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Inflammopharmacology
Erschienen in:

03.02.2024 | Original Article

Phytochemical profiling, antioxidant, cytotoxic, and anti-inflammatory activities of Plectranthus rugosus extract and fractions: in vitro, in vivo, and in silico approaches

verfasst von: Reyaz Hassan Mir, Roohi Mohi-ud-din, Lamya Ahmed Al-Keridis, Bilal Ahmad, Nawaf Alshammari, Mitesh Patel, Mohd Adnan, Mubashir Hussain Masoodi

Erschienen in: Inflammopharmacology | Ausgabe 2/2024

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Abstract

Background

Inflammation is a key biological reaction that comprises a complex network of signals that both initiate and stop the inflammation process.

Purpose

This study targets to evaluate the anti-inflammatory potential of the leaves of the Plectranthus rugosus (P. rugosus) plant involving both in vitro and in vivo measures. The current available drugs exhibit serious side effects. Traditional medicines impart an essential role in drug development. P. rugosus is a plant used in traditional medicine of Tropical Africa, China, and Australia to treat various diseases.

Methods

Lipopolysaccharide (LPS), an endotoxin, kindles macrophages to discharge huge quantities of pro-inflammatory cytokines like TNF-α and IL-6. So, clampdown of macrophage stimulation may have a beneficial potential to treat various inflammatory disorders. The leaves of the P. rugosus are used for swelling purpose by local population; however, its use as an anti-inflammatory agent and associated disorders has no scientific evidence.

Results

The extracts of the plant Plectranthus rugosus ethanolic extract (PREE), Plectranthus rugosus ethyl acetate extract (PREAF), and the compound isolated (oleanolic acid) suppress the pro-inflammatory cytokines (IL-6 and TNF-α) and nitric oxide (NO), confirming its importance in traditional medicine.

Conclusion

The pro-inflammatory cytokines are inhibited by P. rugosus extracts, as well as an isolated compound oleanolic acid without compromising cell viability.
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Metadaten
Titel
Phytochemical profiling, antioxidant, cytotoxic, and anti-inflammatory activities of Plectranthus rugosus extract and fractions: in vitro, in vivo, and in silico approaches
verfasst von
Reyaz Hassan Mir
Roohi Mohi-ud-din
Lamya Ahmed Al-Keridis
Bilal Ahmad
Nawaf Alshammari
Mitesh Patel
Mohd Adnan
Mubashir Hussain Masoodi
Publikationsdatum
03.02.2024
Verlag
Springer International Publishing
Erschienen in
Inflammopharmacology / Ausgabe 2/2024
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-023-01419-2

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