Erschienen in:
06.07.2016 | Case Report
PLAG1 expression is maintained in recurrent pleomorphic adenoma
verfasst von:
Beatriz Samara de Brito, Natália Giovanelli Gaspar, Erika Said Abu Egal, Celeste Sanchez-Romero, Antonio Santos Martins, Álfio José Tincani, Rogério de Oliveira Gondak, Oslei Paes de Almeida, Luiz Paulo Kowalski, Albina Altemani, Fernanda Viviane Mariano
Erschienen in:
Virchows Archiv
|
Ausgabe 4/2016
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Abstract
The proto-oncogene (pleomorphic adenoma gene 1 (PLAG1)) is immunohistochemically overexpressed in pleomorphic adenoma (PA). Its expression in recurrent pleomorphic adenoma (RPA), however, has not been investigated. Since complex mechanisms are involved in tumor recurrence, the aim of this study was to investigate whether PLAG1 overexpression occurs in RPA. We studied PLAG1 protein expression in 40 PAs and 36 RPAs by immunohistochemistry. Cases with immunopositive cells were classified into two categories, between 10 and 50 % and >50 %. In both groups, PLAG1 expression was observed in both epithelial and myoepithelial cells. Of PAs, 37 cases (93 %) were positive, while this was the case in 34 RPA cases (94 %). Our findings suggest that in addition to morphological similarity, PA and RPA express PLAG1, which might play a role in tumor recurrence. Furthermore, as for PA, expression of PLAG1 can be considered a valuable diagnostic marker for RPA.