Skip to main content
Erschienen in: European Journal of Applied Physiology 11/2015

01.11.2015 | Original Article

Physiological and molecular responses to an acute bout of reduced-exertion high-intensity interval training (REHIT)

verfasst von: R. S. Metcalfe, F. Koumanov, J. S. Ruffino, K. A. Stokes, G. D. Holman, D. Thompson, N. B. J. Vollaard

Erschienen in: European Journal of Applied Physiology | Ausgabe 11/2015

Einloggen, um Zugang zu erhalten

Abstract

Purpose

We have previously shown that 6 weeks of reduced-exertion high-intensity interval training (REHIT) improves \(\dot{V}{\text{O}}_{2}\)max in sedentary men and women and insulin sensitivity in men. Here, we present two studies examining the acute physiological and molecular responses to REHIT.

Methods

In Study 1, five men and six women (age: 26 ± 7 year, BMI: 23 ± 3 kg m−2, \(\dot{V}{\text{O}}_{2}\)max: 51 ± 11 ml kg−1 min−1) performed a single 10-min REHIT cycling session (60 W and two 20-s ‘all-out’ sprints), with vastus lateralis biopsies taken before and 0, 30, and 180 min post-exercise for analysis of glycogen content, phosphorylation of AMPK, p38 MAPK and ACC, and gene expression of PGC1α and GLUT4. In Study 2, eight men (21 ± 2 year; 25 ± 4 kg·m−2; 39 ± 10 ml kg−1 min−1) performed three trials (REHIT, 30-min cycling at 50 % of \(\dot{V}{\text{O}}_{2}\)max, and a resting control condition) in a randomised cross-over design. Expired air, venous blood samples, and subjective measures of appetite and fatigue were collected before and 0, 15, 30, and 90 min post-exercise.

Results

Acutely, REHIT was associated with a decrease in muscle glycogen, increased ACC phosphorylation, and activation of PGC1α. When compared to aerobic exercise, changes in \(\dot{V}{\text{O}}_{2}\), RER, plasma volume, and plasma lactate and ghrelin were significantly more pronounced with REHIT, whereas plasma glucose, NEFAs, PYY, and measures of appetite were unaffected.

Conclusions

Collectively, these data demonstrate that REHIT is associated with a pronounced disturbance of physiological homeostasis and associated activation of signalling pathways, which together may help explain previously observed adaptations once considered exclusive to aerobic exercise.
Literatur
Zurück zum Zitat Allender S, Scarborough P, Peto V, Rayner M, Leal J, Luengo-Fernandez R, Gray A (2008) European cardiovascular disease statistics. European Heart Network, Brussels Allender S, Scarborough P, Peto V, Rayner M, Leal J, Luengo-Fernandez R, Gray A (2008) European cardiovascular disease statistics. European Heart Network, Brussels
Zurück zum Zitat Beaulieu K, Olver TD, Abbott KC, Lemon PW (2015) Energy intake over 2 days is unaffected by acute sprint interval exercise despite increased appetite and energy expenditure. Appl Physiol Nutr Metab 40(1):79–86. doi:10.1139/apnm-2014-0229 CrossRefPubMed Beaulieu K, Olver TD, Abbott KC, Lemon PW (2015) Energy intake over 2 days is unaffected by acute sprint interval exercise despite increased appetite and energy expenditure. Appl Physiol Nutr Metab 40(1):79–86. doi:10.​1139/​apnm-2014-0229 CrossRefPubMed
Zurück zum Zitat Broom DR, Batterham RL, King JA, Stensel DJ (2009) Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. Am J Physiol Regul Integr Comp Physiol 296(1):R29–R35. doi:10.1152/ajpregu.90706.2008 CrossRefPubMed Broom DR, Batterham RL, King JA, Stensel DJ (2009) Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. Am J Physiol Regul Integr Comp Physiol 296(1):R29–R35. doi:10.​1152/​ajpregu.​90706.​2008 CrossRefPubMed
Zurück zum Zitat Chan MH, McGee SL, Watt MJ, Hargreaves M, Febbraio MA (2004) Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction. FASEB J 18(14):1785–1787. doi:10.1096/fj.03-1039fje PubMed Chan MH, McGee SL, Watt MJ, Hargreaves M, Febbraio MA (2004) Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction. FASEB J 18(14):1785–1787. doi:10.​1096/​fj.​03-1039fje PubMed
Zurück zum Zitat Cochran AJ, Percival ME, Tricarico S, Little JP, Cermak N, Gillen JB, Tarnopolsky MA, Gibala MJ (2014) Intermittent and continuous high-intensity exercise training induce similar acute but different chronic muscle adaptations. Exp Physiol 99(5):782–791. doi:10.1113/expphysiol.2013.077453 CrossRefPubMed Cochran AJ, Percival ME, Tricarico S, Little JP, Cermak N, Gillen JB, Tarnopolsky MA, Gibala MJ (2014) Intermittent and continuous high-intensity exercise training induce similar acute but different chronic muscle adaptations. Exp Physiol 99(5):782–791. doi:10.​1113/​expphysiol.​2013.​077453 CrossRefPubMed
Zurück zum Zitat Colley RC, Garriguet D, Janssen I, Craig CL, Clarke J, Tremblay MS (2011) Physical activity of Canadian adults: accelerometer results from the 2007 to 2009 Canadian Health Measures Survey. Health Rep 22(1):7–14PubMed Colley RC, Garriguet D, Janssen I, Craig CL, Clarke J, Tremblay MS (2011) Physical activity of Canadian adults: accelerometer results from the 2007 to 2009 Canadian Health Measures Survey. Health Rep 22(1):7–14PubMed
Zurück zum Zitat Deighton K, Barry R, Connon CE, Stensel DJ (2013) Appetite, gut hormone and energy intake responses to low volume sprint interval and traditional endurance exercise. Eur J Appl Physiol 113(5):1147–1156. doi:10.1007/s00421-012-2535-1 CrossRefPubMed Deighton K, Barry R, Connon CE, Stensel DJ (2013) Appetite, gut hormone and energy intake responses to low volume sprint interval and traditional endurance exercise. Eur J Appl Physiol 113(5):1147–1156. doi:10.​1007/​s00421-012-2535-1 CrossRefPubMed
Zurück zum Zitat Dill DB, Costill DL (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37(2):247–248PubMed Dill DB, Costill DL (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37(2):247–248PubMed
Zurück zum Zitat Esbjornsson-Liljedahl M, Sundberg CJ, Norman B, Jansson E (1999) Metabolic response in type I and type II muscle fibers during a 30-s cycle sprint in men and women. J Appl Physiol 87:1326–1332PubMed Esbjornsson-Liljedahl M, Sundberg CJ, Norman B, Jansson E (1999) Metabolic response in type I and type II muscle fibers during a 30-s cycle sprint in men and women. J Appl Physiol 87:1326–1332PubMed
Zurück zum Zitat Flint A, Raben A, Blundell JE, Astrup A (2000) Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 24(1):38–48. doi:10.1038/sj.ijo.0801083 CrossRefPubMed Flint A, Raben A, Blundell JE, Astrup A (2000) Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 24(1):38–48. doi:10.​1038/​sj.​ijo.​0801083 CrossRefPubMed
Zurück zum Zitat Fuentes T, Guerra B, Ponce-González JG, Morales-Alamo D, Guadalupe-Grau A, Olmedillas H, Rodríguez-García L, Feijoo D, De Pablos-Velasco P, Fernández-Pérez L, Santana A, Calbet JA (2012) Skeletal muscle signalling response to sprint exercise in men and women. Eur J Appl Physiol 112(5):1917–1927. doi:10.1007/s00421-011-2164-0 CrossRefPubMed Fuentes T, Guerra B, Ponce-González JG, Morales-Alamo D, Guadalupe-Grau A, Olmedillas H, Rodríguez-García L, Feijoo D, De Pablos-Velasco P, Fernández-Pérez L, Santana A, Calbet JA (2012) Skeletal muscle signalling response to sprint exercise in men and women. Eur J Appl Physiol 112(5):1917–1927. doi:10.​1007/​s00421-011-2164-0 CrossRefPubMed
Zurück zum Zitat Fuentes T, Ponce-González JG, Morales-Alamo D, de Torres-Peralta R, Santana A, De Pablos-Velasco P, Olmedillas H, Guadalupe-Grau A, Rodríguez-García L, Serrano-Sanchez JA, Guerra B, Calbet JA (2013) Isoinertial and isokinetic sprints: muscle signalling. Int J Sports Med 34(4):285–292. doi:10.1055/s-0032-1312583 PubMed Fuentes T, Ponce-González JG, Morales-Alamo D, de Torres-Peralta R, Santana A, De Pablos-Velasco P, Olmedillas H, Guadalupe-Grau A, Rodríguez-García L, Serrano-Sanchez JA, Guerra B, Calbet JA (2013) Isoinertial and isokinetic sprints: muscle signalling. Int J Sports Med 34(4):285–292. doi:10.​1055/​s-0032-1312583 PubMed
Zurück zum Zitat Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP (2011) American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43(7):1334–1359. doi:10.1249/MSS.0b013e318213fefb CrossRefPubMed Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP (2011) American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43(7):1334–1359. doi:10.​1249/​MSS.​0b013e318213fefb​ CrossRefPubMed
Zurück zum Zitat Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M (2009) Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle. J Appl Physiol 106(3):929–934. doi:10.1152/japplphysiol.90880.2008 CrossRefPubMed Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M (2009) Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle. J Appl Physiol 106(3):929–934. doi:10.​1152/​japplphysiol.​90880.​2008 CrossRefPubMed
Zurück zum Zitat Gillen JB, Percival ME, Ludzki A, Tarnopolsky MA, Gibala MJ (2013) Interval training in the fed or fasted state improves body composition and muscle oxidative capacity in overweight women. Obes. doi:10.1002/oby.20379 Gillen JB, Percival ME, Ludzki A, Tarnopolsky MA, Gibala MJ (2013) Interval training in the fed or fasted state improves body composition and muscle oxidative capacity in overweight women. Obes. doi:10.​1002/​oby.​20379
Zurück zum Zitat Ha J, Daniel S, Broyles SS, Kim KH (1994) Critical phosphorylation sites for acetyl-CoA carboxylase activity. J Biol Chem 269(35):22162–22168PubMed Ha J, Daniel S, Broyles SS, Kim KH (1994) Critical phosphorylation sites for acetyl-CoA carboxylase activity. J Biol Chem 269(35):22162–22168PubMed
Zurück zum Zitat Hazell TJ, Olver TD, Hamilton CD, Lemon PW (2012) Two minutes of sprint-interval exercise elicits 24-hr oxygen consumption similar to that of 30 min of continuous endurance exercise. Int J Sport Nutr Exerc Metab 22(4):276–283PubMed Hazell TJ, Olver TD, Hamilton CD, Lemon PW (2012) Two minutes of sprint-interval exercise elicits 24-hr oxygen consumption similar to that of 30 min of continuous endurance exercise. Int J Sport Nutr Exerc Metab 22(4):276–283PubMed
Zurück zum Zitat Hosoda H, Doi K, Nagaya N, Okumura H, Nakagawa E, Enomoto M, Ono F, Kangawa K (2004) Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clin Chem 50 (6):1077-1080. doi:10.1373/clinchem.2003.025841 Hosoda H, Doi K, Nagaya N, Okumura H, Nakagawa E, Enomoto M, Ono F, Kangawa K (2004) Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clin Chem 50 (6):1077-1080. doi:10.​1373/​clinchem.​2003.​025841
Zurück zum Zitat Karatzaferi C, de Haan A, Ferguson RA, van Mechelen W, Sargeant AJ (2001a) Phosphocreatine and ATP content in human single muscle fibres before and after maximum dynamic exercise. Pflugers Arch 442(3):467–474. doi:10.1007/s004240100552 CrossRefPubMed Karatzaferi C, de Haan A, Ferguson RA, van Mechelen W, Sargeant AJ (2001a) Phosphocreatine and ATP content in human single muscle fibres before and after maximum dynamic exercise. Pflugers Arch 442(3):467–474. doi:10.​1007/​s004240100552 CrossRefPubMed
Zurück zum Zitat Korkiakangas EE, Alahuhta MA, Laitinen JH (2009) Barriers to regular exercise among adults at high risk or diagnosed with type 2 diabetes: a systematic review. Health Promot Int 24(4):416–427. doi:10.1093/heapro/dap031 CrossRefPubMed Korkiakangas EE, Alahuhta MA, Laitinen JH (2009) Barriers to regular exercise among adults at high risk or diagnosed with type 2 diabetes: a systematic review. Health Promot Int 24(4):416–427. doi:10.​1093/​heapro/​dap031 CrossRefPubMed
Zurück zum Zitat Laforgia J, Withers RT, Shipp NJ, Gore CJ (1997) Comparison of energy expenditure elevations after submaximal and supramaximal running. J Appl Physiol 82(2):661–666PubMed Laforgia J, Withers RT, Shipp NJ, Gore CJ (1997) Comparison of energy expenditure elevations after submaximal and supramaximal running. J Appl Physiol 82(2):661–666PubMed
Zurück zum Zitat Little JP, Safdar A, Bishop D, Tarnopolsky MA, Gibala MJ (2011) An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol 300(6):R1303–R1310. doi:10.1152/ajpregu.00538.2010 CrossRefPubMed Little JP, Safdar A, Bishop D, Tarnopolsky MA, Gibala MJ (2011) An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol 300(6):R1303–R1310. doi:10.​1152/​ajpregu.​00538.​2010 CrossRefPubMed
Zurück zum Zitat Liu Z, Cao W (2009) p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus. Endocr Metab Immune Disord Drug Targets 9(1):38–46. doi:10.2174/187153009787582397 CrossRefPubMed Liu Z, Cao W (2009) p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus. Endocr Metab Immune Disord Drug Targets 9(1):38–46. doi:10.​2174/​1871530097875823​97 CrossRefPubMed
Zurück zum Zitat Metcalfe RS, Babraj JA, Fawkner SG, Vollaard NB (2012) Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training. Eur J Appl Physiol 112(7):2767–2775. doi:10.1007/s00421-011-2254-z CrossRefPubMed Metcalfe RS, Babraj JA, Fawkner SG, Vollaard NB (2012) Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training. Eur J Appl Physiol 112(7):2767–2775. doi:10.​1007/​s00421-011-2254-z CrossRefPubMed
Zurück zum Zitat Parolin ML, Chesley A, Matsos MP, Spriet LL, Jones NL, Heigenhauser GJ (1999) Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise. Am J Physiol 277(5 Pt 1):E890–E900PubMed Parolin ML, Chesley A, Matsos MP, Spriet LL, Jones NL, Heigenhauser GJ (1999) Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise. Am J Physiol 277(5 Pt 1):E890–E900PubMed
Zurück zum Zitat Raja MK, Raymer GH, Moran GR, Marsh G, Thompson RT (2006) Changes in tissue water content measured with multiple-frequency bioimpedance and metabolism measured with 31P-MRS during progressive forearm exercise. J Appl Physiol 101(4):1070–1075. doi:10.1152/japplphysiol.01322.2005 CrossRefPubMed Raja MK, Raymer GH, Moran GR, Marsh G, Thompson RT (2006) Changes in tissue water content measured with multiple-frequency bioimpedance and metabolism measured with 31P-MRS during progressive forearm exercise. J Appl Physiol 101(4):1070–1075. doi:10.​1152/​japplphysiol.​01322.​2005 CrossRefPubMed
Zurück zum Zitat Rakobowchuk M, Tanguay S, Burgomaster KA, Howarth KR, Gibala MJ, MacDonald MJ (2008) Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans. Am J Physiol Regul Integr Comp Physiol 295(1):R236–R242. doi:10.1152/ajpregu.00069.2008 PubMedCentralCrossRefPubMed Rakobowchuk M, Tanguay S, Burgomaster KA, Howarth KR, Gibala MJ, MacDonald MJ (2008) Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans. Am J Physiol Regul Integr Comp Physiol 295(1):R236–R242. doi:10.​1152/​ajpregu.​00069.​2008 PubMedCentralCrossRefPubMed
Zurück zum Zitat Sevits KJ, Melanson EL, Swibas T, Binns SE, Klochak AL, Lonac MC, Peltonen GL, Scalzo RL, Schweder MM, Smith AM, Wood LM, Melby CL, Bell C (2013) Total daily energy expenditure is increased following a single bout of sprint interval training. Physiol Rep 1(5):e00131. doi:10.1002/phy2.131 PubMedCentralCrossRefPubMed Sevits KJ, Melanson EL, Swibas T, Binns SE, Klochak AL, Lonac MC, Peltonen GL, Scalzo RL, Schweder MM, Smith AM, Wood LM, Melby CL, Bell C (2013) Total daily energy expenditure is increased following a single bout of sprint interval training. Physiol Rep 1(5):e00131. doi:10.​1002/​phy2.​131 PubMedCentralCrossRefPubMed
Zurück zum Zitat Siegel S, Castellan NJ (1988) Nonparametric statistics for the behavioral sciences. McGraw-Hill, New York Siegel S, Castellan NJ (1988) Nonparametric statistics for the behavioral sciences. McGraw-Hill, New York
Zurück zum Zitat Skelly LE, Andrews PC, Gillen JB, Martin BJ, Percival ME, Gibala MJ (2014) High-intensity interval exercise induces 24-h energy expenditure similar to traditional endurance exercise despite reduced time commitment. Appl Physiol Nutr Metab 39(7):845–848. doi:10.1139/apnm-2013-0562 CrossRefPubMed Skelly LE, Andrews PC, Gillen JB, Martin BJ, Percival ME, Gibala MJ (2014) High-intensity interval exercise induces 24-h energy expenditure similar to traditional endurance exercise despite reduced time commitment. Appl Physiol Nutr Metab 39(7):845–848. doi:10.​1139/​apnm-2013-0562 CrossRefPubMed
Zurück zum Zitat Steinberg GR, Watt MJ, McGee SL, Chan S, Hargreaves M, Febbraio MA, Stapleton D, Kemp BE (2006) Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle. Appl Physiol Nutr Metab 31(3):302–312. doi:10.1139/h06-003 CrossRefPubMed Steinberg GR, Watt MJ, McGee SL, Chan S, Hargreaves M, Febbraio MA, Stapleton D, Kemp BE (2006) Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle. Appl Physiol Nutr Metab 31(3):302–312. doi:10.​1139/​h06-003 CrossRefPubMed
Zurück zum Zitat Trapp EG, Chisholm DJ, Freund J, Boutcher SH (2008) The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes 32(4):684–691. doi:10.1038/sj.ijo.0803781 CrossRef Trapp EG, Chisholm DJ, Freund J, Boutcher SH (2008) The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes 32(4):684–691. doi:10.​1038/​sj.​ijo.​0803781 CrossRef
Zurück zum Zitat Ueda SY, Yoshikawa T, Katsura Y, Usui T, Nakao H, Fujimoto S (2009) Changes in gut hormone levels and negative energy balance during aerobic exercise in obese young males. J Endocrinol 201(1):151–159. doi:10.1677/JOE-08-0500 CrossRefPubMed Ueda SY, Yoshikawa T, Katsura Y, Usui T, Nakao H, Fujimoto S (2009) Changes in gut hormone levels and negative energy balance during aerobic exercise in obese young males. J Endocrinol 201(1):151–159. doi:10.​1677/​JOE-08-0500 CrossRefPubMed
Zurück zum Zitat Vincent S, Berthon P, Zouhal H, Moussa E, Catheline M, Bentue-Ferrer D, Gratas-Delamarche A (2004) Plasma glucose, insulin and catecholamine responses to a Wingate test in physically active women and men. Eur J Appl Physiol 91(1):15–21. doi:10.1007/s00421-003-0957-5 CrossRefPubMed Vincent S, Berthon P, Zouhal H, Moussa E, Catheline M, Bentue-Ferrer D, Gratas-Delamarche A (2004) Plasma glucose, insulin and catecholamine responses to a Wingate test in physically active women and men. Eur J Appl Physiol 91(1):15–21. doi:10.​1007/​s00421-003-0957-5 CrossRefPubMed
Zurück zum Zitat Wasse LK, Sunderland C, King JA, Miyashita M, Stensel DJ (2013) The influence of vigorous running and cycling exercise on hunger perceptions and plasma acylated ghrelin concentrations in lean young men. Appl Physiol Nutr Metab 38(1):1–6. doi:10.1139/apnm-2012-0154 CrossRefPubMed Wasse LK, Sunderland C, King JA, Miyashita M, Stensel DJ (2013) The influence of vigorous running and cycling exercise on hunger perceptions and plasma acylated ghrelin concentrations in lean young men. Appl Physiol Nutr Metab 38(1):1–6. doi:10.​1139/​apnm-2012-0154 CrossRefPubMed
Zurück zum Zitat Williams CB, Zelt JGE, Castellani LN, Little JP, Jung ME, Wright DC, Tschakovsky ME, Gurd BJ (2013) Changes in mechanisms proposed to mediate fat loss following an acute bout of high-intensity interval and endurance exercise. Appl Physiol Nutr Metab. doi:10.1139/apnm-2013-0101 PubMedCentral Williams CB, Zelt JGE, Castellani LN, Little JP, Jung ME, Wright DC, Tschakovsky ME, Gurd BJ (2013) Changes in mechanisms proposed to mediate fat loss following an acute bout of high-intensity interval and endurance exercise. Appl Physiol Nutr Metab. doi:10.​1139/​apnm-2013-0101 PubMedCentral
Metadaten
Titel
Physiological and molecular responses to an acute bout of reduced-exertion high-intensity interval training (REHIT)
verfasst von
R. S. Metcalfe
F. Koumanov
J. S. Ruffino
K. A. Stokes
G. D. Holman
D. Thompson
N. B. J. Vollaard
Publikationsdatum
01.11.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Applied Physiology / Ausgabe 11/2015
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-015-3217-6

Weitere Artikel der Ausgabe 11/2015

European Journal of Applied Physiology 11/2015 Zur Ausgabe