Background
Methods
Patients
Definitions of obesity and calculation of IR
Oral glucose tolerance test (OGTT)
Glucose stimulation of mouse islet cells
Statistical analysis
Results
General information
Age | FSH (U/L) | LH (U/L) | E2 (pmol/L) | PRL (nmol/L) | T (nmol/L) | |
---|---|---|---|---|---|---|
PCOS | 29.0 ± 3.0 | 4.45 ± 0.2 | 5.73 ± 0.4 | 129 ± 9.5 | 808 ± 62 | 1.71 ± 0.1 |
Control | 30.8 ± 4.4 | 5.24 ± 0.2 | 3.62 ± 0.1 | 112 ± 5.5 | 670 ± 27 | 0.98 ± 0.04 |
t values | 1.346 | 0.156 | 2.901 | 0.901 | 1.758 | 3.480 |
P values | 0.197 | 0.877 | 0.006a | 0.377 | 0.085 | 0.002a |
Obesity (%) | BMI | FPG (mmoL/L) | FINS (mU/L) | HOMA-IR | PRX3 (ng/ml) | |
---|---|---|---|---|---|---|
PCOS | 52.0 | 28.9 ± 4.4 | 6.1 ± 1.2 | 18.7 ± 1.3 | 4.7 ± 0.2 | 29.5 ± 3.8 |
Control | 10.7 | 23.2 ± 3.3 | 5.6 ± 0.5 | 11.2 ± 0.6 | 2.7 ± 0.1 | 29.3 ± 3.4 |
t (χ2) values | 10.68 | 5.334 | 1.559 | 2.833 | 2.575 | 0.107 |
P values | 0.001a | < 0.001a | 0.119 | 0.005a | 0.010a | 0.915 |
n | Age | BMI | FPG (mmoL/L) | FINS (mU/L) | HOMA-IR | PRX3 (ng/ml) | |
---|---|---|---|---|---|---|---|
Control-IRL -Lean | 28 | 29.6 ± 4.4 | 20.9 ± 3.3 | 5.3 ± 0.5 | 7.7 ± 0.6 | 1.8 ± 0.1 | 29.8 ± 3.4 |
t values | 0.397 | 7.534 | 2.580 | 7.961 | 4.962 | 0.156 | |
P values | 0.695 | < 0.001a | 0.02a | < 0.001a | < 0.001a | 0.877 | |
PCOS-IRH -Obese | 22 | 29.3 ± 3.0 | 31.4 ± 3.1 | 6.7 ± 1.5 | 29.3 ± 10.5 | 9.2 ± 5.2 | 30.4 ± 3.6 |
t values | −1.093 | 4.315 | 2.661 | 6.001 | 4.646 | 1.154 | |
P values | 0.293 | 0.001a | 0.02a | < 0.001a | 0.001a | 0.268 | |
PCOS-IRL -Lean | 10 | 31 ± 2.6 | 24.8 ± 2.0 | 5.3 ± 0.4 | 9.0 ± 2.6 | 1.9 ± 0.5 | 25.1 ± 2.7 |
Changes of plasma glucose, insulin, and PRX3 in OGTT
The association of plasma PRX3 with plasma glucose and insulin
BMI | FPG | FINS | HOMA-IR | |||||
---|---|---|---|---|---|---|---|---|
r values | P values | r values | P values | r values | P values | r values | P values | |
PCOS | 0.383 | 0.058 | 0.075 | 0.720 | 0.352 | 0.084 | 0.170 | 0.415 |
Control | −0.268 | 0.169 | −0.056 | 0.778 | 0.207 | 0.292 | −0.094 | 0.634 |