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12.09.2018 | Review | Ausgabe 6/2018

Picket-fences in the plasma membrane: functions in immune cells and phagocytosis

Zeitschrift:: Seminars in Immunopathology > Ausgabe 6/2018

Autoren:: Sivakami M. Mylvaganam, Sergio Grinstein, Spencer A. Freeman

Wichtige Hinweise

This article is a contribution to the special issue on Professional and Nonprofessional Phagocytes and Diseases - Guest Editor: Toru Miyazaki

Abstract

Recent studies of molecular mobility in the plasma membrane have revealed that diffusion is restricted by cytoskeletal networks or fences. Transmembrane protein “pickets” that reversibly associate with the membrane-associated skeleton and with the pericellular coat impede the movement of unattached bystander molecules. While membrane picket-fences were originally described as barriers to free diffusion in more passive cell types such as fibroblasts, they have particularly important functions in the more dynamic immune cells. In phagocytes, such fences curtail spontaneous activation and their disassembly facilitates stimulation by target particles, fostering receptor clustering and the exclusion of phosphatases from the phagocytic cup. In this review, we describe the nature of the cellular cytoskeleton and of the exoskeleton created by the pericellular coat, their association with transmembrane pickets, and the modulation of molecular mobility during phagocytosis.

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Titel: Picket-fences in the plasma membrane: functions in immune cells and phagocytosis
Autoren:: Sivakami M. Mylvaganam
Sergio Grinstein
Spencer A. Freeman
Publikationsdatum: 12.09.2018
DOI: https://doi.org/10.1007/s00281-018-0705-x
Verlag: Springer Berlin Heidelberg
Zeitschrift: Seminars in Immunopathology
Ausgabe 6/2018
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300

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15.11.2018 | DGN-Kongress 2018 | Nachrichten

Picket-fences in the plasma membrane: functions in immune cells and phagocytosis

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