Skip to main content
Erschienen in: Annals of Nuclear Medicine 8/2022

24.05.2022 | Original Article

Physiological background parenchymal uptake of 18F-FDG in normal breast tissues using dedicated breast PET: correlation with mammographic breast composition, menopausal status, and menstrual cycle

verfasst von: Yuri Shimizu, Hiroko Satake, Satoko Ishigaki, Kazuhiro Shimamoto, Fuga Uota, Masanori Tadokoro, Tomohiro Sato, Katsuhiko Kato, Tsuneo Ishiguchi, Shinji Naganawa

Erschienen in: Annals of Nuclear Medicine | Ausgabe 8/2022

Einloggen, um Zugang zu erhalten

Abstract

Objective

This study aimed to quantitatively evaluate the effects of age, mammographic density, menopausal status, and menstrual cycle on background parenchymal uptake (BPU) using ring-shaped dedicated breast positron emission tomography (dbPET).

Methods

This study included 186 adult women who underwent mammography and dbPET on the same day and had no abnormalities classified as Breast Imaging Reporting and Data System (BI-RADS) category 1 on both examinations. The volume of interest (VOI) was placed in the glandular tissue of both breasts, and the maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and metabolic breast volume (MBV) were measured as indicators of BPU. We analyzed the correlation between BPU and age, mammographic density, menopausal status, and menstrual cycle.

Results

The SUVmax and SUVmean for normal breast tissue were inversely correlated with age (both p < 0.001). The SUVmax, SUVmean, and MBV of mammographically dense breast tissues were significantly higher than those of non-dense breast tissues (all p < 0.001). The SUVmax, SUVmean, and MBV of normal breast tissue in premenopausal women were significantly higher than those in postmenopausal women (p < 0.001, p < 0.001, p = 0.002, respectively). In the study, 59 premenopausal women, the SUVmax of normal breast tissue in the menstrual-follicular phase was significantly lower than that in the periovulatory-luteal phase (p = 0.02). When we sorted the premenopausal women by mammographic breast composition, the SUVmax and SUVmean of normal breast tissues in the menstrual-follicular phase were significantly lower than those in the periovulatory-luteal phase in the 44 premenopausal women with dense breasts (p = 0.007, and p = 0.038, respectively), whereas no statistically significant difference was found between the menstrual-follicular phase and the periovulatory-luteal phase in the 15 premenopausal women with non-dense breasts.

Conclusions

BPU in normal breast tissues assessed using ring-shaped dbPET was associated with mammographic density, menopausal status, and women’s menstrual cycle. The menstrual cycle was significantly associated with BPU in premenopausal women with dense breasts but not in women with non-dense breasts.
Literatur
1.
Zurück zum Zitat García Hernández T, Vicedo González A, Ferrer Rebolleda J, Sánchez Jurado R, Roselló Ferrando J, Brualla González L, et al. Performance evaluation of a high resolution dedicated breast PET scanner. Med Phys. 2016;43:2261.CrossRef García Hernández T, Vicedo González A, Ferrer Rebolleda J, Sánchez Jurado R, Roselló Ferrando J, Brualla González L, et al. Performance evaluation of a high resolution dedicated breast PET scanner. Med Phys. 2016;43:2261.CrossRef
2.
Zurück zum Zitat Nishimatsu K, Nakamoto Y, Miyake KK, Ishimori T, Kanao S, Toi M, et al. Higher breast cancer conspicuity on dbPET compared to WB-PET/CT. Eur J Radiol. 2017;90:138–45.CrossRef Nishimatsu K, Nakamoto Y, Miyake KK, Ishimori T, Kanao S, Toi M, et al. Higher breast cancer conspicuity on dbPET compared to WB-PET/CT. Eur J Radiol. 2017;90:138–45.CrossRef
3.
Zurück zum Zitat Fowler AM. A molecular approach to breast imaging. J Nucl Med. 2014;55:177–80.CrossRef Fowler AM. A molecular approach to breast imaging. J Nucl Med. 2014;55:177–80.CrossRef
4.
Zurück zum Zitat Vranjesevic D, Schiepers C, Silverman DH, Quon A, Villalpando J, Dahlbom M, et al. Relationship between 18F-FDG uptake and breast density in women with normal breast tissue. J Nucl Med. 2003;44:1238–42.PubMed Vranjesevic D, Schiepers C, Silverman DH, Quon A, Villalpando J, Dahlbom M, et al. Relationship between 18F-FDG uptake and breast density in women with normal breast tissue. J Nucl Med. 2003;44:1238–42.PubMed
5.
Zurück zum Zitat Zytoon AA. Standardized uptake value variations of normal glandular breast tissue at dual time point FDG-PET/CT imaging. Int J Med Imaging. 2013;1:56–65.CrossRef Zytoon AA. Standardized uptake value variations of normal glandular breast tissue at dual time point FDG-PET/CT imaging. Int J Med Imaging. 2013;1:56–65.CrossRef
6.
Zurück zum Zitat Mavi A, Cermik TF, Urhan M, Puskulcu H, Basu S, Cucchiara AJ, et al. The effect of age, menopausal state, and breast density on 18F-FDG uptake in normal glandular breast tissue. J Nucl Med. 2010;51:347–52.CrossRef Mavi A, Cermik TF, Urhan M, Puskulcu H, Basu S, Cucchiara AJ, et al. The effect of age, menopausal state, and breast density on 18F-FDG uptake in normal glandular breast tissue. J Nucl Med. 2010;51:347–52.CrossRef
7.
Zurück zum Zitat Lin CY, Ding HJ, Liu CS, Chen YK, Lin CC, Kao CH. Correlation between the intensity of breast FDG uptake and menstrual cycle. Acad Radiol. 2007;14:940–4.CrossRef Lin CY, Ding HJ, Liu CS, Chen YK, Lin CC, Kao CH. Correlation between the intensity of breast FDG uptake and menstrual cycle. Acad Radiol. 2007;14:940–4.CrossRef
8.
Zurück zum Zitat An YS, Jung Y, Kim JY, Han S, Kang DK, Park SY, et al. Metabolic activity of normal glandular tissue on 18F-Fluorodeoxyglucose positron emission tomography/computed tomography: correlation with menstrual cycles and parenchymal enhancements. J Breast Cancer. 2017;20:386–92.CrossRef An YS, Jung Y, Kim JY, Han S, Kang DK, Park SY, et al. Metabolic activity of normal glandular tissue on 18F-Fluorodeoxyglucose positron emission tomography/computed tomography: correlation with menstrual cycles and parenchymal enhancements. J Breast Cancer. 2017;20:386–92.CrossRef
9.
Zurück zum Zitat Park H-H, Shin JY, Lee JY, Jin GH, Kim HS, Lyu KY, et al. Discussion on the alteration of 18F-FDG uptake by the breast according to the menstrual cycle in PET imaging. Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:2469–72.PubMed Park H-H, Shin JY, Lee JY, Jin GH, Kim HS, Lyu KY, et al. Discussion on the alteration of 18F-FDG uptake by the breast according to the menstrual cycle in PET imaging. Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:2469–72.PubMed
10.
Zurück zum Zitat Koo HR, Moon WK, Chun IK, Eo JS, Jeyanth JX, Chang JM, et al. Background 18F-FDG uptake in positron emission mammography (PEM): correlation with mammographic density and background parenchymal enhancement in breast MRI. Eur J Radiol. 2013;82:1738–42.CrossRef Koo HR, Moon WK, Chun IK, Eo JS, Jeyanth JX, Chang JM, et al. Background 18F-FDG uptake in positron emission mammography (PEM): correlation with mammographic density and background parenchymal enhancement in breast MRI. Eur J Radiol. 2013;82:1738–42.CrossRef
11.
Zurück zum Zitat Erdi YE, Mawlawi O, Larson SM, Imbriaco M, Yeung H, Finn R, et al. Segmentation of lung lesion volume by adaptive positron emission tomography image thresholding. Cancer. 1997;80(Suppl):2505–9.CrossRef Erdi YE, Mawlawi O, Larson SM, Imbriaco M, Yeung H, Finn R, et al. Segmentation of lung lesion volume by adaptive positron emission tomography image thresholding. Cancer. 1997;80(Suppl):2505–9.CrossRef
12.
Zurück zum Zitat Lakhani P, Maidment ADA, Weinstein SP, Kung JW, Alavi A. Correlation between quantified breast densities from digital mammography and 18F-FDG PET uptake. Breast J. 2009;15:339–47.CrossRef Lakhani P, Maidment ADA, Weinstein SP, Kung JW, Alavi A. Correlation between quantified breast densities from digital mammography and 18F-FDG PET uptake. Breast J. 2009;15:339–47.CrossRef
13.
Zurück zum Zitat Christov K, Chew KL, Ljung BM, Waldman FM, Duarte LA, Goodson WH 3rd, et al. Proliferation of normal breast epithelial cells as shown by in vivo labeling with bromodeoxyuridine. Am J Pathol. 1991;138:1371–7.PubMedPubMedCentral Christov K, Chew KL, Ljung BM, Waldman FM, Duarte LA, Goodson WH 3rd, et al. Proliferation of normal breast epithelial cells as shown by in vivo labeling with bromodeoxyuridine. Am J Pathol. 1991;138:1371–7.PubMedPubMedCentral
14.
Zurück zum Zitat Longacre TA, Bartow SA. A correlative morphologic study of human breast and endometrium in the menstrual cycle. Am J Surg Pathol. 1986;10:382–93.CrossRef Longacre TA, Bartow SA. A correlative morphologic study of human breast and endometrium in the menstrual cycle. Am J Surg Pathol. 1986;10:382–93.CrossRef
15.
Zurück zum Zitat Ramakrishnan R, Khan SA, Badve S. Morphological changes in breast tissue with menstrual cycle. Mod Pathol. 2002;15:1348–56.CrossRef Ramakrishnan R, Khan SA, Badve S. Morphological changes in breast tissue with menstrual cycle. Mod Pathol. 2002;15:1348–56.CrossRef
16.
Zurück zum Zitat Brisken C, Hess K, Jeitziner R. Progesterone and overlooked endocrine pathways in breast cancer pathogenesis. Endocrinology. 2015;156:3442–50.CrossRef Brisken C, Hess K, Jeitziner R. Progesterone and overlooked endocrine pathways in breast cancer pathogenesis. Endocrinology. 2015;156:3442–50.CrossRef
17.
Zurück zum Zitat Speroff L. Role of progesterone in normal breast physiology. J Reprod Med. 1999;44(Suppl):172–9.PubMed Speroff L. Role of progesterone in normal breast physiology. J Reprod Med. 1999;44(Suppl):172–9.PubMed
18.
Zurück zum Zitat Chang KJ, Lee TT, Linares-Cruz G, Fournier S, de Ligniéres B. Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo. Fertil Steril. 1995;63:785–91.CrossRef Chang KJ, Lee TT, Linares-Cruz G, Fournier S, de Ligniéres B. Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo. Fertil Steril. 1995;63:785–91.CrossRef
19.
Zurück zum Zitat Pike MC, Spicer DV, Dahmoush L, Press MF. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev. 1993;15:17–35.CrossRef Pike MC, Spicer DV, Dahmoush L, Press MF. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev. 1993;15:17–35.CrossRef
20.
Zurück zum Zitat Navarrete MAH, Maier CM, Falzoni R, de Quadros LGA, Lima GR, Baracat EC, et al. Assessment of the proliferative, apoptotic and cellular renovation indices of the human mammary epithelium during the follicular and luteal phases of the menstrual cycle. Breast Cancer Res. 2005;7:R306–13.CrossRef Navarrete MAH, Maier CM, Falzoni R, de Quadros LGA, Lima GR, Baracat EC, et al. Assessment of the proliferative, apoptotic and cellular renovation indices of the human mammary epithelium during the follicular and luteal phases of the menstrual cycle. Breast Cancer Res. 2005;7:R306–13.CrossRef
21.
Zurück zum Zitat Satoh Y, Kawamoto M, Kubota K, Murakami K, Hosono M, Senda M, et al. Clinical practice guidelines for high-resolution breast PET, 2019 edition. Ann Nucl Med. 2021;35:406–14.CrossRef Satoh Y, Kawamoto M, Kubota K, Murakami K, Hosono M, Senda M, et al. Clinical practice guidelines for high-resolution breast PET, 2019 edition. Ann Nucl Med. 2021;35:406–14.CrossRef
22.
Zurück zum Zitat Satoh Y, Motosugi U, Imai M, Omiya Y, Onishi H. Evaluation of image quality at the detector’s edge of dedicated breast positron emission tomography. EJNMMI Phys. 2021;8:5.CrossRef Satoh Y, Motosugi U, Imai M, Omiya Y, Onishi H. Evaluation of image quality at the detector’s edge of dedicated breast positron emission tomography. EJNMMI Phys. 2021;8:5.CrossRef
23.
Zurück zum Zitat Satoh Y, Motosugi U, Imai M, Onishi H. Comparison of dedicated breast positron emission tomography and whole-body positron emission tomography/computed tomography images: a common phantom study. Ann Nucl Med. 2020;34:119–27.CrossRef Satoh Y, Motosugi U, Imai M, Onishi H. Comparison of dedicated breast positron emission tomography and whole-body positron emission tomography/computed tomography images: a common phantom study. Ann Nucl Med. 2020;34:119–27.CrossRef
24.
Zurück zum Zitat Sueoka S, Sasada S, Masumoto N, Emi A, Kadoya T, Okada M. Performance of dedicated breast positron emission tomography in the detection of small and low-grade breast cancer. Breast Cancer Res Treat. 2021;187(1):125–33.CrossRef Sueoka S, Sasada S, Masumoto N, Emi A, Kadoya T, Okada M. Performance of dedicated breast positron emission tomography in the detection of small and low-grade breast cancer. Breast Cancer Res Treat. 2021;187(1):125–33.CrossRef
Metadaten
Titel
Physiological background parenchymal uptake of 18F-FDG in normal breast tissues using dedicated breast PET: correlation with mammographic breast composition, menopausal status, and menstrual cycle
verfasst von
Yuri Shimizu
Hiroko Satake
Satoko Ishigaki
Kazuhiro Shimamoto
Fuga Uota
Masanori Tadokoro
Tomohiro Sato
Katsuhiko Kato
Tsuneo Ishiguchi
Shinji Naganawa
Publikationsdatum
24.05.2022
Verlag
Springer Nature Singapore
Erschienen in
Annals of Nuclear Medicine / Ausgabe 8/2022
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-022-01754-4

Weitere Artikel der Ausgabe 8/2022

Annals of Nuclear Medicine 8/2022 Zur Ausgabe