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The Official Journal of the Pituitary Society

Pituitary OnlineFirst articles


Clinical, pathologic, and imaging characteristics of pituitary null cell adenomas as defined according to the 2017 World Health Organization criteria: a case series from two pituitary centers

Null cell pituitary adenomas (NCAs) are clinically nonfunctioning pituitary lesions that either present with symptoms of mass effect, such as hypopituitarism or chiasmopathy, or are discovered incidentally [ 1 ]. The term NCA was first introduced …


Peel-off resection of the pituitary gland for functional pituitary adenomas: pathological significance and impact on pituitary function

Transsphenoidal surgery (TSS) has become the first-line treatment for almost all functional pituitary adenomas (FPAs), except for prolactinomas. Studies have reported that many FPAs are effectively resected by TSS with minimal postoperative …


Static and dynamic balances of patients with acromegaly and impact of exercise on balance

Acromegaly is a chronic debilitating disease resulting from growth hormone (GH) hypersecretion, usually from a pituitary adenoma. Besides the mechanical effects of the pituitary tumor as headache and visual disturbances, patients with acromegaly …

23.07.2019 Open Access

Staging and managing patients with acromegaly in clinical practice: baseline data from the SAGIT® validation study

Acromegaly is a multi-system disease characterized by overproduction of growth hormone (GH) and an accompanying increase in insulin-like growth factor-1 (IGF-1) levels, usually due to a GH-secreting pituitary tumor (predominantly macroadenomas).


Ipilimumab-induced hypophysitis, a single academic center experience

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an inhibitory molecule on T-cells which promotes downregulation of T cell activation and it’s blockage potentiates antitumor T cell immune response [ 1 ]. Ipilimumab is a fully human cytotoxic CTLA-4 …

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