Introduction
Materials and methods
Study participants
Anthropometric and biochemical measures
Cell culture and gene expression analysis
HUVEC ELISA for soluble E-selectin
Statistical analysis
Results
Body anthropometry and biochemical analyses of T2DM patients
Anthropometric and biochemical analysis | Type 2 diabetes cohort |
---|---|
Cohort size | 79 |
Men | 42 |
Women | 37 |
Age (years) | 56 ± 12 |
Height (cm) | 165 ± 10 |
Weight (kg) | 87 ± 20.5 |
Body mass index (kg/m2) | 31.5 ± 5.4 |
Total fat (%) | 34.9 ± 9.3 |
Total muscle (kg) | 53 ± 11.8 |
Abdominal (trunk) fat (%) | 34.1 ± 9.4 |
Abdominal (trunk) muscle (kg) | 29 ± 5.7 |
Visceral fat score (0–60) | 13.2 ± 5.5 |
Fasting blood glucose (mmol/l) | 9.9 ± 3.8 |
HbA1c (mmol/mol) | 70.5 ± 17.6 |
Fasting insulin (mU/l) | 29.1 ± 42.6 |
HOMA β (%) | 67.2 ± 67.9 |
HOMA-S | 74 ± 71 |
Telomere length (T/S ratio) | 1.6 ± 0.2 |
Irisin (ng/ml) | 175.4 ± 131 |
Leptin (pg/ml) | 1529 ± 1372 |
Thrombomodulin (ng/ml) | 6.6 ± 6.3 |
E-selectin (ng/ml) | 50.9 ± 21.4 |
C-reactive protein (µg/ml) | 4.5 ± 3.99 |
Associations of plasma irisin with biochemical and anthropometric factors in type 2 diabetes
Measurement | β value | p value |
---|---|---|
Age | − 0.364
|
0.001
|
Height | − 0.171 | 0.13 |
Weight | 0.089 | 0.43 |
Body mass index (kg/m2) |
0.223
|
0.04
|
Total fat (%) |
0.241
|
0.03
|
Total muscle (kg) | − 0.134 | 0.23 |
Abdominal (trunk) fat (%) | 0.062 | 0.59 |
Abdominal (trunk) muscle (kg) | − 0.173 | 0.13 |
Visceral fat score | − 0.3
|
0.006
|
Fasting blood glucose (mmol/l) | − 0.03 | 0.79 |
HbA1c (mmol/mol) |
0.28
|
0.03
|
Fasting insulin (mU/l) | 0.08 | 0.46 |
HOMA β (%) | 0.01 | 0.92 |
HOMA-S | 0.05 | 0.65 |
Leptin (pg/ml) | − 0.24
|
0.02
|
Thrombomodulin (ng/ml) | − 0.16 | 0.15 |
E-selectin (ng/ml) |
0.43
| < 0.0001
|
C-reactive protein (µg/ml) | 0.05 | 0.62 |
T/S ratio | − 0.11 | 0.3 |