Plasma angiotensin peptides as biomarkers of rheumatoid arthritis are correlated with anti-ACE2 auto-antibodies level and disease intensity
- 26.05.2022
- Original Article
Erschienen in:
- Verfasst von
- Sana Khajeh Pour
- Craig Scoville
- Susan S. Tavernier
- Ali Aghazadeh-Habashi
- Erschienen in
- Inflammopharmacology | Ausgabe 4/2022
Abstract
Background
This study aimed to explore a correlation between plasma angiotensin II/(1–7) (Ang II/Ang-(1–7)) ratio, anti-ACE2 autoantibodies level and disease activity in rheumatoid arthritis (RA) patients.
Methods
In a pilot study, the plasma level of Ang II, Ang-(1–7), and anti-ACE2 autoantibodies of twelve RA patients (five in active stage and seven in remission) were measured using an LC–MS/MS method and an ELISA kit, respectively.
Results
The Ang-(1–7) level was significantly higher in the remission group than in the active RA patients (7.63 ± 2.61 vs. 1.29 ± 0.81 ng/mL). On the contrary, the Ang II level was higher in those with active RA compared to the remission group (5.43 ± 1.82 vs. 0.87 ± 0.16 ng/mL). The mean ELISA score of anti-ACE2 autoantibodies in patients with active RA was significantly higher than patients in remission (1.41 ± 0.11 vs. 1.81 ± 0.11, p < 0.05).
Conclusion
This study result suggests that the angiotensin peptides concentration and anti-ACE2 autoantibodies levels can be used as biomarkers of RA. This will help clinicians evaluate better treatment success rates and disease prognosis to prevent long-term complications of RA.
Anzeige
- Titel
- Plasma angiotensin peptides as biomarkers of rheumatoid arthritis are correlated with anti-ACE2 auto-antibodies level and disease intensity
- Verfasst von
-
Sana Khajeh Pour
Craig Scoville
Susan S. Tavernier
Ali Aghazadeh-Habashi
- Publikationsdatum
- 26.05.2022
- Verlag
- Springer International Publishing
- Erschienen in
-
Inflammopharmacology / Ausgabe 4/2022
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608 - DOI
- https://doi.org/10.1007/s10787-022-01008-9
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.