Skip to main content
main-content

04.07.2016 | Retinal Disorders | Ausgabe 1/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 1/2017

Plasma E-selectin levels can play a role in the development of diabetic retinopathy

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 1/2017
Autoren:
Márta Kasza, J. Meleg, J. Vardai, B. Nagy Jr., E. Szalai, J. Damjanovich, A. Csutak, B. Ujhelyi, V. Nagy

Abstract

Purpose

Diabetic retinopathy is one of the leading causes of blindness. There are several risk factors, such as the duration of diabetes or glycemic control of the patient; however, several biochemical factors also alter the process. Our aim was to investigate the role of soluble E-selectin in the formation of diabetic retinopathy.

Patients and methods

Fifty-seven patients (37 female and 20 male, aged 61.71 ± 12.31 years) and 14 healthy control subjects (ten female and four male, aged 63.06 ± 10.46 years) were enrolled in the study. We measured the soluble E-selectin level in the plasma of patients by ELISA. All patients underwent careful ophthalmological examination, including ophthalmoscopy and color fundus photography, while diabetic retinopathy grading was performed in line with the 2012 classification of the American Academy of Ophthalmology (AAO).

Results

The soluble E-selectin level was significantly higher in patients with diabetes compared to controls (32.95 ng/ml vs. 26.55 ng/ml, p = 0.03). Dividing patients into groups by the presence of retinopathy, the E-selectin level was also significantly higher in the retinopathy group (p < 0.05). When we examined diabetic patients by the severity of retinopathy (groups A, B, and C, by the guidelines of the AAO), however, we did not find any significant difference in soluble E-selectin levels, although it tended to be higher in group B.

Conclusions

An elevated E-selectin level can play a role in the development of diabetic retinopathy, but it does not seem to alter disease severity. However, glycemic control and the reduction of cardiovascular risk factors may also alter the level of E-selectin that might play a role in the prevention of diabetic retinopathy.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Nicht verpassen: e.Med bis 22. Oktober 100 € günstiger.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 1/2017Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

06.07.2018 | Leitlinien, Stellungnahmen und Empfehlungen | Ausgabe 8/2018

Empfehlungen der DOG für die Planung klinischer Studien im Auftrage Dritter

März 2018

29.06.2018 | Das therapeutische und diagnostische Prinzip | Ausgabe 8/2018

Neuer Glaskörperersatz mit Hydrogel?

15.06.2018 | Video plus | Ausgabe 7/2018

Diakaustische Kammerwinkeluntersuchung

Videobeitrag