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06.06.2017 | Maternal-Fetal Medicine

Placental and cord blood brain derived neurotrophic factor levels are decreased in nondiabetic macrosomia

verfasst von: Qian-Ying Cai, Heng-Xin Zhang, Chen-Chen Wang, Hao Sun, Shu-Qiang Sun, Yu-Huan Wang, Hong-Tao Yan, Xin-Jun Yang

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 2/2017

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Abstract

Purpose

To measure levels of placental brain derived neurotrophic factor (BDNF) gene expression and umbilical cord blood BDNF in neonates with nondiabetic macrosomia and determine associations between these levels and macrosomia.

Methods

This case–control study included 58 nondiabetic macrosomic and 59 normal birth weight mother-infant pairs. Data were collected from interviews and our hospital’s database. BDNF gene expression was quantified in placental tissues using quantitative real-time polymerase chain reaction (n = 117). Umbilical cord blood BDNF levels were measured by enzyme-linked immunosorbent assay (n = 90). Multivariate logistic regression models were used to evaluate associations between BDNF levels and macrosomia.

Results

Placental BDNF gene expression (P = 0.026) and cord blood BDNF (P = 0.008) were lower in neonates with nondiabetic macrosomia than in normal birth weight controls. Cord blood BDNF was significantly lower in vaginally delivered macrosomic neonates than vaginally delivered controls (P = 0.014), but cord BDNF did not differ between vaginal and cesarean section delivery modes in macrosomic neonates. Cord blood BDNF was positively associated with gestational age in control neonates (r = 0.496, P < 0.001), but not in macrosomic neonates. Cord blood BDNF was positively associated with placental BDNF relative expression (r _s = 0.245, P = 0.02) in the total group. Higher cord blood BDNF levels were independently associated with protection against nondiabetic macrosomia (adjusted odds ratio 0.992; 95% confidence interval 0.986–0.998).

Conclusions

Both placental BDNF gene expression and cord blood BDNF were downregulated in neonates with nondiabetic macrosomia compared with normal birth weight neonates. Cord BDNF may partly derive from BDNF secreted by the placenta. Higher cord plasma BDNF levels protected against nondiabetic macrosomia.

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Titel: Placental and cord blood brain derived neurotrophic factor levels are decreased in nondiabetic macrosomia
verfasst von: Qian-Ying Cai
Heng-Xin Zhang
Chen-Chen Wang
Hao Sun
Shu-Qiang Sun
Yu-Huan Wang
Hong-Tao Yan
Xin-Jun Yang
Publikationsdatum: 06.06.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 2/2017
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4414-9

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Placental and cord blood brain derived neurotrophic factor levels are decreased in nondiabetic macrosomia

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Results

Conclusions

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