Pilomyxoid astrocytomas: a short review

Zurück zum Zitat Tihan T, Fisher PG, Kepner JL, Godfraind C, McComb RD, Goldthwaite PT, Burger PC (1999) Pediatric astrocytomas with monomorphous pilomyxoid features and a less favorable outcome. J Neuropathol Exp Neurol 58:1061–1068CrossRefPubMed Tihan T, Fisher PG, Kepner JL, Godfraind C, McComb RD, Goldthwaite PT, Burger PC (1999) Pediatric astrocytomas with monomorphous pilomyxoid features and a less favorable outcome. J Neuropathol Exp Neurol 58:1061–1068CrossRefPubMed

Zurück zum Zitat Louis D, Ohgaki H, Wiestler O, Cavenee W, Ellison D, Figarella-Branger D et al (2016) WHO classification of tumours of the central nervous system, Revised, 4th edn. IARC, Lyon (ISBN 978-92-832-4492-9 Google Scholar) Louis D, Ohgaki H, Wiestler O, Cavenee W, Ellison D, Figarella-Branger D et al (2016) WHO classification of tumours of the central nervous system, Revised, 4th edn. IARC, Lyon (ISBN 978-92-832-4492-9 Google Scholar)

Zurück zum Zitat Brat DJ, Scheithauer BW, Fuller GN, Tihan T (2007) Newly codified glial neoplasms of the 2007 WHO classification of tumours of the central nervous system: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. Brain Pathol 17:319–324CrossRefPubMed Brat DJ, Scheithauer BW, Fuller GN, Tihan T (2007) Newly codified glial neoplasms of the 2007 WHO classification of tumours of the central nervous system: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. Brain Pathol 17:319–324CrossRefPubMed

Zurück zum Zitat Komotar RJ, Burger PC, Carson BS, Brem H, Olivi A, Goldthwaite PT, Tihan T (2004) Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomas. Neurosurgery 54:72–79 (discussion 9–80) CrossRefPubMed Komotar RJ, Burger PC, Carson BS, Brem H, Olivi A, Goldthwaite PT, Tihan T (2004) Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomas. Neurosurgery 54:72–79 (discussion 9–80) CrossRefPubMed

Zurück zum Zitat Chikai K, Ohnishi A, Kato T, Ikeda J, Sawamura Y, Iwasaki Y, Itoh T, Sawa H, Nagashima K (2004) Clinico-pathological features of pilomyxoid astrocytoma of the optic pathway. Acta Neuropathol 108:109–114CrossRefPubMed Chikai K, Ohnishi A, Kato T, Ikeda J, Sawamura Y, Iwasaki Y, Itoh T, Sawa H, Nagashima K (2004) Clinico-pathological features of pilomyxoid astrocytoma of the optic pathway. Acta Neuropathol 108:109–114CrossRefPubMed

Zurück zum Zitat Komotar RJ, Carson BS, Rao C, Chaffee S, Goldthwaite PT, Tihan T (2005) Pilomyxoid astrocytoma of the spinal cord: report of three cases. Neurosurgery 56:191CrossRefPubMed Komotar RJ, Carson BS, Rao C, Chaffee S, Goldthwaite PT, Tihan T (2005) Pilomyxoid astrocytoma of the spinal cord: report of three cases. Neurosurgery 56:191CrossRefPubMed

Zurück zum Zitat Sajadi A, Janzer RC, Lu TLC, Duff JM (2008) Pilomyxoid astrocytoma of the spinal cord in an adult. Acta Neurochir 150:729–731CrossRefPubMed Sajadi A, Janzer RC, Lu TLC, Duff JM (2008) Pilomyxoid astrocytoma of the spinal cord in an adult. Acta Neurochir 150:729–731CrossRefPubMed

Zurück zum Zitat Abe K, Sakaguchi M, Fujii M, Takahashi M, Shizukuishi T, Aizawa T, Kano T, Kawamata T, Shichino H, Honma T (2009) Pilomyxoid astrocytoma difficult to differentiate from pilocytic astrocytoma even with typical MRI findings: case report. Neurosurg Q 19:295CrossRef Abe K, Sakaguchi M, Fujii M, Takahashi M, Shizukuishi T, Aizawa T, Kano T, Kawamata T, Shichino H, Honma T (2009) Pilomyxoid astrocytoma difficult to differentiate from pilocytic astrocytoma even with typical MRI findings: case report. Neurosurg Q 19:295CrossRef

Zurück zum Zitat Arslanoglu A, Cirak B, Horska A, Okoh J, Tihan T, Aronson L, Avellino AM, Burger PC (2003) Yousem DMJAjon: MR imaging characteristics of pilomyxoid astrocytomas. Am J Neuroradiol 24:1906–1908PubMed Arslanoglu A, Cirak B, Horska A, Okoh J, Tihan T, Aronson L, Avellino AM, Burger PC (2003) Yousem DMJAjon: MR imaging characteristics of pilomyxoid astrocytomas. Am J Neuroradiol 24:1906–1908PubMed

Zurück zum Zitat Alkonyi B, Nowak J, Gnekow AK, Pietsch T, Warmuth-Metz M (2015) Differential imaging characteristics and dissemination potential of pilomyxoid astrocytomas versus pilocytic astrocytomas. Neuroradiology 57:625–638CrossRefPubMed Alkonyi B, Nowak J, Gnekow AK, Pietsch T, Warmuth-Metz M (2015) Differential imaging characteristics and dissemination potential of pilomyxoid astrocytomas versus pilocytic astrocytomas. Neuroradiology 57:625–638CrossRefPubMed

Zurück zum Zitat Johnson MW, Eberhart CG, Perry A, Tihan T, Cohen KJ, Rosenblum MK, Rais-Bahrami S, Goldthwaite P, Burger PC (2010) Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol 34:1783–1791CrossRefPubMed Johnson MW, Eberhart CG, Perry A, Tihan T, Cohen KJ, Rosenblum MK, Rais-Bahrami S, Goldthwaite P, Burger PC (2010) Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol 34:1783–1791CrossRefPubMed

Zurück zum Zitat Fernandez C, Figarella-Branger D, Girard N, Bouvier-Labit C, Gouvernet J, Paredes AP, Lena GJN (2003) Pilocytic astrocytomas in children: prognostic factors—a retrospective study of 80 cases. Neurosurgery 53:544–555CrossRefPubMed Fernandez C, Figarella-Branger D, Girard N, Bouvier-Labit C, Gouvernet J, Paredes AP, Lena GJN (2003) Pilocytic astrocytomas in children: prognostic factors—a retrospective study of 80 cases. Neurosurgery 53:544–555CrossRefPubMed

Zurück zum Zitat Colin C, Padovani L, Chappe C, Mercurio S, Scavarda D, Loundou A, Frassineti F, Andre N, Bouvier C, Korshunov A, Lena G, Figarella-Branger D (2013) Outcome analysis of childhood pilocytic astrocytomas: a retrospective study of 148 cases at a single institution. Neuropathol Appl Neurobiol 39:693–705CrossRefPubMed Colin C, Padovani L, Chappe C, Mercurio S, Scavarda D, Loundou A, Frassineti F, Andre N, Bouvier C, Korshunov A, Lena G, Figarella-Branger D (2013) Outcome analysis of childhood pilocytic astrocytomas: a retrospective study of 148 cases at a single institution. Neuropathol Appl Neurobiol 39:693–705CrossRefPubMed

Zurück zum Zitat Fuller CE (2016) Pilocytic astrocytoma and pilomyxoid astrocytoma. In: Adesina AM, Tihan T, Fuller CE, Poussant TY (eds) Atlas of pediatric brain tumors, 2nd edn. Springer, Switzerland, pp 7–17CrossRef Fuller CE (2016) Pilocytic astrocytoma and pilomyxoid astrocytoma. In: Adesina AM, Tihan T, Fuller CE, Poussant TY (eds) Atlas of pediatric brain tumors, 2nd edn. Springer, Switzerland, pp 7–17CrossRef

Zurück zum Zitat Yde CW, Sehested A, Mateu-Regué À, Østrup O, Scheie D, Nysom K, Nielsen FC, Rossing MJCG (2016) A new NFIA: RAF1 fusion activating the MAPK pathway in pilocytic astrocytoma. Cancer Genetics 209:440–444CrossRefPubMed Yde CW, Sehested A, Mateu-Regué À, Østrup O, Scheie D, Nysom K, Nielsen FC, Rossing MJCG (2016) A new NFIA: RAF1 fusion activating the MAPK pathway in pilocytic astrocytoma. Cancer Genetics 209:440–444CrossRefPubMed

Zurück zum Zitat Jones DTW, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz H-J, Zichner T, Lambert SR, Ryzhova M, Quang DAK, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Şeker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho Y-J, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo M-L, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, The International Cancer Genome Consortium PedBrain Tumor P, Pfister SM (2013) Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet 45:927CrossRefPubMedPubMedCentral Jones DTW, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz H-J, Zichner T, Lambert SR, Ryzhova M, Quang DAK, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Şeker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho Y-J, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo M-L, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, The International Cancer Genome Consortium PedBrain Tumor P, Pfister SM (2013) Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet 45:927CrossRefPubMedPubMedCentral

Zurück zum Zitat Jeon Y-K, Cheon J-E, Kim S-K, Wang K-C, Cho B-K, Park S-H (2008) Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization. Mod Pathol 21:1345CrossRefPubMed Jeon Y-K, Cheon J-E, Kim S-K, Wang K-C, Cho B-K, Park S-H (2008) Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization. Mod Pathol 21:1345CrossRefPubMed

Zurück zum Zitat Kleinschmidt-DeMasters BK, Donson AM, Vogel H, Foreman NK (2015) Pilomyxoid astrocytoma (PMA) shows significant differences in gene expression vs. pilocytic astrocytoma (PA) and variable tendency toward maturation to PA. Brain Pathol 25:429–440CrossRefPubMedPubMedCentral Kleinschmidt-DeMasters BK, Donson AM, Vogel H, Foreman NK (2015) Pilomyxoid astrocytoma (PMA) shows significant differences in gene expression vs. pilocytic astrocytoma (PA) and variable tendency toward maturation to PA. Brain Pathol 25:429–440CrossRefPubMedPubMedCentral

Zurück zum Zitat Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein SJN-O (2016) Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro-oncology 19:699–709PubMedCentral Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein SJN-O (2016) Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro-oncology 19:699–709PubMedCentral