPubMedPubMedCentral
51.
Zurück zum Zitat Ono K. An analysis of the structure of the compound biological effectiveness factor. J. Rad Res. 2016;57:i83–9.CrossRef Ono K. An analysis of the structure of the compound biological effectiveness factor. J. Rad Res. 2016;57:i83–9.CrossRef
52.
Zurück zum Zitat Gonzales SJ, Santa Cruz GA. The photon-isoffective dose in boron neutron capture therapy. Rad Res. 2012;178:609–21.CrossRef Gonzales SJ, Santa Cruz GA. The photon-isoffective dose in boron neutron capture therapy. Rad Res. 2012;178:609–21.CrossRef
53.
Zurück zum Zitat Barth RF. Boron neutron capture therapy at the cross roads: Callenges and oppotunities. App Rad Isot. 2009;67:S3–6.CrossRef Barth RF. Boron neutron capture therapy at the cross roads: Callenges and oppotunities. App Rad Isot. 2009;67:S3–6.CrossRef
54.
Zurück zum Zitat Lupton R. Statistics in theory and practice. Chap. 2. Princeton: Princeton University Press; 1993. Lupton R. Statistics in theory and practice. Chap. 2. Princeton: Princeton University Press; 1993.
Metadaten
Titel
Physics of epi-thermal boron neutron capture therapy (epi-thermal BNCT)
verfasst von
Ryoichi Seki
Yushi Wakisaka
Nami Morimoto
Masaaki Takashina
Masahiko Koizumi
Hiroshi Toki
Mitsuhiro Fukuda
Publikationsdatum
20.11.2017
Verlag
Springer Singapore
Erschienen in
Radiological Physics and Technology / Ausgabe 4/2017
Print ISSN: 1865-0333
Elektronische ISSN: 1865-0341
DOI
https://doi.org/10.1007/s12194-017-0430-5

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