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Angiogenesis
Erschienen in: Angiogenesis 3/2016

06.05.2016 | Review Paper

Plants and their active compounds: natural molecules to target angiogenesis

verfasst von: Kai Lu, Madhavi Bhat, Sujit Basu

Erschienen in: Angiogenesis | Ausgabe 3/2016

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Abstract

Angiogenesis, or new blood vessel formation, is an important process in the pathogenesis of several diseases and thus has been targeted for the prevention and treatment for many disorders. However, the anti-angiogenic agents that are currently in use are mainly synthetic compounds and humanized monoclonal antibodies, which are either expensive or toxic, thereby limiting their use in many patients. Therefore, it is necessary to identify less toxic, inexpensive, novel and effective anti-angiogenic molecules. Several studies have indicated that natural plant products can meet these criteria. In this review, we discuss the anti-angiogenic properties of natural compounds isolated from plants and the molecular mechanisms by which these molecules act. Finally, we summarize the advantages of using plant products as anti-angiogenic agents. Compared with currently available anti-angiogenic drugs, plant products may not only have similar therapeutic potential but are also inexpensive, less toxic, and easy to administer. However, novel and effective strategies are necessary to improve their bioavailability for clinical use.
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Metadaten
Titel
Plants and their active compounds: natural molecules to target angiogenesis
verfasst von
Kai Lu
Madhavi Bhat
Sujit Basu
Publikationsdatum
06.05.2016
Verlag
Springer Netherlands
Erschienen in
Angiogenesis / Ausgabe 3/2016
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-016-9512-y

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